Glass and bioglass nanopowders by flame synthesis

Brunner, Tobias J.; Grass, Robert N.; Stark, Wendelin J.

doi:10.1039/b517501a

Cited by 160 publications

(127 citation statements)

References 29 publications

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“…These scaffolds may constitute the "scaffolds of choice" in future developments and their combination with stem cells is of high interest [62,[224][225][226]. The use of bioactive glass and glass ceramic nanoparticles [10,44] and carbon nanotubes (CNTs) [89,227,228] as well as their combination with bioresorbable polymers [46][47][48]89,170,229] may also improve the environment to enhance cell attachment, proliferation, angiogenic and osteogenic properties as well as adding extra functionalities to the base scaffold. However, possible toxicity issues associated with nanoparticles and CNTs will have to be comprehensively investigated [89].…”

Section: Discussionmentioning

confidence: 99%

“…Bone tissue engineering is one of the most exciting future clinical applications of bioactive glasses. Both micron-sized and recently nanoscale particles [23,44,45] are considered in this application field, which includes also the fabrication of composite materials, e.g., combination of biodegradable polymers and bioactive glass [38,[46][47][48][49][50], as discussed in detail in §3.2. Bioactive silicate glasses exhibit several advantages in comparison to other bioactive ceramics, e.g., sintered hydroxyapatite, in tissue engineering applications.…”

Section: Figurementioning

confidence: 99%

“…Glass-ceramics are partially crystallized glasses produced by heating the parent bioactive glass above its crystallization temperature, usually at about 610-630 °C [33,44,96,97]. In the case of glass-ceramics obtained by a sintering process, during the occurrence of crystallization and densification, the microstructure of the parent glass shrinks, porosity is reduced and the solid structure gains mechanical strength [70].…”

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

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Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

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Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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“…Nbg were prepared by flame spray method [63] and have been characterized recently [27]. Sodium alginate (Protanal LF 10/60) was from FMC Biopolymers.…”

Section: Methodsmentioning

confidence: 99%

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cattalini

Hoppe

Pishbin

et al. 2015

J. R. Soc. Interface.

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This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu 2þ or Ca 2þ (AlgNbgCu, AlgNbgCa, respectively). Twodimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu 2þ and Ca 2þ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu 2þ or Ca 2þ were developed with potential applications for preparation of multifunctional scaffolds for BTE.

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“…To the authors' knowledge, there is no other technique that allows for synthesizing this kind of multicomponent nanoparticulate bioactive glass. Furthermore, this method guarantees narrow particle size distribution in addition to the low risk of product contamination (Brunner et al, 2006, Teoh et al, 2010.…”

Section: Introductionmentioning

confidence: 99%

Novel strontium-doped bioactive glass nanoparticles enhance proliferation and osteogenic differentiation of human bone marrow stromal cells

et al. 2013

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The present study investigates a new family of bioactive glass nanoparticles with and without Sr-doping focusing on the influence of the nanoparticles on human bone marrow stromal cells (hBMSCs) in vitro. The bioactive glass nanoparticles were fabricated by flame spray synthesis and a particle diameter of 30-35 nm was achieved. Glass nanoparticles were undoped (BG 13-93-0Sr) or doped with 5 wt% strontium (Sr) ) and used at concentrations of 10 and 100 g/cm² (particles per culture plate area), respectively. Cells were cultured for 14 days after which the samples were analysed regarding metabolic activity and expression of various bone-specific genes. Cell growth and morphology indicated the high cytocompatibility of the nanoparticulate bioactive glass. The presence of the nanoparticles enhanced cell growth compared to the plain polystyrene control group. At a concentration of 100 g/cm², Sr-doped particles led to significantly enhanced gene expression of osteocalcin, collagen type 1 and vascular endothelial growth factor. Thus, Sr-doped nanoparticles showing a dose-dependent increase of osteogenic differentiation in hBMSCs are a promising biomaterial for bone regeneration purposes.

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Glass and bioglass nanopowders by flame synthesis

Abstract: The preparation of amorphous nanopowders by flame synthesis opens access to common soda-lime, metal-doped glasses or bioglasses in the range of 20-80 nm and offers an alternative to conventional wet-phase preparation, solid state reactions or melting.

Cited by 160 publications

References 29 publications

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Novel strontium-doped bioactive glass nanoparticles enhance proliferation and osteogenic differentiation of human bone marrow stromal cells

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