Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis

Yang, Xiaolai; Guo, Tiankang; Wang, Yanhong; Huang, Yanhui; Liu, Xia; Wang, Xiaoxia; Wan, Li; Zhao, Xin; Wang, Liping; Yan, Shuai; Wu, Di; Wu, Yongjie

doi:10.1016/j.intimp.2011.12.014

Cited by 54 publications

(31 citation statements)

References 45 publications

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“…The phytochemical analysis performed in our study showed that the P. paniculata extract contained a series of compounds belonging to these chemical classes. These substances have been found to be responsible for a number of biological activities, such as analgesic and anti-inflammatory properties [31,[59][60][61][62], as well as antitumour effects [28,[63][64][65][66]. Importantly, none of the phytochemical analyses showed the presence of β-ecdysterone in the studied extract (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…This reduction in MPO activity may be related to a decrease in inflammatory cell infiltration as a consequence of the anti-inflammatory effects of the compounds contained in the P. paniculata extract. These compounds are chemically similar to the ginsenosides, which are substances with demonstrated antiinflammatory actions according to studies by [61,62,[75][76][77].…”

Section: Discussionmentioning

confidence: 99%

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Anti-inflammatory effects of Brazilian ginseng (Pfaffia paniculata) on TNBS-induced intestinal inflammation: Experimental evidence

Costa

Tanimoto

Quaglio

et al. 2015

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of Brazilian ginseng (Pfaffia paniculata) on TNBS-induced intestinal inflammation: Experimental evidence

Costa

Tanimoto

Quaglio

et al. 2015

International Immunopharmacology

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“…Interestingly, ginsenoside Rd, which is present in AG whole extract (extracted with aqueous ethanol) and absent in the HAG, has been shown to attenuate the inflammatory response to TNBS − (2,4,6-trinotrobenzenesulfonic acid-) induced colitis by down-regulating multiple pro-inflammatory cytokines through the modulation of JNK (c-Jun N-terminal kinase) and p38 activation [47]. Similarly another ginsenoside not present in HAG, Rb1, and its metabolite compound K after oral administration blocked TNBS-induced expression of iNOS (inducible-nitric oxide synthase), Cox-2 (cyclooxygenase-2), and NF- κβ (nuclear transcription factor κβ ) activation in mice [48].…”

Section: Discussionmentioning

confidence: 99%

A Limited Role of p53 on the Ability of a Hexane Fraction of American Ginseng to Suppress Mouse Colitis

Poudyal

Cui

et al. 2012

Journal of Biomedicine and Biotechnology

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Ulcerative colitis (UC) is debilitating and carries a high colon cancer risk. Apoptosis of inflammatory cells is a key mechanism regulating UC. We have recently shown that American ginseng (AG), and to a greater extent, a Hexane fraction of AG (HAG) can cause apoptosis and suppress mouse colitis through a p53-mediated mechanism. Here, we tested the hypothesis that HAG suppresses colitis through a p53 mechanism. We found only a limited impact of p53 in the ability of HAG to induce inflammatory cell apoptosis and suppress mouse colitis in vitro and in vivo. Finally, we asked whether HAG could cause cell cycle arrest of HCT116 colon cancer cells in vitro. Interestingly, HAG caused a G1 arrest of such cells independent of p53 status. Findings are significant because HAG suppresses colitis and associated colon cancer, and mutation in p53 is observed in most colitis-driven colon cancers. Therefore, HAG might be very effective in targeting the inflammatory cells and cancer cells since it induces apoptosis of inflammatory cells and cell cycle arrest in both p53−/− and WT p53 colon cancer cells.

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“…Ginsenoside compound K (CK) was shown to promote recovery of DSS-induced colitis by suppressing NF-kB activation . Ginsenoside Rd can attenuate 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis via modulating mitogen-activated protein kinase signaling pathways (Yang et al, 2012b). Ginseng has also been suggested as an anti-inflammatory agent or adjuvant treatment of the patients of IBD (Hofseth and Wargovich, 2007).…”

Section: Introductionmentioning

confidence: 99%

Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium–Induced Colitis

et al. 2015

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Pregnane X receptor (PXR) activation exhibits anti-inflammatory effects via repressing nuclear factor-kB (NF-kB); however, its overactivation may disrupt homeostasis of various enzymes and transporters. Here we found that ginsenosides restore PXR/NFkB signaling in inflamed conditions without disrupting PXR function in normal conditions. The effects and mechanisms of ginsenosides in regulating PXR/NF-kB signals were determined both in vitro and in vivo. Ginsenosides significantly inhibited NFkB activation and restored the expression of PXR target genes in tumor necrosis factor-a-stimulated LS174T cells. Despite not being PXR agonists, ginsenosides repressed NF-kB activation in a PXR-dependent manner. Ginsenosides significantly increased the physical association between PXR and the NF-kB p65 subunit and thereby decreased the nuclear translocation of p65. Ginsenoside Rb1 and compound K (CK) were major bioactive compounds in the regulating PXR/NF-kB signaling. Consistently, ginsenosides significantly attenuated dextran sulfate sodium-induced experimental colitis, which was associated with restored PXR/NF-kB signaling. This study indicates that ginsenosides may elicit antiinflammatory effects via targeting PXR/NF-kB interaction without disrupting PXR function in healthy conditions. Ginsenoside Rb1 and CK may serve as leading compounds in the discovery of new drugs that target PXR/NF-kB interaction in therapy for inflammatory bowel disease.

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Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis

Cited by 54 publications

References 45 publications

Anti-inflammatory effects of Brazilian ginseng (Pfaffia paniculata) on TNBS-induced intestinal inflammation: Experimental evidence

Anti-inflammatory effects of Brazilian ginseng (Pfaffia paniculata) on TNBS-induced intestinal inflammation: Experimental evidence

A Limited Role of p53 on the Ability of a Hexane Fraction of American Ginseng to Suppress Mouse Colitis

Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium–Induced Colitis

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