Glabridin, an isoflavan from licorice root, ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice

Li, Penghui; Li, Yonglian; Jiang, Hong; Xu, Yuting; Li, Xiaoying; Che, Biao; Tang, Jian; Liu, Guangrong; Tang, Yadong; Zhou, Wei; Zhang, Langyue; Dong, Chang‐Zhi; Chen, Huixiong; Zhang, Kun; Du, Zhiyun

doi:10.1016/j.intimp.2018.04.018

Cited by 38 publications

(24 citation statements)

References 34 publications

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“…ELISA MAX™ Deluxe (BioLegend) were used to determine the levels of IL‐6 and IL‐1β in the supernatants of HaCaT cells according to manufacturer's specification as described previously 19 …”

Section: Methodsmentioning

confidence: 99%

“…ELISA MAX™ Deluxe (BioLegend) were used to determine the levels of IL-6 and IL-1β in the supernatants of HaCaT cells according to manufacturer's specification as described previously. 19 Mice in the control group were only topically applied with water and mice in the AEW group received acetone/diethylether (AE = 1:1) and water following AE once a day for 5 days. The EAP group and the HA group were topically applied with AE (1:1) and water following AE, and then, after 4 hours EAP or HA dissolved in water was administered at a dose of 10 or 2 mg/d, respectively, for 5 days.…”

Section: Elisa Assaymentioning

confidence: 99%

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Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Wang

Tai

Zhang

et al. 2020

J of Cosmetic Dermatology

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Background Dry skin is a common skin condition caused by reduction of water‐holding capacity, which is regulated by skin barrier function. Dry skin can also be a symptom that indicates a more serious diagnosis. There are a number of moisturizers on the market, which play an important role in dermatologic and cosmetic therapies. However, the demand for these products with good and therapeutic efficiency is still growing. Aims It remains necessary to investigate the effects of Elaeagnus L gum polysaccharides (EAP), which are prepared from gum of Elaeagnus angustifolia L. on the epidermal permeability barrier function and their possible underlying mechanisms. Patients/Methods EAP were purified, analyzed, and tested on human keratinocyte cell line (HaCaT) and then on the skin in vivo to evaluate their antiinflammatory activities and their impacts on impaired skin barrier function. Results Histological analyses revealed that topical administration with EAP effectively attenuated dryness‐like skin condition, including less percutaneous water loss rate, less infiltrate inflammation cells, and less epidermal thickening. Moreover, EAP inhibited the production of various inflammatory mediators and increased AQP‐3, FLG, and LOR expression. Conclusion Our results indicated that EAP enhances epidermal permeability barrier function, and they can be used as a promising adjuvant agent in skin care cosmetics and in treating some skin disorders characterized by cutaneous inflammation and abnormal barrier function.

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Section: Methodsmentioning

confidence: 99%

Section: Elisa Assaymentioning

confidence: 99%

Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Wang

Tai

Zhang

et al. 2020

J of Cosmetic Dermatology

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“…Because OS-dependent angiogenesis is an important contributor to the progression of cancers, antioxidants may overcome the limitations of anti-VEGF therapy, especially in relation to tumor resistance. Related documents revealed that glabridin ameliorated imiquimod-induced psoriasis-like inflammation on BALB/c mice skin through improvement of antioxidant status and downregulation of proinflammatory cytokines [158]. By decreasing lipid peroxidation and modulating Ca 2+ release, colchicine significantly induced protective effects on OS in the neutrophils of BD patients [159].…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

Emerging Roles of Redox-Mediated Angiogenesis and Oxidative Stress in Dermatoses

Xian

Song

Yang

et al. 2019

Oxidative Medicine and Cellular Longevity

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Angiogenesis is the process of new vessel formation, which sprouts from preexisting vessels. This process is highly complex and primarily involves several key steps, including stimulation of endothelial cells by growth factors, degradation of the extracellular matrix by proteolytic enzymes, migration and proliferation of endothelial cells, and capillary tube formation. Currently, it is considered that multiple cytokines play a vital role in this process, which consist of proangiogenic factors (e.g., vascular endothelial growth factor, fibroblast growth factors, and angiopoietins) and antiangiogenic factors (e.g., endostatin, thrombospondin, and angiostatin). Angiogenesis is essential for most physiological events, such as body growth and development, tissue repair, and wound healing. However, uncontrolled neovascularization may contribute to angiogenic disorders. In physiological conditions, the above promoters and inhibitors function in a coordinated way to induce and sustain angiogenesis within a limited period of time. Conversely, the imbalance between proangiogenic and antiangiogenic factors could cause pathological angiogenesis and trigger several diseases. With insights into the molecular mechanisms of angiogenesis, increasing reports have shown that a close relationship exists between angiogenesis and oxidative stress (OS) in both physiological and pathological conditions. OS, an imbalance between prooxidant and antioxidant systems, is a cause and consequence of many vascular complains and serves as one of the biomarkers for these diseases. Furthermore, emerging evidence supports that OS and angiogenesis play vital roles in many dermatoses, such as psoriasis, atopic dermatitis, and skin tumor. This review summarizes recent findings on the role of OS as a trigger of angiogenesis in skin disorders, highlights newly identified mechanisms, and introduces the antiangiogenic and antioxidant therapeutic strategies.

