Gingival Metastasis as First Sign of an Undifferentiated Carcinoma of the Lung

Peris, Ketty; Cerroni, Lorenzo; Paoloni, Mauro; Margiotta, Valerio; Chimenti, Sergio

doi:10.1111/j.1524-4725.1994.tb02626.x

Cited by 17 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 This case also highlights the importance of biopsy procedures to unravel the diagnosis of an apparent unpretentious case. Other authors also reported on oral cavity metastatic masses as a primary sign of a primary malignancy, as examples, Peris et al, 22 in 1994 diagnosed a gingival mass as the first evidence of a primary lung undifferentiated carcinoma; Llannes et al, 23 reported 2 cases of oral neoplasms that represented the first manifestation of hepatocellular carcinoma, similar to case 7; Patel et al 24 diagnosed a gingival mass as the first sign of a renal cell carcinoma and Park et al 25 have biopsied a gingival mass representative of an undifferentiated sarcomatoid carcinoma of the lung.…”

Section: Discussionmentioning

confidence: 95%

Metastasis to the Oral Cavity: Report of 12 Cases

Lourenço

Florezi

Smitter

et al. 2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Oral cavity is not a common route for metastatic dissemination; metastasis to the oral region may affect soft tissues and jawbones, accounting for approximately 1% of all oral malignant neoplasms. The diagnosis of metastatic lesions to the oral cavity is usually challenging to clinicians and pathologists because of their complexity and rarity. We present a series of 12 metastatic neoplasms to the oral cavity that were detected previously or after the diagnosis of the primary tumor. All tumors were of epithelial origin with primary sites in the esophagus (2 cases), colon (2 cases), bladder, lungs, liver, larynx, skin, uterus, prostate, and adrenal gland, each with one case. The commonest site of the metastatic masses in the oral cavity was the gingiva, frequently presented as a vegetating, friable mass. The clinical examination and histopathologic analysis of the lesions were central to establishing the final diagnosis of the tumors. Metastatic masses to the oral cavity should always be considered as differential diagnosis of benign-looking lesions, especially in patients with previous history of a malignant disease. Biopsy is mandatory to establish an accurate diagnosis.

show abstract

Section: Discussionmentioning

confidence: 95%

Metastasis to the Oral Cavity: Report of 12 Cases

Lourenço

Florezi

Smitter

et al. 2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…From 1964 to 2013, 28 cases of gingival metastasis from the primary lung carcinoma were detected according to English literature. There were 9 adenocarcinoma 1,7-14 (AC), 1 poorly differentiated adenocarcinoma 15 (pdAC), 3 squamous cell carcinoma [16][17][18] (SC), 2 small cell carcinoma 17,19 (SCC), 1 poorly differentiated squamous cell carcinoma 20 (pdSC), 2 large cell carcinoma 14,21 (LCC), 7 undifferentiated carcinoma 17,[22][23][24][25][26][27] (UDC), 1 leiomyosarcoma 18 (LS), 1 malignant fibrous histiocytoma 28 (MFH) and 1 epithelial cell carcinoma 29 (ECC) in all of these cases. Maxillary (14 cases) and mandibular (14 cases) gingiva were affected equally according to review of the literature.…”

Section: Discussionmentioning

confidence: 99%

Gi̇ngi̇val Metastasi̇s From the Squamous Cell Carci̇noma of the Lung: A Case Report and Revi̇ew of the Li̇terature

Üngör¹,

Memiş²,

Günhan³

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

View full text Add to dashboard Cite

Metastasis of a lung carcinoma to the gingiva is very uncommon, but it must be considered as a first sign of the primary tumour. Most reported cases involve the jaws rather than the soft tissues. The clinical presentation of gingival metastasis include: rapid growth, pain, swelling, chewing dysfunction, trismus, haemorrhagic tendency, paresthesia, dysphagia and pathological fracture. However, the final diagnosis is based on the histopathological evaluation. In this case report, a 59 years-old male patient with a gingival metastasis from lung squamous cell carcinoma was presented. Also, the review of 23 case reports of the oral metastasis from lung carcinoma in English literature were demonstrated.

show abstract

“…In the case of metastatic tumors for which the primary tumor is unknown, we advocate performing a Pet-scan if the results of the Body-Scan are negative. The treatment will depend on many factors; however in cases of metastasis to soft tissue, complete excision is advisable regardless of the degree of dissemination (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). If it involves the bone and is the only location where it is seated, surgical resection is advised if possible, but if the extension study reveals evidence of the spread of the primary tumor or that the metastasis cannot be resected, palliative treatment is recommended.…”

Section: Discussionmentioning

confidence: 99%