Landslide is a serious geo-hazard that poses destruction and loses of life in different part of the world. The severity of the problem is higher in developing countries like Ethiopia. This study is aimed at assessing the spatial landslide susceptibility in the upper Didessa sub-basin using GIS and multi criteria evaluation (MCE) techniques. In order to reach this objective both primary (field survey) and secondary data (expert interview, literature, remote sensing data, digital soil map and geological map) were obtained from various source. Eleven landslide causative factor identified in this research are slope, aspect, drainage density, topographic wetness index (TWI), stream power index (SPI), topographic ruggedness index, hypsometric integral, lithology, LULC, soil texture, and distance from road. The analytical hierarchy process (AHP) method was employed to identify the weight of each indicator from the pairwise comparison matrix. The weighted linear combination was then used to generate landslide susceptibility map (LSM). Based on landslide susceptibility, the study area was classified into very high, high, moderate, low, and very low susceptibility zones. Finally, based on the eleven-landslide causative factor analysis, about 24% of the study area is moderately susceptible, while 12% and 6% were classified as high and very high susceptibility to landslides, respectively. The results of this study could help decision makers for future landslide hazardous preventions and mitigation strategies.