Ginkgolide B produced endophytic fungus (Fusarium oxysporum) isolated from Ginkgo biloba

Cui, Yuna; Yi, Danhui; Bai, Xiufeng; Sun, Baoshan; Zhao, Yanan; Zhang, Yixuan

doi:10.1016/j.fitote.2012.04.009

Cited by 112 publications

(48 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ginkgolides are diterpenoid lactones known as secondary metabolites of G. biloba which are considered, particularly ginkgolide B, as prospect drugs based on documented antagonistic effects against the platelet-activating factor involved in a number of inflammatory disorders. Ginkgolides A-C and the related compound bilobalide (Figure 1) have been found as fermentation products of an endophytic strain of Fusarium oxysporum recovered from root bark of this living fossil tree [106].…”

Section: Other Terpenoidsmentioning

confidence: 99%

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

View full text Add to dashboard Cite

Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

show abstract

Section: Other Terpenoidsmentioning

confidence: 99%

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

View full text Add to dashboard Cite

show abstract

“…Fusarium sp. has a wide occurrence as endophyte in many plant species including Drepanocarpus lunatus (Liu et al 2016), Axonopus compressus (Zakaria and Ning 2013), Nothapodytes foetida (Musavi and Balakrishnan 2013), Dioscorea zingiberensis (Li et al 2014), Solanum lycopersicum (Aimé et al 2013), Juniperus recurva, Catharanthus roseus (Kumar et al 2013), Ginkgo biloba (Cui et al 2012), etc. Colletotrichum sp.…”

Section: Discussionmentioning

confidence: 99%

“…Endophytic F. oxysporum is also reported to produce its corresponding host metabolites such as podophyllotoxin, taxol (Elavarasi et al 2012), ginkgolide B (Cui et al 2012), vincristine, and vinblastin (Kumar et al 2013), which thus indicates its close association with different hosts.…”

Section: Discussionmentioning

confidence: 99%

Metabolite analysis of endophytic fungi from cultivars of Zingiber officinale Rosc. identifies myriad of bioactive compounds including tyrosol

Anisha

Radhakrishnan

2017

3 Biotech

View full text Add to dashboard Cite

Endophytic fungi associated with rhizomes of four cultivars of Zingiber officinale were identified by molecular and morphological methods and evaluated for their activity against soft rot pathogen Pythium myriotylum and clinical pathogens. The volatile bioactive metabolites produced by these isolates were identified by GC-MS analysis of the fungal crude extracts. Understanding of the metabolites produced by endophytes is also important in the context of raw consumption of ginger as medicine and spice. A total of fifteen isolates were identified from the four varieties studied. The various genera identified were Acremonium sp., Gliocladiopsis sp., Fusarium sp., Colletotrichum sp., Aspergillus sp., Phlebia sp., Earliella sp., and Pseudolagarobasidium sp. The endophytic community was unique to each variety, which could be due to the varying host genotype. Fungi from phylum Basidiomycota were identified for the first time from ginger. Seven isolates showed activity against Pythium, while only two showed antibacterial activity. The bioactive metabolites identified in the fungal crude extracts include tyrosol, benzene acetic acid, ergone, dehydromevalonic lactone, N-aminopyrrolidine, and many bioactive fatty acids and their derivatives which included linoleic acid, oleic acid, myristic acid, nhexadecanoic acid, palmitic acid methyl ester, and methyl linoleate. The presence of these varying bioactive endophytic fungi may be one of the reasons for the differences in the performance of the different ginger varieties.

show abstract

“…Screening of 27 endophytic fungal strains isolated from the bark of G. biloba trees revealed that only one isolate F. oxysporum SY0056, was capable of producing Ginkgolide B (Cui et al, 2012). The search for bilobalide -producing endophytic fungi was far more copious; a total of 57 fungal strains were isolated from stem, root, leaf, and bark of the plant G. biloba and their extracts were evaluated for the presence of bilobalide.…”

Section: Ginkgo Biloba L (Ginkoaceae)mentioning

confidence: 99%

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Venieraki

Dimou

Katinakis

2017

Hellenic Plant Protection Journal

View full text Add to dashboard Cite

SummaryMedicinal plants have been used for thousands of years in folk medicines and still are used for their health benefi ts. In our days medicinal plants are exploited for the isolation of plant-derived drugs as they are very eff ective and have relatively less or no side eff ects. However, the natural resources of medicinal plants are gradually exhausted and access to plant bioactive compounds is challenged by the low levels at which these products accumulate in native medicinal plants. For instance, to meet the market demands of 3 Kg per year of vinca alkaloids, powerful plant-derived anticancer drugs, 1.5x106 Kg dry leaves are required. In this regard, this review aims to highlight the fact that endophytic fungi residing in medicinal plants are capable to biosynthesize pharmacologically active secondary metabolites similar or identical to those produced by their host medicinal plant. Furthermore, the evolutionary origin of the genes involved in these metabolic pathways as well as the approaches designed to enhance the production of these metabolites by the isolated endophytic fungi are also discussed.Additional key words: metabolites from endophytic bacteria and actinomycetes, chemical ecology present in virtually all organs of a given plant host, and some are seed borne. Endophytes often confer considerable benefi ts to the host plant they inhabit, since they can promote the growth of host plants, enhance resistance to biotic and abiotic stresses (Rodriguez et al., 2009; Hardoim et al., 2015), and accumulate bioactive secondary metabolites (Kusari et al., 2012). The ecological role of secondary metabolites produced by endophytes is not clear. However, recent studies have shown that these metabolites are involved in deterrence of herbivory (Pannaccione et al., 2014), protection against fungal (Soliman et al., 2015) or bacterial pathogens (Mousa et al., 2017) and amelioration of plant abiotic stress (Hamayum et al., 2016). Bioactive secondary metabolites derived from medicinal plants are gradually decreasing -Alternative approaches for their productionMedicinal plants, as a rich source of nat-

show abstract

Ginkgolide B produced endophytic fungus (Fusarium oxysporum) isolated from Ginkgo biloba

Cited by 112 publications

References 22 publications

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Metabolite analysis of endophytic fungi from cultivars of Zingiber officinale Rosc. identifies myriad of bioactive compounds including tyrosol

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Contact Info

Product

Resources

About