Glandular Inclusions in Pelvic and Abdominal Para-aortic Lymph Nodes: A Study of Autopsy and Surgical Material in Males and Females

Karp, Louis A.; Czernobilsky, Bernard

doi:10.1093/ajcp/52.2.212

Cited by 81 publications

(11 citation statements)

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“…37 Such inclusions have also been rarely described in the intraabdominal lymph nodes of men. 37 Such inclusions have also been rarely described in the intraabdominal lymph nodes of men.…”

Section: Epithelial-type Inclusionsmentioning

confidence: 99%

Lymph Nodes

Chang¹,

Arber²,

Weiss³

2009

Modern Surgical Pathology

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“…37 Such inclusions have also been rarely described in the intraabdominal lymph nodes of men. 37 Such inclusions have also been rarely described in the intraabdominal lymph nodes of men.…”

Section: Epithelial-type Inclusionsmentioning

confidence: 99%

Lymph Nodes

Chang¹,

Arber²,

Weiss³

2009

Modern Surgical Pathology

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“…These are almost always incidental microscopic findings [20][21][22] . They are most commonly lined by a single layer of cuboidal to columnar tubal-type epithelium (endosalpingiosis), but sometimes by benign endometrioid epithelium 23 , mucinous epithelium of endocervical [24][25] or goblet-cell type 26 , or metaplastic squamous epithelium 27 ; an admixture of different types of müllerian glands within a lymph node is designated as müllerianosis.…”

Section: Discussionmentioning

confidence: 99%

Endometriosis with an aberrant immunophenotype: Challenging differential diagnosis of glandular lesions in the pelvic lymph nodes

Vlckova¹,

Lenz

Chvatal³

et al. 2017

BIOMED PAP

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f Case report. We describe an unusual case of pelvic lymph node endometriosis with an aberrant immunophenotype mimicking metastasis of adenocarcinoma. A 37-year-old patient with a history of invasive cervical adenocarcinoma stage pT1a2 is presented. Due to insufficient loop electrosurgical excision procedure (LEEP) conization, total laparoscopic hysterectomy with pelvic lymphadenectomy was indicated. Intraoperatively, the diagnosis of deep infiltrating endometriosis of parametrial ligament and vesicouterine pouch, endometrioma of the left ovary and Allen Master's syndrome was suspected; the patient had no history or clinical symptoms of endometriosis. A PubMed search of similar cases was followed by a comparison to this case and discussion of the differential diagnosis of glandular lesions in the pelvic lymph nodes is reported. Results. Histological investigation showed no residual neoplasia; the diagnosis of endometriosis was confirmed. An interesting microscopic finding was represented by a solitary glandular lesion in one pelvic lymph node. Using immunohistochemistry, it was demonstrated that there was a complete loss of oestrogen and progesterone receptor expression (unlike parametrial ligament endometriosis). The diagnosis of endometriosis was based on the presence of endometrial stroma; malignancy was excluded by bland cytomorphologic features and results of immunohistochemical examination.Conclusions. This type of aberrant of the endometriotic gland immunophenotype has never been presented in the scientific literature before. This finding plays a significant role from the pathology standpoint and, perhaps more importantly, from the clinical standpoint. An asymptomatic patient with a correct diagnosis of lymph node endometriosis did not undergo excessive treatment for false positive diagnosis of metastatic cervical adenocarcinoma.

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“…In 4-15% of cases these lesions can be found in one or more lymph nodes whenever lymph nodes are removed due to gynecological disease [9,5].…”

Section: Discussionmentioning

confidence: 99%

Glandular inclusions in lymph nodes: pattern of distribution and metaplastic transformation

Maaßen¹,

Hiller²

1994

Arch Gynecol Obstet

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Pelvic and paraaortal lymph nodes of 499 gynecologic cancer patients were screened for the occurrence of metaplastic changes and their topographic pattern. Glandular inclusions in lymph nodes were distributed evenly across all lymphatic areas and there was no correlation to the extent and the kind of carcinoma. In most cases the benign nature of these inclusions was obvious even in the presence of metaplasias and there was no difficulty in differentiating them from metastases.

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Glandular Inclusions in Pelvic and Abdominal Para-aortic Lymph Nodes: A Study of Autopsy and Surgical Material in Males and Females

Cited by 81 publications

References 0 publications

Lymph Nodes

Lymph Nodes

Endometriosis with an aberrant immunophenotype: Challenging differential diagnosis of glandular lesions in the pelvic lymph nodes

Glandular inclusions in lymph nodes: pattern of distribution and metaplastic transformation

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