Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines

Kim, Jisu; Zhu, Ying; Wang, Ruirui; Wang, Jianxin

doi:10.1016/j.jgr.2023.01.004

Cited by 18 publications

(11 citation statements)

References 52 publications

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“…The broccoli-derived EVs have been shown to prevent colitis by inducing tolerogenic dendritic cells (DCs) via the AMP-activated protein kinase (AMPK) pathway through their encapsulated sulforaphane . In contrast, tumeric-derived EVs exert their anticolitis effect by regulating the expression of inflammation-related genes, inactivating the NF-κB pathway, modulating the gut microbiota, and repairing the damaged intestinal epithelial barrier. , As a well-known dietary supplement and traditional medicine in Asia, ginseng-derived EVs also have various bioactive functions, including wound healing, colitis alleviation, and anticancer activities. Of note, Sundaram et al found that garlic-derived EVs could be taken up by microglial cells via the gut/brain axis .…”

Section: Biological Activities and Applications Of Different Pdevsmentioning

confidence: 99%

Plant-Derived Extracellular Vesicles: A New Revolutionization of Modern Healthy Diets and Biomedical Applications

Lo,

Wang,

et al. 2024

J. Agric. Food Chem.

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Plant-derived extracellular vesicles (PDEVs) have recently emerged as a promising area of research due to their potential health benefits and biomedical applications. Produced by various plant species, these EVs contain diverse bioactive molecules, including proteins, lipids, and nucleic acids. Increasing in vitro and in vivo studies have shown that PDEVs have inherent pharmacological activities that affect cellular processes, exerting anti-inflammatory, antioxidant, and anticancer activities, which can potentially contribute to disease therapy and improve human health. Additionally, PDEVs have shown potential as efficient and biocompatible drug delivery vehicles in treating various diseases. However, while PDEVs serve as a potential rising star in modern healthy diets and biomedical applications, further research is needed to address their underlying knowledge gaps, especially the lack of standardized protocols for their isolation, identification, and large-scale production. Furthermore, the safety and efficacy of PDEVs in clinical applications must be thoroughly evaluated. In this review, we concisely discuss current knowledge in the PDEV field, including their characteristics, biomedical applications, and isolation methods, to provide an overview of the current state of PDEV research. Finally, we discuss the challenges regarding the current and prospective issues for PDEVs. This review is expected to provide new insights into healthy diets and biomedical applications of vegetables and fruits, inspiring new advances in natural foodbased science and technology.

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Section: Biological Activities and Applications Of Different Pdevsmentioning

confidence: 99%

Plant-Derived Extracellular Vesicles: A New Revolutionization of Modern Healthy Diets and Biomedical Applications

Lo,

Wang,

et al. 2024

J. Agric. Food Chem.

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“…Grape-derived extracellular vesicles promote proliferation and differentiation of intestinal stem cells, facilitating intestinal epithelial regeneration and protecting mice from dextran sulfate sodium (DSS)-induced colitis ( 57 ). Ginseng-derived extracellular vesicles suppress the nuclear factor Kappa-Light-Chain-Enhancer of activated B cells (NF-κB) pathway, reduce inflammatory factor levels, and improve gut microbiota composition, effectively treating DSS-induced colitis in mouse models ( 69 , 70 ). Lemon-derived extracellular vesicles manipulate probiotics (C. diff) to inhibit Clostridioides difficile infection, a major cause of antibiotic-associated colitis ( 71 , 72 ).…”

Section: Plant-derived Extracellular Vesiclesmentioning

confidence: 99%

Applications of emerging extracellular vesicles technologies in the treatment of inflammatory diseases

Lou,

Luo,

Jiang

et al. 2024

Front. Immunol.

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The emerging extracellular vesicles technologies is an advanced therapeutic approach showing promising potential for addressing inflammatory diseases. These techniques have been proven to have positive effects on immune modulation and anti-inflammatory responses. With these advancements, a comprehensive review and update on the role of extracellular vesicles in inflammatory diseases have become timely. This review aims to summarize the research progress of extracellular vesicle technologies such as plant-derived extracellular vesicles, milk-derived extracellular vesicles, mesenchymal stem cell-derived extracellular vesicles, macrophage-derived extracellular vesicles, etc., in the treatment of inflammatory diseases. It elucidates their potential significance in regulating inflammation, promoting tissue repair, and treating diseases. The goal is to provide insights for future research in this field, fostering the application and development of extracellular vesicle technology in the treatment of inflammatory diseases.

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“…Take ginseng-derived PDVLNs for example: the composition of ginseng-derived PDVLNs was analyzed, and it was found that ginseng-derived PDVLNs mainly consist of phosphatidylcholines (PC), along with 98 miRNAs and 86 proteins similar to those of Panax ginseng [108] (Figure 3). Ginseng-derived PDVLNs have demonstrated high stability, specific targeting abilities, and effective anti-cancer properties in immune regulation; thus, they could be a potential therapeutic option for cancer [109].…”

Section: The Application Of Pdvlnsmentioning

confidence: 99%

“…phosphatidylcholines (PC), along with 98 miRNAs and 86 proteins similar to those of Panax ginseng [108] (Figure 3). Ginseng-derived PDVLNs have demonstrated high stability, specific targeting abilities, and effective anti-cancer properties in immune regulation; thus, they could be a potential therapeutic option for cancer [109].…”

Section: The Application Of Pdvlnsmentioning

confidence: 99%

Plant-Derived Vesicle-like Nanoparticles: The Next-Generation Drug Delivery Nanoplatforms

Wang,

Xin,

Zhou

et al. 2024

Pharmaceutics

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A wide variety of natural bioactive compounds derived from plants have demonstrated significant clinical relevance in the treatment of various diseases such as cancer, chronic disease, and inflammation. An increasing number of studies have surfaced that give credence to the potential of plant-derived vesicle-like nanoparticles (PDVLNs) as compelling candidates for a drug delivery system (DDS). PDVLNs are cost-effective production, non-toxicity and non-immunogenicity and fascinating bi-ocompatibility. In this review, we attempt to comprehensively review and consolidate the position of PDVLNs as next-generation drug delivery nanoplatforms. We aim to give a quick glance to readers of the current developments of PDVLNs, including their biogenesis, characteristic features, composition, administration routes, advantages, and application. Further, we discuss the advantages and limitations of PDVLNs. We expect that the role of PDVLNs in drug delivery will be significantly enhanced, thus positioning them as the next generation of therapeutic modalities in the foreseeable future.

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Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines

Cited by 18 publications

References 52 publications

Plant-Derived Extracellular Vesicles: A New Revolutionization of Modern Healthy Diets and Biomedical Applications

Plant-Derived Extracellular Vesicles: A New Revolutionization of Modern Healthy Diets and Biomedical Applications

Applications of emerging extracellular vesicles technologies in the treatment of inflammatory diseases

Plant-Derived Vesicle-like Nanoparticles: The Next-Generation Drug Delivery Nanoplatforms

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