Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction

Zhou, Ping; Deng, Fei; Yang, Zhongping; Cao, Canhui; Zhao, Haiquan; Liu, Fen-Ting; Zhong, Ke; Fu, Lin; Peng, Tianliu; Sun, Di; Liu, Hui; Li, Rong; Yu, Yang

doi:10.1007/s11427-021-2080-x

Cited by 14 publications

(11 citation statements)

References 39 publications

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“…AKT1, SRC, EGFR, and JUN were all critical inflammatory response targets. AKT could be phosphorylated by ROS activation, which mediates various biological effects such as inflammation, autophagy and apoptosis, and several herbal medicines have been shown to treat inflammation by inhibiting AKT phosphorylation [20,21] . The SRC family is a group of non‐receptor tyrosine kinases that are abundantly expressed in epithelial cells and can be activated by ROS.…”

Section: Discussionmentioning

confidence: 99%

“…AKT could be phosphorylated by ROS activation, which mediates various biological effects such as inflammation, autophagy and apoptosis, and several herbal medicines have been shown to treat inflammation by inhibiting AKT phosphorylation. [20,21] The SRC family is a group of non-receptor tyrosine kinases that are abundantly expressed in epithelial cells and can be activated by ROS. SRC activation phosphorylates EGFR tyrosine at position 845 and activates the EGFR/MAPK signaling cascade, leading to an inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

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Network Pharmacology and Molecular Docking Reveal the Mechanism of Corydalis saxicola Bunting Total Alkaloids in Treating Radiation‐Induced Oral Mucositis

Lai

Yong

Wei

et al. 2023

Chemistry & Biodiversity

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The study aims to explore the effect and mechanism of total alkaloids of Corydalis saxicola Bunting (CSBTA) in the treatment of radiation induced oral mucositis (RIOM) through network pharmacology and molecular docking. The components and corresponding targets of Corydalis saxicola Bunting were screened by literature review. RIOM related targets were obtained in GeneCards. Cytoscape software was used to construct the component‐target‐pathway network. Protein‐Protein Interaction (PPI) networks was constructed by String database. GO and KEGG enrichment analyses were performed by Metascape. AutoDock Vina 4.2 software was used for molecular docking. There were 26 components of CSBTA targeting 61 genes related to RIOM. Through Cytoscape and PPI analysis, 15 core target genes of CSBTA for treating RIOM were identified. GO functional analysis indicated that CSBTA might play a role through kinase binding and protein kinase activation. KEGG pathway analysis showed that the core targets of CSBTA were mainly focused on cancer and reactive oxygen species (ROS) pathway. The results of molecular docking showed that CSBTA had strong binding energy with target protein including SRC, AKT and EGFR. The study demonstrates that CSBTA may treat RIOM by affecting SRC, AKT and EGFR through ROS pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking Reveal the Mechanism of Corydalis saxicola Bunting Total Alkaloids in Treating Radiation‐Induced Oral Mucositis

Lai

Yong

Wei

et al. 2023

Chemistry & Biodiversity

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“…AKT is a critical protein kinase B regulating cell survival, inflammation, oxidative stress, and cell death, playing a crucial role in solid organ injury [ 16 ]. Phosphorylated Foxo1 could be dephosphorylated to form Foxo1 once AKT is activated, leading to its nuclear translocation [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Then, the activated immune system further generates reactive oxygen species (ROS) and cytokines which can further give rise to worsening lung injury [12]. AKT/Foxo1 signaling pathway possesses multiple regulators as well as effectors including glucose, insulin, cytokines, and growth factors, displaying significant functions in cell survival, metabolism, inflammation, and oxidative stress [13][14][15][16]. Previous studies have demonstrated that changes in AKT activity levels in macrophages show significant impacts on polarization and activation of macrophages via regulating Foxo1 activity during ARDS [17,18].…”

Section: Introductionmentioning

confidence: 99%

Attenuation of the Severity of Acute Respiratory Distress Syndrome by Pomiferin through Blocking Inflammation and Oxidative Stress in an AKT/Foxo1 Pathway-Dependent Manner

Tang

Yang

Feng

et al. 2022

Oxidative Medicine and Cellular Longevity

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Acute respiratory distress syndrome (ARDS) gives rise to uncontrolled inflammatory response and oxidative stress, causing very high mortality globally. Pomiferin is a kind of prenylated isoflavonoid extracted from Maclura pomifera, owning anti-inflammatory and antioxidant properties. However, the functions and possible mechanisms of pomiferin in lipopolysaccharide- (LPS-) induced ARDS remain unknown. C57BL/6 mice were injected with LPS (5 mg/kg) intratracheally to induce an in vivo ARDS model while RAW264.7 macrophages were stimulated with LPS (100 ng/ml) to induce an in vitro model. Our data demonstrated that pomiferin (20 mg/kg) significantly improved pulmonary function and lung pathological injury in mice with ARDS, apart from increasing survival rate. Meanwhile, pomiferin treatment also inhibited LPS-induced inflammation as well as oxidative stress in lung tissues. LPS stimulation significantly activated AKT/Foxo1 signal pathway in lung tissues, which could be reversed after pomiferin treatment. In vitro experiments further showed that 10, 20, and 50 μM of pomiferin could enhance cell viability of RAW264.7 macrophages stimulated with LPS. What is more, 3-deoxysappanchalcone (3-DE), one AKT agonist, was used to active AKT in RAW264.7 macrophages. The results further showed that 3-DE could abolish pomiferin-elicited protection in LPS-treated RAW264.7 macrophages, evidenced by activated inflammation and oxidative stress. Taken together, our study showed that pomiferin could exert an ARDS-protective effect by blocking the AKT/Foxo1 signal pathway to inhibit LPS-induced inflammatory response and oxidative injury, which may serve as a potential candidate for the treatment of ARDS in the future.

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“…29 Rg1, Rb1, Rg3 and Rh3 were shown to attenuate D-gal-induced damage to organs, including spleen, thymus, liver, kidneys, pancreas, ovary and endometrium, by regulating oxidative stress. 26,[30][31][32][33][34][35] Furthermore, ginsenosides were shown to be able to modulate AKT and NRF2 signaling pathways for protecting organs from oxidative stress damage. For example, Rg1 enhances the antioxidant capacity of cells and reduces DNA damage by activating the NRF2 signaling pathway.…”

Section: Antioxidant Activitymentioning

confidence: 99%

The anti-aging mechanism of ginsenosides with medicine and food homology

Tian,

Ko,

Luo

et al. 2023

Food Funct.

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Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction

Cited by 14 publications

References 39 publications

Network Pharmacology and Molecular Docking Reveal the Mechanism of Corydalis saxicola Bunting Total Alkaloids in Treating Radiation‐Induced Oral Mucositis

Network Pharmacology and Molecular Docking Reveal the Mechanism of Corydalis saxicola Bunting Total Alkaloids in Treating Radiation‐Induced Oral Mucositis

Attenuation of the Severity of Acute Respiratory Distress Syndrome by Pomiferin through Blocking Inflammation and Oxidative Stress in an AKT/Foxo1 Pathway-Dependent Manner

The anti-aging mechanism of ginsenosides with medicine and food homology

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