Gingival overgrowth induced by nifedipine: Gingiva and drugs

Pejčić, Ana; Kesić, Ljiljana; Živković, Vesna; Obradoviç, Radmila; Petrović, Milica S.; Mirković, Dimitrije

doi:10.5937/asn1164104p

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…To eliminate disease-associated pathogens in PD and ameliorate clinical condition, empiric antibiotic treatments are often used in combination with mechanical debridement [ 43 ]. Various antimicrobial agents are either administered orally or incorporated in chemical agents such as mouthwashes and toothpastes to inhibit plaque-causing bacteria.…”

Section: Treatment Options Available For Treating Bacterial Infection...mentioning

confidence: 99%

Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems

et al. 2023

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With the advancement of biomedical research into antimicrobial treatments for various diseases, the source and delivery of antibiotics have attracted attention. In periodontal diseases, antibiotics are integral in positive treatment outcomes; however, the use of antibiotics is with caution as the potential for the emergence of resistant strains is of concern. Over the years, conventional routes of drug administration have been proven to be effective for the treatment of PD, yet the problem of antibiotic resistance to conventional therapies continues to remain a setback in future treatments. Hydrogels fabricated from natural and synthetic polymers have been extensively applied in biomedical sciences for the delivery of potent biological compounds. These polymeric materials either have intrinsic antibacterial properties or serve as good carriers for the delivery of antibacterial agents. The biocompatibility, low toxicity and biodegradability of some hydrogels have favoured their consideration as prospective carriers for antibacterial drug delivery in PD. This article reviews PD and its antibiotic treatment options, the role of bacteria in PD and the potential of hydrogels as antibacterial agents and for antibiotic drug delivery in PD. Finally, potential challenges and future directions of hydrogels for use in PD treatment and diagnosis are also highlighted.

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Section: Treatment Options Available For Treating Bacterial Infection...mentioning

confidence: 99%

Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems

et al. 2023

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“…After the surgery, patients can adequately maintain oral hygiene, which is necessary to prevent recidivism (35,62). The use of carbon dioxide laser is suitable in these cases due to accuracy in cutting, better hemostatic and antimicrobial effect, minimal edema and postoperative pain, as well as dry field and improved visibility (4,5,25,35,68,69).…”

Section: Treatmentmentioning

confidence: 99%

“…The most significant risk factors for recurrence are younger age, gingival inflammation and irregular visits to the dentist (4,5,69,70). It is also concluded that regular use of chlorhexidine oral rinse (0.12%) after surgery helps prevent reappearance by inhibiting plaque accumulation and gingival inflammation (4,68,71).…”

Section: Treatmentmentioning

confidence: 99%

Gingival Enlargement Caused by Calcium Channel Blockers

Desnica

Vujović

Stevanović

et al. 2022

Experimental and Applied Biomedical Research (EABR)

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Calcium channel blockers, a group of drugs widely used in the treatment of cardiovascular patients, although effective, often cause gingival enlargement, a side effect that is rarely recognized in clinical practice and is not given sufficient importance. Gingival enlargement caused by calcium channel blockers can be localized or generalized, mild or severe. It can negatively affect patients’ appearance, mastication, and speech, thus considerably reducing the quality of life of patients. Risk factors and pathogenesis of this side effect have been the subject of many studies but are still unknown, making this condition a major therapeutic challenge, especially if the cessation of the offending drug is not possible. This study aimed to review the etiology, potential risk factors, pathogenesis, clinical features, and therapy possibilities for gingival enlargement caused by calcium channel blockers.

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“…Within the calcium channel blocker family, nifedipine, diltiazem, verapamil, and amlodipine are among the most commonly reported causative agents [39,40,41]. The gingival overgrowth is usually related to the dose of the drugs, the duration of therapy, the serum concentration, and the presence of dental plaque [42,43]. Clinically, both marginal gingiva and interdental papilla appear enlarged and firm, with a surface that may be smooth, stippled, or lobulated.…”

Section: Drug Induced Gingival Enlargementmentioning

confidence: 99%