Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats

Shin, Jung Kyong; Park, Jae Hyeon; Kim, Kyeong Seok; Kang, Tong Ho; Kim, Hyung Sik

doi:10.3390/molecules25204663

Cited by 27 publications

(28 citation statements)

References 55 publications

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“…Furthermore, we calculated the human equivalent dose for the effect of GGE03. GGE03 was found to protect against EtOH/HCL-induced rat gastric mucosal injury at concentrations of 100 to 300 mg/kg [5]. Based on our findings and others, we estimate that an amount of 400 to 1,000 mg/day GGE03 is required for a 60 kg subject as calculated by the recommended body surface area normalization method [37].…”

Section: Discussionsupporting

confidence: 56%

“…GGE03 was prepared as previously published [5]. Briefly, ginger was washed three times with distilled water, dried at 50°C for 30 hours, and then steamed at: 2 to 2.5 kgf/cm 2 , 97°C, for 2 hours.…”

Section: Preparation Of Steamed Ginger Extract (Gge03)mentioning

confidence: 99%

“…Ginger has been used to treat stomachache, fever, vomiting and primary dysmenorrhea [1,2], and has an anti-inflammatory, anti-microbial and anti-oxidative properties [3]. Interestingly, recent studies have revealed that steamed ginger has a lower toxicity and higher efficacy than the dried ginger [4,5]. During the process of steaming, the bioactive components were affected, and this apparently enhanced the biological activities of ginger [6].…”

Section: Introductionmentioning

confidence: 99%

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Steamed Ginger Extract Exerts Anti-inflammatory Effects in Helicobacter pylori-infected Gastric Epithelial Cells through Inhibition of NF-κB

Song

Lee

Park³

et al. 2021

J Cancer Prev

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Ginger (Zingiber officinale) has traditionally been used as a treatment for inflammatory diseases in the Asian region. Recently, anti-inflammatory effects of steamed ginger extract (GGE03) have been reported, but its association with Helicobacter pylori (H. pylori)-induced gastritis has not been investigated. The purpose of this study was to assess the anti-inflammatory activity of GGE03 in H. pylori-infected gastric epithelial cells. Our studies revealed that the GGE03 suppressed the growth of H. pylori. GGE03 markedly reduced the expression of the H. pylori-induced pro-inflammatory cytokines including interleukin (IL)-8, TNF-α, IL-6, inducible NOS (iNOS) and IFN-γ. We also demonstrated that GGE03 treatment inhibited the H. pylori-activated NF-κB signaling pathway. In addition, the treatment with GGE03 significantly attenuated nitric oxide production and myeloperoxidase activity in H. pylori-infected gastric epithelial cells. These anti-inflammatory effects of GGE03 were more effective than ginger extract. Finally, we investigated the minimum effective concentration of GGE03 to inhibit H. pylori-induced inflammation. Our findings suggest that GGE03 not only inhibits the growth of H. pylori, but also attenuates H. pylori-induced inflammation.

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Section: Discussionsupporting

confidence: 56%

Section: Preparation Of Steamed Ginger Extract (Gge03)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Steamed Ginger Extract Exerts Anti-inflammatory Effects in Helicobacter pylori-infected Gastric Epithelial Cells through Inhibition of NF-κB

Song

Lee

Park³

et al. 2021

J Cancer Prev

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“…The findings concluded that steamed ginger extract may exhibit antiulcer activity in a rat model by reducing acute gastric ulcers. The preventive mechanism probably comes as a result of an increase in mucosal prostaglandin E2 synthesis and gastric antioxidation capability [ 157 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

