The effects of electroacupuncture treatment on the postoperative cognitive function in aged rats with acute myocardial ischemia–reperfusion

Yuan, Shaoting; Zhang, Xuezhong; Bo, Yacong; Li, Wenzhi; Zhang, Hongyuan; Jiang, Qingqing

doi:10.1016/j.brainres.2014.10.005

Cited by 42 publications

(29 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar findings were revealed in a study conducted by da Silva and colleagues [43], where they demonstrated that MA resulted in analgesic and anti-inflammatory effects in a rat model of muscle pain, accompanied by an M1 to M2 shift in the macrophage population and increased IL-10 expression levels. These findings are consistent with those in four other studies, where acupuncture improved cognition in rats that received various types of surgery and suppressed systemic inflammation and neuroinflammation [34].…”

Section: Attenuation Of Systemic Inflammation Andsupporting

confidence: 93%

“…Clinical trials have revealed that acupuncture can attenuate surgery-induced elevation of serum proinflammatory factors, such as IL-1β, IL-6, and TNF-α (please refer to Table 1). Since these cytokines are known to be associated with cognitive decline [28,29], the clinical data appears to support a role for acupuncture in the suppression of systemic inflammation during POCD [34]. Similar findings have been observed in animals [35][36][37].…”

Section: Attenuation Of Systemic Inflammation Andsupporting

confidence: 67%

See 1 more Smart Citation

Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

Zhao

Yeung

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Postoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both patients and their families. Acupuncture has been suggested as an effective intervention for many neurological disorders. In recent years, there are increasing interest in the use of acupuncture to prevent and treat POCD. In this review, we summarized the clinical and preclinical evidence of acupuncture on POCD using a narrative approach and discussed the potential mechanisms involved. The experimental details and findings of studies were summarized in tables and analyzed. Most of the clinical studies suggested that acupuncture before surgery could reduce the incidence of POCD and reduce the levels of systematic inflammatory markers. However, their reliability is limited by methodological flaws. Animal studies showed that acupuncture reduced cognitive impairment and the associated pathology after various types of surgery. It is possible that acupuncture modulates inflammation, oxidative stress, synaptic changes, and other cellular events to mitigate POCD. In conclusion, acupuncture is a potential intervention for POCD. More clinical studies with good research design are required to confirm its effectiveness. At the same time, findings from animal studies will help reveal the protective mechanisms, in which systematic inflammation is likely to play a major role.

show abstract

Section: Attenuation Of Systemic Inflammation Andsupporting

confidence: 93%

Section: Attenuation Of Systemic Inflammation Andsupporting

confidence: 67%

Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

Zhao

Yeung

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Accumulating evidence supports that EA can rectify the dysregulation of the HPA axis . EA has been used in many instances in TCM, for example, pain , obesity , sepsis , and surgery . EA can maintain homeostasis by promoting the ability of the organism to cope with the stressor.…”

Section: Discussionmentioning

confidence: 99%

Arginine Vasopressin and Arginine Vasopressin Receptor 1b Involved in Electroacupuncture-Attenuated Hypothalamic-Pituitary-Adrenal Axis Hyperactivity in Hepatectomy Rats

Zhu

Chen

Zhu

et al. 2016

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

ObjectiveThe study aims to know the effect of electroacupuncture (EA) in maintenance of the homeostasis of the neuroendocrine system in hepatectomy rats and the involvement of arginine vasopressin (AVP) signaling in hypothalamus after EA was observed.Materials and MethodsRats were randomly assigned to four groups, including the intact group, model group, sham‐EA group, and EA group. EA was given during the perioperative period at the Zusanli (ST36) and Sanyinjiao (SP6) points after hepatectomy. The serum adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels were detected via radioimmunoassay. The expression of AVP, arginine vasopressin receptor 1a (AVPR1a), arginine vasopressin receptor 1b (AVPR1b), and glucocorticoid receptor (GR) was detected by Western blot after surgery.ResultsCompared with the intact group, the ACTH and CORT levels in the serum of model group were increased, whereas the ACTH and CORT levels were decreased in the EA group compared with the model group. Moreover, AVP and AVPR1b protein levels in the pituitary gland were increased in the model group and decreased in the EA group. Further, a distinct increase in the AVP and AVPR1a protein levels was observed in the model group, whereas they were significantly decreased in the EA group. Blockade of AVPR1b by nelivaptan reduced the increase of ACTH and CORT. D [Leu4, Lys8] vasopressin can inhibit the effect of EA in rectification of the hyperactivity of the hypothalamic‐pituitary‐adrenal (HPA) axis.Conclusions EA application at ST36 and SP6 can ameliorate the hyperactivity of the HPA axis via AVP signaling during the perioperative period.

show abstract

“…At present, except inflammatory reactions, oxygen radical has also been known as playing an important role in the genesis and development of POCD (13,36). TAES can increase superoxide dismutase (SOD) level, inhibit malondialdehyde (MDA) gather and play a role to protect brain function.…”

Section: Probable Mechanism Of Acupoint Stimulationmentioning

confidence: 99%

“…TAES can increase superoxide dismutase (SOD) level, inhibit malondialdehyde (MDA) gather and play a role to protect brain function. SOD is a kind of antioxidative enzyme which can scavenge oxygen radicals, thereby blocking the lipid peroxidation chain reaction (36). MDA is a metabolic product of the peroxidation of unsaturated fatty acid in biofilm initiated by oxygen radicals.…”

Section: Probable Mechanism Of Acupoint Stimulationmentioning

confidence: 99%

The Role of Perioperative Acupoint Stimulation in the Prevention of Postoperative Cognitive Dysfunction

Yuan¹,

Yu²

2016

J Anesth Perioper Med

View full text Add to dashboard Cite

The effects of electroacupuncture treatment on the postoperative cognitive function in aged rats with acute myocardial ischemia–reperfusion

Cited by 42 publications

References 41 publications

Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

Arginine Vasopressin and Arginine Vasopressin Receptor 1b Involved in Electroacupuncture-Attenuated Hypothalamic-Pituitary-Adrenal Axis Hyperactivity in Hepatectomy Rats

The Role of Perioperative Acupoint Stimulation in the Prevention of Postoperative Cognitive Dysfunction

Contact Info

Product

Resources

About