Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion

Santos, Jéssica Luana Dos; Macedo, Rander Moreira; Almeida, Luciana Yamamoto; Silva, Rodrigo Neves; Ribeiro‐Silva, Alfredo; León, Jorge Esquiche

doi:10.1111/cup.13278

Cited by 5 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[11][12][13] Intraoral pigmented lesions are a common condition, with exogenous or endogenous origin. 2,[14][15][16] Considering its exogenous origin, AT is the most common, followed by graphite tattoo and drug-related pigmentation. AT is often discovered during routine dental treatment, and radiography can show metallic particles, such as observed in the current case.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Elastofibromatous changes in giant cell fibroma and amalgam tattoo: Unusual findings in common oral lesions

Silva,

Martins,

Reyes

et al. 2024

J Cutan Pathol

Self Cite

View full text Add to dashboard Cite

Several cases of elastofibromatous lesion affecting the oral mucosa have been reported. Clinically, these lesions may appear as small exophytic lesions or less often as white lesions. Therefore, fibrous hyperplasia and leukoplakia are not uncommonly considered in clinical differential diagnosis. Microscopically, elastic and fibrous connective tissue deposition is seen. Rarely, elastofibromatous changes can be detected when assessing intraoral lesions, including cysts, salivary gland neoplasms, and epithelial dysplasia. Here we report two oral lesions showing elastofibromatous changes, expanding their clinicopathological spectrum. The first case was a 46‐year‐old man with a history of asymptomatic nodular lesion on the palate 1 year ago, diagnosed as giant cell fibroma with elastofibromatous changes. The second case was a 79‐year‐old woman who presented a pigmented and mildly symptomatic lesion on the mandibular alveolar mucosa several months ago, diagnosed as amalgam tattoo associated with elastofibromatous changes.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Intraoral pigmented lesions are a common condition, with exogenous or endogenous origin 2,14–16 . Considering its exogenous origin, AT is the most common, followed by graphite tattoo and drug‐related pigmentation.…”

Section: Discussionmentioning

confidence: 99%

Elastofibromatous changes in giant cell fibroma and amalgam tattoo: Unusual findings in common oral lesions

Silva,

Martins,

Reyes

et al. 2024

J Cutan Pathol

Self Cite

View full text Add to dashboard Cite

show abstract

“…The phenomenon of junctional nesting or pseudonesting in the setting of microscopic lichenoid/ interface changes, although infrequently and regardless of the terms used, has been previously reported. 1,3,13,[15][16][17][18] The current practice is to categorize this rare phenomenon into three different microscopic groups: "pseudomelanocytic nests" that are composed of macrophages, keratinocytes, melanocytic debris without melanocytes; "melanocytic pseudonests" or "mixed nests" that are composed of keratinocytes, inflammatory cells and melanocytes; and "true melanocytic nests" made exclusively of melanocytes. Our case belongs to the latter group as junctional nested cells stained positively for S-100, Melan-A, HMB-45, and SOX-10 and negatively for CD3 and CD68.…”

Section: Discussionmentioning

confidence: 99%

“…Our case is peculiar for the blaschkoid disposition of the pigmentary lesions and for the discovery of junctional “true melanocytic nests” on histopathologic grounds. The phenomenon of junctional nesting or pseudonesting in the setting of microscopic lichenoid/interface changes, although infrequently and regardless of the terms used, has been previously reported 1,3,13,15–18 . The current practice is to categorize this rare phenomenon into three different microscopic groups: “pseudomelanocytic nests” that are composed of macrophages, keratinocytes, melanocytic debris without melanocytes; “melanocytic pseudonests” or “mixed nests” that are composed of keratinocytes, inflammatory cells and melanocytes; and “true melanocytic nests” made exclusively of melanocytes.…”

Section: Discussionmentioning

confidence: 99%

Blaschkoid melanotic cutaneous lupus erythematosus with “melanocytic nests”

Bigotto,

Podo‐Brunetti,

Stabile

et al. 2023

J Cutan Pathol

View full text Add to dashboard Cite

Melanotic cutaneous lupus erythematosus (LE) is a newly described clinical variant of chronic cutaneous LE, presenting with localized or diffuse brownish or grayish macular and reticulated pigmentation in the absence of erythema, scaling, atrophy, scarring, or telangiectasia. The diagnosis is based upon histopathology, which demonstrates the characteristic features of LE with an interface vacuolar dermatitis with melanophages, and a superficial and deep, perivascular and periadnexal lymphocytic infiltrate with mucin deposition. Herein, we describe a case of a 61‐year‐old White male presenting with melanotic cutaneous LE with a blaschkoid distribution on his face in which the histopathological phenomenon of “true melanocytic nests” in the setting of a lichenoid pattern was seen. We want to highlight how nests of cellular aggregates at the dermoepidermal junction labeling with melanocytic markers may occur in the setting of an interface tissue reaction. This benign reactional pattern may mimic atypical melanocytic proliferations, especially on sun‐damaged skin. Clinicopathological correlation and careful microscopic examination using a panel of multiple melanocytic markers is crucial for making an accurate final diagnosis. All the cases of melanotic cutaneous LE reported in the literature are also reviewed.

show abstract

“…In fact, we have reported one OM case showing association with pseudomelanocytic nests. [ 7 ] The current case was an Afro-Brazilian descendent male patient, in whom the possibility of smoker's melanosis, post-inflammatory pigmentation or melanoma, were initially considered in the clinical differential diagnosis. Although most OM cases are asymptomatic, some are associated with pain, burning, and pruritus,[ 2 ] such as observed in the current case.…”

Section: Discussionmentioning

confidence: 99%

Melanoacanthoma, Plasma Cell Cheilitis and Langerhans Cell Hyperplasia on the Lower Lip: An Unusual Association and Immunohistochemical Analysis

et al. 2022

View full text Add to dashboard Cite

Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion

Cited by 5 publications

References 5 publications

Elastofibromatous changes in giant cell fibroma and amalgam tattoo: Unusual findings in common oral lesions

Elastofibromatous changes in giant cell fibroma and amalgam tattoo: Unusual findings in common oral lesions

Blaschkoid melanotic cutaneous lupus erythematosus with “melanocytic nests”

Melanoacanthoma, Plasma Cell Cheilitis and Langerhans Cell Hyperplasia on the Lower Lip: An Unusual Association and Immunohistochemical Analysis

Contact Info

Product

Resources

About