Boakye-Yiadom

Kumadoh

Adase

et al. 2021

BioMed Research International

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Background. The growth or multiplication of harmful microorganisms in addition to harmful human activities has led to many disorders in humans. Consequently, there is a search for medications to treat these disorders. Interestingly, medicines of plant origin are known to be among the most attractive sources of new drugs and have shown promising results in the treatment of various diseases including peptic ulcers. This review, therefore, is aimed at obtaining knowledge on some Ghanaian ethnomedicinal plants used to treat peptic ulcers, their folkloric uses, their phytochemicals, and their antiulcer and related pharmacological activities as well as finding areas for prospective studies.Methods. Published peer-reviewed articles on ethnomedicinal plants used for the management of peptic ulcers in Ghana from 1967 to 2020 were sourced and used for the study. Results. In this review, 13 plants were identified which belong to 10 different families including Sapindaceae, Apocynaceae, and Bignoniaceae. The parts most often used for most preparations were the leaves (53%), followed by stem bark and roots (both having the same percentage of use of 17.6%), the whole plant (5.9%), and the rhizomes (5.9%). Azadirachta indica was the only plant that had undergone some patient studies in addition to animal studies. Conclusion. A discussion of various antiulcer activity studies using ulcer models carried out on selected medicinal plants used for the management of peptic ulcer disease in addition to brief information on their folkloric uses and their phytochemical and other pharmacological properties is presented. These medicinal plants may be used in developing herbal products for the management of peptic ulcer disease.

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“…In addition, a previous study reported that oxidative stress during gastric inflammation induced by ethanol stimulates lipid peroxidation, as indicated by elevated malondialdehyde (MDA) levels in gastric tissues [ 4 ]. Nuclear factor kappa B (NF-κB) activation occurs during mucosal inflammation induced by gastric ulcer disease.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective and Antioxidative Effects of the Traditional Thai Polyherbal Formula Phy-Blica-D against Ethanol-Induced Gastric Ulcers in Rats

et al. 2021

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Phy-Blica-D is a traditional Thai polyherbal formula that has reduced oxidative stress in non-communicable diseases. However, evidence supporting the gastroprotective effects of Phy-Blica-D has not been previously reported. Therefore, this study aimed to evaluate the gastroprotective effects of Phy-Blica-D against gastric ulcers in rats and investigate the potential underlying mechanism. To estimate the possible mechanisms of action, we examined the levels of oxidative stress markers, such as reactive oxygen species (ROS) and malondialdehyde (MDA), as well as antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH). According to our results, rats treated with only 80% ethanol (vehicle group) exhibited significant increases in their ulcer area and ulcer index (UI). Moreover, the levels of ROS and MDA markedly increased in the vehicle group compared with the normal control group. Daily oral administration of Phy-Blica-D (500 and 1000 mg/kg) for 7 days not only significantly decreased the ulcer area and UI, but also remarkably decreased the ROS and MDA levels in gastric tissue. Gastric ulcers induced by ethanol had significantly decreased antioxidant enzyme activities (CAT and SOD) and non-enzymatic antioxidant (GSH), whereas pretreatment with Phy-Blica-D significantly improved the activities of CAT, SOD, and GSH. Moreover, after exposure to ethanol, the rats exhibited a significantly increased level of inducible nitric oxide synthase (iNOS), which was reduced after treatment with Phy-Blica-D. These findings suggest that Phy-Blica-D potentially exerts its gastroprotective effects by suppressing oxidative stress and stimulating antioxidant enzymes, which is one of the causes of destruction of cell membranes, and it is involved in the pathogenesis of acute gastric ulcers induced by ethanol.

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Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats

Cited by 27 publications

References 55 publications

Steamed Ginger Extract Exerts Anti-inflammatory Effects in Helicobacter pylori-infected Gastric Epithelial Cells through Inhibition of NF-κB

Steamed Ginger Extract Exerts Anti-inflammatory Effects in Helicobacter pylori-infected Gastric Epithelial Cells through Inhibition of NF-κB

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

Gastroprotective and Antioxidative Effects of the Traditional Thai Polyherbal Formula Phy-Blica-D against Ethanol-Induced Gastric Ulcers in Rats

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