Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats

Análise Sistemática Da Produção Científica Do Zingiber Officinale Roscoe Após a Criação Da Relação Nacional De Plantas Medicinais De Interesse Ao Sistema Único De Saúde

“…(25) . Referentes aos 19 estudos restantes foram abordadas as seguintes propriedades terapêuticas com pesquisas envolvendo o gengibre: tratamento da náusea induzida por quimioterapia (26) , função para absorção de Ferro, Zinco e Cálcio (27) , analgésico (28) , antidependência contra o uso crônico da morfina (29) , anti-inflamatório (30) , antimicrobiano (31) , combate à ação da artrite reumatoide (32) , aumento da proteólise muscular em patos (33) , tratamento do câncer de mama (14) , citoprotetor (15) , combate ao vírus sincicial respiratório humano (VSR) (34) , combate a sintomas da Doença de Alzheimer (35) , tratamento da fibrose hepática (36) , proteção contra a genotoxicidade (37) , inibição da enzima Angiotensina I (38) , inibição da motilidade do cólon (39) , atenuação da isquemia cerebral (40) , redução da nefrotoxicidade (41) e neuroprotetor (42) , as quais tiveram um estudo cada publicadas durante o período de análise.…”

Salvia officinalis L. attenuates morphine analgesic tolerance and dependence in rats: possible analgesic and sedative mechanisms

“…Veh + Sal + Sal, control group; Veh + Mor + Nal, morphine-dependent naloxone-treated group; SO + Mor + Nal, morphine-dependent groups that received SO at doses of 400, 600 and 800 mg/kg before naloxone injection; Veh + Sal + Nal, a group that received naloxone alone; ordinate, mean ± SEM (n ¼ 7). efficacies of medicinal herbs for reduction of opioid dependence (26,27). We showed that SO administration could attenuate physical withdrawal precipitated by administration of naloxone to opioid-dependent rats as measured by weight loss, jumping, penis licking, teeth chattering, wet dog shakes, rearing, standing, sniffing, face grooming and paw tremor.…”

Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats

“…Similarly, honey should diminish a series of behavioral responses to morphine withdrawal. Aforesaid reviews indicated that free radicals and nitric oxide signaling play critical roles in the growth of opioid analgesic tolerance and dependence, and radical scavenging agents, as well as nitric oxide synthase inhibitors, can be possibly implemented within the avoidance of morphine tolerance and withdrawal syndrome 5,21,22,2,4 . The excessive antioxidant activity of honey and its compounds have been discovered in common reports 23,24,26,27,28 .…”

“…Immediately after naloxone injection, each animal was placed in a transparent acrylic cylinder to observe the frequency of withdrawal manifestations. Two classes of signs were distinguished: graded signs (abdominal contraction, grooming and jumping), which were quantified numerically; and checked signs (diarrhea, teeth chattering, ptosis) for which only presence or absence was evaluated 4 . On day 7, naloxone (3 mg/kg i.p.)…”

“…Withal, the user of methadone itself would cause dependency and the curative dose has been increasing over the period of time to make the same results1. Recently using of non-addictive materials have been applied to attenuate opiate dependency.These let in natural elements such as honey, habbatusauda, herb roots and so on 2,3,4 .In the advancement of oxidative stress there are two components included; arrangement of free radicals and reduction of antioxidant activity 5 . The instrument of oxidative stress in the brain overstated by opiate admissions.…”