Ginsenoside extract from ginseng extends lifespan and health span in <i>Caenorhabditis elegans</i>

Wang, Hui; Zhang, Shuai; Zhai, Lu; Sun, Liwei; Zhao, Daqing; Wang, Zeyu; Li, Xiangyan

doi:10.1039/d1fo00576f

Cited by 35 publications

(16 citation statements)

References 46 publications

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“…Rg1 and Re exhibited similar anti-aging effects as TGGR in Drosophila . Consistent with other studies, Rg1 and Re are the major components of Panax ginseng, which prolongs the lifespan of C. elegans ( Wang et al, 2021 ), and Rg1 prevents cognitive impairment and hippocampal senescence in a rat model of aging ( Zhou et al, 2020 ). In future studies, specific anti-aging effects of single saponins should be clarified, and synergistic studies of each saponin based on clear molecular mechanisms should be examined.…”

Section: Discussionsupporting

confidence: 89%

“…Therefore, ginsenosides have the potential to be used as an alternative natural medicine for anti-aging and life-prolonging effects. A recent study reported that total ginsenoside extract can prolong the lifespan and healthy lifespan of Caenorhabditis elegans ( C. elegans ) by activating anti-oxidation signaling pathways ( Wang et al, 2021 ). However, the use of ginsenoside extract for delaying human aging, its anti-aging activities, optimal dosage and means of administration in different species need further investigation, and its multi-target mechanism of action needs to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Zhao

Liu

Zhang

et al. 2022

Front. Aging Neurosci.

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In an increasingly aged global population, achieving healthy life expectancy through natural and safe drug interventions is highly desirable. Here we show that total ginsenosides (TGGR), the main active components in the traditional Chinese medicine, ginseng, promote longevity across species. In Drosophila, an intriguing effect of TGGR on lifespan was the relatively narrow treatment window to elicit long-term benefits. TGGR administration during early adulthood, and especially during midlife, was sufficient to extend lifespan in both sexes. TGGR did not increase lifespan by reducing food intake or reproductive capacity; rather, TGGR increased the fertility of male Drosophila. TGGR augmented healthspan readouts associated with youth and with healthy aging, such as motility, intestinal barrier integrity, and biorhythm homeostasis. TGGR treatment also improved some types of stress resistance in both sexes, including increased tolerance to starvation and oxidation, and shifting “aged” gene expression patterns toward “healthy” patterns seen in the young. Gene expression, pharmacological and genetic epistatic analyses demonstrated that TGGR effects require normal expression of genes involved in insulin, TOR and MAPK signaling. The positive effects of TGGR on both healthspan and lifespan, coupled with its mechanism of action via evolutionarily conserved signaling pathways, demonstrate it to be a promising anti-aging drug.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Zhao

Liu

Zhang

et al. 2022

Front. Aging Neurosci.

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“…The activation of the Nrf2 signaling pathway plays an important role in the antioxidant process ( 29 ). The antioxidant activity is closely related with the traditional use of Baizhu for improving longevity ( 30 ).…”

Section: Resultsmentioning

confidence: 99%

Sesquiterpene Lactams and Lactones With Antioxidant Potentials From Atractylodes macrocephala Discovered by Molecular Networking Strategy

Wang

Zhao

et al. 2022

Front. Nutr.

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Atractylodes macrocephala rhizome (called Bái-zhú in China) has a long history as a functional food and herbal medicine in East Asia, especially China. Sesquiterpenoids are one of the main active compounds of Atractylodes macrocephala rhizome. This study aimed to explore the unknown sesquiterpenoids of A. macrocephala rhizome using a molecular networking strategy. Two new nitrogen-containing sesquiterpenoids, atractylenolactam A (1) and atractylenolactam B (2), and 2 new sesquiterpene lactones, 8-methoxy-atractylenolide V (6) and 15-acetoxyl atractylenolide III (7), along with 12 known analogs (3-5 and 8-16) were discovered and isolated. All the structures were assigned based on detailed spectroscopic analyses. The absolute configurations of 1, 2, 6, and 7 were established by time-dependent density functional theory ECD (TDDFT-ECD) calculations. All these compounds had different degrees of concentration-dependent activating effects on nuclear-factor-E2-related factor-2 (Nrf2).

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“…A stepwise gradient elution method was employed using solvent A (water) and solvent B (acetonitrile) that were maintained at 30°C. The flow rate was 1 mL/min and sample injection volume was 10 µL ( 32 , 33 ).…”

Section: Methodsmentioning

confidence: 99%

Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway

Liu

et al. 2022

Front. Endocrinol.

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Aging ovaries caused diminished fertility and depleted steroid hormone level. Ginsenosides, the active ingredient in ginseng, had estrogen-like hormonal effects. Although ginsenosides were well known for their ability to alleviate many age-related degenerative diseases, the effect of ginsenosides on the decline in reproductive capability caused by aging, as well as the mechanism, are unknown. We found that ginsenosides improved the quantity and quality of the offspring, prolonged life and restored muscle ability in aged female Drosophila. In addition, ginsenosides inhibited ovarian atrophy and maintained steroid hormone 20-Hydroxyecdysone (20E) and juvenile-preserving hormone (JH)) levels. Ginsenosides activated ecdysteroid receptor (ECR) and increased the expression of the early transcription genes E74 and Broad (Br), which triggered steroid signaling pathway. Meanwhile, ginsenosides promoted JH biosynthesis by increasing the expression of Hydroxyl-methylglutaryl-CoA reductase (HMGR) and juvenile hormone acid O-methyltransferase (JHAMT). Subsequently, JH was bound to Methoprene Tolerant (Met) and activated the transcription of the responsive gene Kruppel Homolog 1 (Kr-h1), which coordinated with 20E signaling to promote the reproduction of aged female Drosophila. The reproductive capacity and steroid hormone levels were not improved and the steroid signaling pathway was not activated in ginsenoside-treated ECR knockout Drosophila. This suggested that ginsenosides played a role dependent on targeted ECR. Furthermore, 17 kinds of ginsenoside monomers were identified from the total ginsenosides. Among them, Rg1, Re and Rb1 improved the reproductive capacity and steroid hormone levels of aged female Drosophila, which has similar effects to the total ginsenoside. These results indicated that ginsenosides could enhance the reproductive capacity of aged female Drosophila by activating steroid signals dependent on nuclear receptor ECR. In addition, ginsenoside monomers Rg1, Rb1 and Re are the main active components of total ginsenosides to improve reproductive ability. This will provide strong evidence that ginsenosides had the potential to alleviate age-induced reproductive degradation.

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Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans

Abstract: Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans through activating NRF2/SKN-1, SIRT1/SIR 2.1, and FOXO/DAF-16 signaling pathways.

Cited by 35 publications

References 46 publications

Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Sesquiterpene Lactams and Lactones With Antioxidant Potentials From Atractylodes macrocephala Discovered by Molecular Networking Strategy

Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway

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