Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis

Çakır, Ufuk; Tayman, Cüneyt; Serkant, Utku; Yakut, Halil İbrahim; Çakır, Esra; Ateş, Ufuk; Koyuncu, İsmail; Karaoğul, Eyyüp

doi:10.1016/j.jep.2018.07.009

Cited by 35 publications

(39 citation statements)

References 48 publications

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“…Bacteroides fragilis ZY-312 [113] Lactobacillus reuteri DSM 17938 [68,69] Lactobacillus reuteri ATCC PTA 4659 [68] Lactobacillus reuteri biofilm on unloaded microspheres [71,72] Lactobacillus reuteri biofilm on MRS loaded microspheres [71] Lactobacillus reuteri biofilm on sucrose loaded microspheres [72] Lactobacillus reuteri biofilm on maltose loaded microspheres [72] Bifidobacterium microcapsules [114] Bifidobacterium mixture [115] Bifidobacterium adolescentis [76] Bifidobacterium infantis [116] Bifidobacterium bifidum OLB6378 [74] Bifidobacterium breve M-16V [117] Lactobacillus rhamnosus HN001 (live) [39] Lactobacillus rhamnosus HN001 (dead) [39] Lactobacillus rhamnosus isolated DNA [39] Probiotic mixture (Bifidobacterium animalis DSM15954, Lactobacillus acidophilus DSM13241, Lactobacillus casei ATCC55544, Lactobacillus pentosus DSM14025 and Lactobacillus plantarum DSM13367) [77] CpG-DNA [39] Other interventions Bovine milk exosomes [118] Native human breast milk exosomes [78,119] Pasteurized human breast milk exosomes [119] Preterm human breast milk exosomes [120] Ginger [121] Fennel seed extracts [122] Amniotic fluid [40,63,123] Curcumin [124] Sesamol [125] Astragaloside iv [126] Resveratrol [127] Berberine [79] Surfactant protein a [80] Human β-defensin-3 [81] PUFA, polyunsaturated fatty acids; MPL milk polar lipids; MFGM, milk fat...…”

Section: Probiotic Interventionsmentioning

confidence: 99%

Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies

et al. 2021

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Necrotizing enterocolitis (NEC), which is characterized by severe intestinal inflammation and in advanced stages necrosis, is a gastrointestinal emergency in the neonate with high mortality and morbidity. Despite advancing medical care, effective prevention strategies remain sparse. Factors contributing to the complex pathogenesis of NEC include immaturity of the intestinal immune defense, barrier function, motility and local circulatory regulation and abnormal microbial colonization. Interestingly, enteral feeding is regarded as an important modifiable factor influencing NEC pathogenesis. Moreover, breast milk, which forms the currently most effective prevention strategy, contains many bioactive components that are known to support neonatal immune development and promote healthy gut colonization. This systematic review describes the effect of different enteral feeding interventions on the prevention of NEC incidence and severity and the effect on pathophysiological mechanisms of NEC, in both experimental NEC models and clinical NEC. Besides, pathophysiological mechanisms involved in human NEC development are briefly described to give context for the findings of altered pathophysiological mechanisms of NEC by enteral feeding interventions.

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Section: Probiotic Interventionsmentioning

confidence: 99%

Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies

et al. 2021

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“…It is widely distributed and used in Asian countries as a traditional medicine for a wide array of conditions, including nausea, vomiting, colds, fever, and rheumatic disorders [ 15 ]. Several studies report that ginger and its active components have antimicrobial [ 16 ], antioxidant [ 17 ], and anti-inflammatory properties [ 18 ]. Ginger extract showed its protective effects by reducing lipid peroxidation and enhancing antioxidant enzyme activities in mycotoxin-treated HepG2 cell lines [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats

et al. 2020

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Ginger (Zingiber officianale), the most widely consumed species, is traditionally used as a folk medicine to treat some inflammatory diseases in China and Korea. However, the functional activity of steamed ginger extract on gastric ulcers has not been previously explored. The present study aimed to investigate antiulcer activity of steamed ginger extract (GGE03) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model. GGE03 (100 mg/kg) was orally administered for 14 days to rats before oral intubation of an EtOH/HCl mixture to induce gastric damage. Pretreatment with GGE03 markedly protected the formation of microscopic pathological damage in the gastric mucosa. Further, administration of GGE03 significantly increased mucosal total nitrate/nitrite production in gastric tissues, and elevated total GSH content, catalase activity and superoxide dismutase (SOD) expression as well as decreasing lipid peroxidation and myeloperoxidase (MPO) activity. Underlying protective mechanisms were examined by assessing inflammation-related genes, including nuclear factor-κB (NF-κB), prostaglandin E2 (PGE2), and pro-inflammatory cytokines levels. GGE03 administration significantly reduced the expression of NF-κB and pro-inflammatory cytokines. Our findings suggest that GGE03 possesses antiulcer activity by attenuating oxidative stress and inflammatory responses.

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“…Less severe intestinal damage and apoptosis were found in intestinal tissues of rat pups that treated with phenolic rich ginger extracts (1,000 mg/kg, p.o. ), compared to that observed for NEC alone (Cakir et al, 2018). It has been indicated that dried ginger and its components, such as 6‐shogaol, produced a marked increase in the intestinal blood flow, which may be useful in treatment of intestinal ischemia‐related diseases (Murata et al, 2002).…”

Section: Pharmacological Activities and Mechanism Of Actionmentioning

confidence: 62%

Ginger (Zingiber officinaleRosc.) and its bioactive components are potential resources for health beneficial agents

Zhang

Zhao

Wang

et al. 2020

Phytotherapy Research

133

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Zingiber officinale Rosc. (Zingiberacae), commonly known as ginger, is a perennial and herbaceous plant with long cultivation history. Ginger rhizome is one of the most popular food spices with unique pungent flavor and is prescribed as a well‐known traditional Chinese herbal medicine. To date, over 160 constituents, including volatile oil, gingerol analogues, diarylheptanoids, phenylalkanoids, sulfonates, steroids, and monoterpenoid glycosides compounds, have been isolated and identified from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially gastrointestinal‐protective, anti‐cancer, and obesity‐preventive effects. In addition, gingerol analogues such as 6‐gingerol and 6‐shogaol can be rapidly eliminated in the serum and detected as glucuronide and sulfate conjugates. Structural variation would be useful to improve the metabolic characteristics and bioactivities of lead compounds derived from ginger. Furthermore, some clinical trials have indicated that ginger can be consumed for attenuating nausea and vomiting during early pregnancy; however, there is not sufficient data available to rule out its potential toxicity, which should be monitored especially over longer periods. This review provides an up‐to‐date understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.

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Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis

Cited by 35 publications

References 48 publications

Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies

Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies

Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats

Ginger (Zingiber officinaleRosc.) and its bioactive components are potential resources for health beneficial agents

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