Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer

Jamwal, Ashiya; Chand, Jagdish; Dash, Anshurekha; Bhatt, Shipra; Dhiman, Sumit; Wazir, Priya; Singh, Buddh; Goswami, Anindya; Nandi, Utpal

doi:10.1016/j.cbi.2023.110605

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Similar to glycitein (7), this flavonoid modulates ERs, with a proliferative effect at lower concentrations and an antiproliferative effect at higher concentrations [293]. In an animal model of TNBC, glabridin combined with a low concentration of paclitaxel significantly reduced the tumor burden and the formation of lung metastases [294]. Glabrene (11), also present in licorice, has a higher affinity for ERs and a dual effect on BC cells; at lower concentrations (10 nM-10 µM), it promotes ER-dependent growth, while at higher concentrations (>15 µM) it shows ER-independent antiproliferative activity [293].…”

Section: Isoflavonoidsmentioning

confidence: 99%

Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer

da Silva,

Brandão,

Ferreira

et al. 2023

Pharmaceuticals

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Breast cancer (BC) is the most diagnosed cancer worldwide, mainly affecting the epithelial cells from the mammary glands. When it expresses the estrogen receptor (ER), the tumor is called luminal BC, which is eligible for endocrine therapy with hormone signaling blockade. Hormone therapy is essential for the survival of patients, but therapeutic resistance has been shown to be worrying, significantly compromising the prognosis. In this context, the need to explore new compounds emerges, especially compounds of plant origin, since they are biologically active and particularly promising. Natural products are being continuously screened for treating cancer due to their chemical diversity, reduced toxicity, lower side effects, and low price. This review summarizes natural compounds for the treatment of luminal BC, emphasizing the activities of these compounds in ER-positive cells. Moreover, their potential as an alternative to endocrine resistance is explored, opening new opportunities for the design of optimized therapies.

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Section: Isoflavonoidsmentioning

confidence: 99%

Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer

da Silva,

Brandão,

Ferreira

et al. 2023

Pharmaceuticals

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Toxic Features and Metabolomic Intervention of Glabrene, an Impurity Found in the Pharmaceutical Product of Glabridin

Li,

Jiang,

Guo

et al. 2024

IJMS

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Glabridin is a widely used product in the cosmetics and pharmaceutical industry, which is generally isolated and purified from Licorice (Glycyrrhiza glabra) extract in industrial production. It has wide clinical applications, but significant toxicity has also been reported. The purity of glabridin raw material is generally between 90% and 98%. We have identified a toxic impurity, glabrene, in the industrial product glabridin. Our investigation using an AB wild-type zebrafish toxicity test showed that glabrene has a significant lethal effect with an LC10 of 2.8 μM. Glabrene induced obvious malformation and disrupted cartilage development in zebrafish larvae. Furthermore, the compound significantly reduced larval mobility and caused damage to brain neural tissues. Metabolic pathway analysis and neurotransmitter quantification via ELISA indicated abnormal activation of the phenylalanine metabolic pathway, resulting in elevated dopamine and acetylcholine levels in vivo. These findings provide insights into the potential risks of glabrene contamination and offer a new reference point for enhancing safety measures and quality controls in licorice-derived products.

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Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer

Cited by 2 publications

References 67 publications

Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer

Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer

Toxic Features and Metabolomic Intervention of Glabrene, an Impurity Found in the Pharmaceutical Product of Glabridin

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