Gingival hyperplasia in rats induced by oxodipine ‐ a calcium channel blocker

Nyska, Abraham; Waner, Trevor; Pirak, M.; Galiano, Alvaro; Zlotogorski, Abraham

doi:10.1111/j.1600-0765.1990.tb00893.x

Cited by 30 publications

(10 citation statements)

References 13 publications

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“…We must highlight the great number of calcium antagonists, apart from nifedipine, that are being studied and that may have an effect on the gingiva, such as verapamil (Pernu et ai. J989), nitrendipine (Brown et al 1990), felodipine (Lombardi et al 1991), oxodipine in rats (Nyska et al 1990). All of them have different chemical and pharmacological characteristics from those found in nifedipine.…”

Section: Discussionmentioning

confidence: 99%

Clinical assessment of gingival hyperplasia in patients treated with nifedipine

Bullón¹,

Machuca²,

Martinez-Sahuquillo³

et al. 1994

J Clinic Periodontology

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Gingival hyperplasia caused by the use of nifedipine has been extensively reported. In this paper, the gingiva of 18 patients suffering from cardiopathy and treated with nifedipine were compared with those of 10 patients with cardiac disorders who had not been treated with calcium antagonists and with a no-treatment group of 12 patients. Nifedipine produced gingival hyperplasia, although patients who had not been treated with calcium antagonists also had mild hyperplasia. Hyperplasia first appeared in the interproximal areas, an observation which may be important for early detection. There was a direct correlation between the degree of hyperplasia and the bacterial plaque score. When we studied the influence of administration time and dose of nifedipine with the degree of hyperplasia, no statistically significant differences were found.

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Section: Discussionmentioning

confidence: 99%

Clinical assessment of gingival hyperplasia in patients treated with nifedipine

Bullón¹,

Machuca²,

Martinez-Sahuquillo³

et al. 1994

J Clinic Periodontology

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“…However, the features of cyclosporin A-induced gingival overgrowth were somewhat different from those induced by nifedipine or phenytoin, i.e., the collagenous component was more redundant in the cyclosporin A-induced gingival overgrowth than in that due to nifedipine or phenytoin ( 13) in rats and dogs (9). It has been reported that oxodipineinduced gingival overgrowth involved bulk enlargement due to fibroblastic proliferation without marked inflammatory cell infiltration in rats (15), or the lamina propria of the hyperplastic gingiva with fibroblastic and capillary proliferation covered by gingival epithelium with elongated rete pegs, acanthosis and parakeratosis in dogs (25). However, these histological changes were not observed in the gingival overgrowth induced by nifedipine in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a recent study by Nyska et a!. ( 15) showed for the first time that oxodipine, another dihydropyridine, induced gingival hyperplastic changes in rats without any inflammatory components in the gingiva, although the details still remain unclear. No study has yet investigated whether nifedipine like oxodipine induces gingival overgrowth in rats or how gingival inflammation and I or dental plaque is involved in its development.…”

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confidence: 99%

Nifedipine‐induced gingival overgrowth in the presence or absence of gingival inflammation in rats

Morisaki

Kato²,

Jp³

et al. 1993

J of Periodontal Research

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One adverse effect of nifedipine, a long‐acting vasodilator, is gingival overgrowth. Preexisting gingival inflammation and/or dental plaque has been suggested to be responsible for the progression of this side effect, but the precise mechanism is uncertain because of a lack of suitable animal models. A study was therefore done to establish an experimental model of gingival overgrowth in rats and to investigate the possible involvement of gingival inflammation and/or dental plaque in its development. Specific pathogen‐free Fischer rats (male, 14 days old) were used . Gingival inflammation and dental plaque accumulation were induced by infection with Streptococccus mutans MT8148R. The nifedipine‐treated rats (experimental group) were fed a caries‐inducing diet contai ning nifedipine either with or without infection, while the nifedipine‐untreated rats (control group) were fed the same diet, similarly with or with out the infection. Marked gingival overgrowth was induced in the mandibular molar region of nifedipine‐treated rats regardless of S. mutans infection, although the infection resulted in a further increase in the degree of gingival overgrowth. Histological examination of the gingival overgrowth revealed the presence of redundant subepithelial connective tissue in the treated rats, and inflammatory cell infiltration was apparent only in the tissue of the S. mutans‐infected rats regardless of the nifedipine administration. These findings suggest that nifedipine induces gingival overgrowth in rats either in the presence or absence of gingival inflammatio n and/or dental plaque, although these factors can augment the effect of the drug. Our experimental system seems to be a useful model for studying the mechanism of this side effect.

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“…Among the other drugs capable to induce a gingival overgrowth, there are some calciutn ion blockers as described in humans (28)(29)(30)(31)(32)(33)(34)(35)(36)(37), dogs (38,39), and rats (40). The most investigated is nifedipine (33)(34)(35)(36)(37), It has been widely used since 1977 for the treatment and prophylaxis of aeute and chronic coronary insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Felodipine‐induced gingival hyperplasia: a clinical and histologic study

Lombardi

Fiore-Donno

Belser

et al. 1991

J Oral Pathology Medicine

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This paper reports, for the first time, gingival hyperplasia in a patient treated with felodipine, a drug which belongs to the group of calcium ion antagonists. The observed gingival overgrowth was most significant in the area of interdental papillae of the anterior region of the mouth. The described hyperplastic tissue was characterized by a firm and pale appearance, with a normally stippled pattern. Histopathologically, a conspicuous increase of fibrous connective tissue, as well as an inflammatory infiltrate and hyperplasia of the overlying epithelium were observed. Consequently, the present observation adds another drug to the list of substances capable to induce gingival hyperplasia.

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Gingival hyperplasia in rats induced by oxodipine ‐ a calcium channel blocker

Cited by 30 publications

References 13 publications

Clinical assessment of gingival hyperplasia in patients treated with nifedipine

Clinical assessment of gingival hyperplasia in patients treated with nifedipine

Nifedipine‐induced gingival overgrowth in the presence or absence of gingival inflammation in rats

Felodipine‐induced gingival hyperplasia: a clinical and histologic study

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