Gingival Crevicular Fluid and Plasma Acute‐Phase Cytokine Levels in Different Periodontal Diseases

Abstract

Based on the present data, elevated IL-1β, IL-6, and IL-11 GCF levels, but not plasma levels, are suggested as reliable inflammatory biomarkers in periodontal diseases. Decreased LIF levels in diseased groups might reflect the possible beneficial effects of LIF in the modulation of inflammatory response in gingiva.

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

“…The authors explained this situation by affirming that IL-6 acts both as pro-and anti-inflammatory cytokine at the same time. Furthermore, similar to our results, Becerik et al 10 demonstrated that in GAgP group, GCF IL-6 cytokine level was higher than in the control group and plasma levels of IL-1beta and IL-6 were similar among GAgP, CP and gingivitis patients,and controls. Also, in this study, serum IL-6 level decreased after non-surgical periodontal therapy, but the difference was not significant.…”

“…9 A recent study reported that chronic periodontitis(CP) and generalized aggressive periodontitis (GAgP) patients had significantly higher GCF IL-6 levels in comparison with the healthy subjects. 10 Single nucleotide polymorphisms(SNPs) in the promoter region of IL-6 gene at positions -174G/C(rs 1800795), -572C/G(rs 1800796) and -597G/A(rs 1800797) have been described. First, Trevilatto et al reported an association between IL-6(-174) gene polymorphism and CP in the Caucasian race.…”

Salivary Biomarker Analysis Complementing Regular Clinical Examination

“…A very high correlation rate was also found between salivary K and P. This observation may gain support from the study published by Koregol and colleagues, who reported that the concentrations of K in the gingival crevicular fluid significantly correlated with the gingival index, and pocket-depth measurements reflect the clinical status of gingival and periodontal tissues [18]. Our study did not measure immunological factors in gingival crevicular fluid (GCF); however, a recent study showed that patients with gingivitis and chronic periodontitis had significantly higher IL-1b, IL-6 and IL-11 levels in GCF when compared with a healthy group [19]. Furthermore, Erdemir and Erdemir found that a positive correlation between the level of P and the percentage of bleeding on probing was found in cigarettesmoking patients diagnosed with chronic periodontitis who also had a higher plaque index [20].…”

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

“…Firstly, periodontitis may aggravate RA since periodontitis is accompanied by higher CRP levels [42][43][44][45][46] . The elevation of inflammatory cytokines (such as IL-1, IL-6) that are locally induced by periodontitis 47 is thought to induce systemic inflammation by increasing serum CRP levels and thus to contribute to an increased systemic inflammation in RA 48 . Secondly, RA may aggravate periodontitis.…”