Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats

Liu, Lei; Hoang-Gia, Trinh; Wu, Hui; Lee, Mi-Ra; Gu, Lijuan; Wang, Chunyan; Yun, Beom-Sik; Wang, Qijun; Ye, Shengquan; Sung, Chang‐Keun

doi:10.1016/j.brainres.2011.01.051

Cited by 62 publications

(49 citation statements)

References 50 publications

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“…Furthermore, increasing evidence has shown that EA can attenuate cognitive deficits by means of maintaining sympatheticparasympathetic balance, inhibiting apoptosis (Shufang, 2010) and neuroinflammation (Jun, 2007) as well as regulating cell proliferation (Liu et al, 2011) in the hippocampus. But a few conflict reports appeared that EA made no sense in POCD (Yang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The effects of electroacupuncture treatment on the postoperative cognitive function in aged rats with acute myocardial ischemia–reperfusion

Yuan

Zhang

et al. 2014

Brain Research

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Section: Introductionmentioning

confidence: 99%

The effects of electroacupuncture treatment on the postoperative cognitive function in aged rats with acute myocardial ischemia–reperfusion

Yuan

Zhang

et al. 2014

Brain Research

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“…Increasing evidence demonstrates that Rb1 can protect against neuronal injury with the properties of anti-inflammation, anti-apoptosis and induction of neurogenesis [10-12]. Besides, recent studies have also indicated that Rb1 can increase cell genesis in hippocampal subregions to improve the spatial learning and memory of rats [13]. However, the neuroprotective properties of Rb1 in epilepsy are still elusive.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling

Shi

Wang

Teng

et al. 2018

Cell Physiol Biochem

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Background/Aims: Ginsenoside Rb1 (Rb1) has been reported to have varieties of neuroprotective effects. This study aimed to evaluate the effects of Rb1 on pentylenetetrazol (PTZ)-induced rat brain injury and Mg²⁺ free-induced neuron injury and analyzed the detailed molecular mechanisms in vivo and in vitro. Methods: Seizure duration and latency were measured in epilepsy kindled rat. The cognitive impairment was assessed by Morris water maze (MWM) test. Oxidative stress parameters, malondialdehyde (MDA) and glutathione (GSH) were measured by the 2-thiobarbituric acid methods and the DTNB-GSSG reductase recycling methods. Neuronal damage was assessed by hematoxylin and eosin (H&E) and Nissl staining. Neuronal apoptosis was measured by Annexin V-FITC and propidium iodide (PI) staining. Immunohistochemistry and immunofluorescence staining were performed to evaluate Nrf2 and HO-1 expressions. Expression of Nrf2, HO-1, Bcl-2, iNOS and LC3 were evaluated by western blot. Results: The PTZ-injured rats presented longer seizure duration and shorter seizure latency. Rb1 ameliorated these effects, as well as the cognitive deficits caused by PTZ exposure. Besides, Rb1 dose-dependently increased GSH levels, decreased MDA levels and alleviated neuronal damage in PTZ-treated rats. In vitro, Rb1 increased cell viability and decreased neuronal apoptosis in a dose-dependent manner under Mg²⁺ free condition. Moreover, in vivo and in vitro, Rb1 enhanced both the Nrf2 and HO-1 expressions. Furthermore, upregulation of the expression of Bcl-2 and downregulation of the expression of iNOS and LC3 were observed. However, knockdown of Nrf2 adversely affected the protective effects of Rb1 in epileptic hippocampal neurons. Conclusion: Rb1 conferred neuroprotective effects against PTZ-induced brain damage and Mg²⁺ free-induced neuron injury by activating Nrf2/ARE signaling.

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“…Ginsenoside Rh2 recovers the scopolamine-induced reduction in long-term potentiation (LTP) in the hippocampal CA1 area [25]. Rb1 enhances the stimulatory effect of neurite outgrowth [26], promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway [27], upregulates cell genesis in the dentate gyrus (DG) and CA3 hippocampal subregions [28]. Traditionally, two types of ginseng have been used: white ginseng, which is air-dried ginseng, and red ginseng, which is produced by steaming raw ginseng at 98-100 °C for 2-3 h [29].…”

Section: Panax Ginsengmentioning

confidence: 99%

“…C. officinale has been shown to improve memory in scopolamine-injected mice [101]. Several formulations containing C. officinale have been showed to improve memory impairment in cerebral ischemia [102,103], Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) -injected mice [104] and Tg-APPswe/PS1dE9, transgenic mice of AD [105].…”

Section: Miscellaneous Tkm Plantsmentioning

confidence: 99%

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

Kumar

Song

et al. 2013

Molecules

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Abstract:Hanbang, the Traditional Korean Medicine (TKM), is an inseparable component of Korean culture both within the country, and further afield. Korean traditional herbs have been used medicinally to treat sickness and injury for thousands of years. Oriental medicine reflects our ancestor's wisdom and experience, and as the elderly population in Korea is rapidly increasing, so is the importance of their health problems. The proportion of the population who are over 65 years of age is expected to increase to 24.3% by 2031. Cognitive impairment is common with increasing age, and efforts are made to retain and restore the cognition ability of the elderly. Herbal materials have been considered for this purpose because of their low adverse effects and their cognitive-enhancing or anti-dementia activities. Herbal materials are reported to contain several active compounds that have effects on cognitive function. Here, we enumerate evidence linking TKMs which have shown benefits in memory improvements. Moreover, we have also listed Korean herbal formulations which have been the subject of scientific reports relating to memory improvement.

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Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats

Cited by 62 publications

References 50 publications

The effects of electroacupuncture treatment on the postoperative cognitive function in aged rats with acute myocardial ischemia–reperfusion

The effects of electroacupuncture treatment on the postoperative cognitive function in aged rats with acute myocardial ischemia–reperfusion

Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

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