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“…13 Previous studies also found that antioxidants can improve the symptoms of psoriasis. 10,[14][15][16][17][18][19] These results suggest that our system has a potential application in psoriasis therapy by suppressing ROS and protecting cells from oxidative stress.…”

Section: Sod-and Catalase-mimicking Activity Of β-Cds/ceo 2 Npsmentioning

confidence: 61%

“…11,13 Therefore, antioxidative strategies eradicating ROS may serve as effective and easy treatment options for psoriasis. 14 Antioxidants, such as epigallocatechin-3-gallate, 15 glabridin, 16 proanthocyanidins, 17 polyandric acidA 18 and other natural compounds 19,20 with beneficial effects on cutaneous psoriasis have been reported.…”

Section: Introductionmentioning

confidence: 99%

<p>Cyclodextrin-Modified CeO<sub>2</sub> Nanoparticles as a Multifunctional Nanozyme for Combinational Therapy of Psoriasis</p>

Wu¹,

Liu²,

Wang³

et al. 2020

IJN

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Reactive oxygen species (ROS)-induced oxidative stress plays a key role in the pathogenesis and progression of psoriasis by causing inflammation. Antioxidative strategies eradicating ROS may serve as effective and easy treatment options for psoriasis, while nanozymes with intrinsic antioxidant enzyme-like activity have not been explored for psoriasis treatment. The aim of this study is to fabricate β-cyclodextrins (β-CDs)-modified ceria nanoparticles (β-CDs/CeO 2 NPs) with drug-loaded and multimimic-enzyme activities for combinational psoriasis therapy. Methods: The β-CDs/CeO 2 NPs were synthesized by a hydrothermal method using unmodified β-CDs as a protecting agent. The structure, size and morphology were analyzed by dynamic light scattering, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopy. Considering the superoxide dismutase (SOD)-and catalase-mimetic activities, the in vitro antioxidant activity of the β-CDs/CeO2 NPs was investigated. After dithranol (DIT) was loaded, the drug-loading capacity and release profile were determined by UV-visible light spectrophotometer and high-performance liquid chromatography. The anti-psoriatic efficacy was studied in the imiquimod (IMQ)-induced mouse model on the basis of morphological evaluation, psoriasis area and severity index calculation (PASI), and inflammatory cytokine expression. Results: The average particle size of the blank β-CDs/CeO 2 NPs was 60.89±0.32 nm with a polydispersity index (PDI) of 0.12, whereas that of the DIT-loaded NPs was 79.38±1.06 nm with a PDI of 0.27. TEM results showed the as-prepared NPs formed a uniform quasispherical shape with low polydispersity. XPS indicates synthesized NPs have a mixed Ce 3 + /Ce 4+ valence state. FTIR spectroscopy confirmed the presence of β-CDs and DIT in the NPs. Inhibition of superoxide anion rate by NPs could be reached to 79.4% in the presence of 200 µg/mL, and elimination of H 2 O 2 efficiency reached about 50% in the presence of 40 µg/ mL, demonstrating excellent superoxide dismutase-and catalase-mimicking activities, thereby providing remarkable cryoprotection against ROS-mediated damage. Furthermore, β-CDs on the surface endowed the NPs with drug-loading function via host-guest interactions. The entrapment efficiency and drug loading of DIT are 94.7% and 3.48%, respectively. The in vitro drug release curves revealed a suitable release capability of DIT@β-CDs/CeO 2 NPs under physiological conditions. In IMQ-induced psoriatic model, the DIT@β-CDs/CeO 2 NPs exhibited excellent therapeutic effect. Conclusion: This study may pave the way for the application of nanozyme β-CDs/CeO 2 NPs as a powerful tool for psoriasis therapy.

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Glabridin, an isoflavan from licorice root, ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice

Cited by 38 publications

References 34 publications

Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice

Emerging Roles of Redox-Mediated Angiogenesis and Oxidative Stress in Dermatoses

<p>Cyclodextrin-Modified CeO<sub>2</sub> Nanoparticles as a Multifunctional Nanozyme for Combinational Therapy of Psoriasis</p>

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