Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models

Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines

“…According to previous reports about the anti-inflammatory effects of Panax ginseng [ [28] , [29] , [30] , [31] ], Panax ginseng contains various bioactive constituents such as ginsenosides. Tung et al [ 32 ] evaluated some of the compounds in ginseng that have anti-inflammatory effects and anti-oxidant activity.…”

Exploring Amygdala Structural Changes and Signaling Pathways in Postmortem Brains: Consequences of Long-Term Methamphetamine Addiction

“…Previous studies have highlighted the neuroprotective effects of factors such as CREB, BDNF, and Akt-1 in the CNS, promoting neuronal regeneration, survival, and growth (51). Impairment in CREB regulation has been linked to programmed cell death, ROS production, and neurodegeneration (52). In light of this, we conducted a comprehensive analysis of the potential signaling pathways, namely CREB/BDNF and Akt-1/GSK-3, that may be disrupted in the amygdala of individuals using METH.…”

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

“…58 The neuroprotective effect of ginsenosides may be related to the MAPK, PI3K/AKT, cyclin-dependent kinase 5, BDNF/ TrkB, protein kinase A/cAMP-response element binding protein (CREB), fibroblast growth factor 2 (FGF2)/AKT, NF-κB, nod-like receptor protein1, N-methyl-D-aspartate receptor 2B/ ERK (extracellular regulated protein kinase)/CREB/BDNF, notch, Wnt/β-catenin, toll-like receptor-3 (TLR3), and TLR4 signaling pathways. 45,59,60 Ginsenosides could improve various nervous system diseases (Table 1). For instance, ginsenoside Rg1 curtailed oxi- Food & Function Review dative stress, minimized neuro-inflammation and safeguarded neurons by regulating the GSK-3β/Wnt pathway, thereby improving cognitive impairment in Alzheimer's disease (AD).…”

“…The neuroprotective effect of ginsenosides may be related to the MAPK, PI3K/AKT, cyclin-dependent kinase 5, BDNF/TrkB, protein kinase A/cAMP-response element binding protein (CREB), fibroblast growth factor 2 (FGF2)/AKT, NF-κB, nod-like receptor protein1, N -methyl- d -aspartate receptor 2B/ERK (extracellular regulated protein kinase)/CREB/BDNF, notch, Wnt/β-catenin, toll-like receptor-3 (TLR3), and TLR4 signaling pathways. 45,59,60…”