Abstract:Phy-Blica-D is a traditional Thai polyherbal formula that has reduced oxidative stress in non-communicable diseases. However, evidence supporting the gastroprotective effects of Phy-Blica-D has not been previously reported. Therefore, this study aimed to evaluate the gastroprotective effects of Phy-Blica-D against gastric ulcers in rats and investigate the potential underlying mechanism. To estimate the possible mechanisms of action, we examined the levels of oxidative stress markers, such as reactive oxygen s… Show more
“…C. acaulis root methanol extract showed EC 50 of 208 µg/mL, while the essential oil of C. acanthifolia demonstrated EC 50 of 13.6 µg/mL according to DPPH assay. According some authors the anti-inflammatory and gastroprotective properties of this plant could be explained with the antioxidant activity [6,25,29]. Additionally, CH 2 Cl 2 extract of the C. acaulis roots demonstrated in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydracyl assay and in vivo antioxidant activity was shown for C. elegans mode [15].…”
Section: Total Polyphenols and Antioxidant Activitymentioning
Green extraction methods present a perspective approach for the isolation of bioactive molecules. Together with an ecofriendly approach to extraction, there are many undervalued plants - a rich of source of prebiotics and phenolic compounds. Carlina acanthifolia L. roots possessed antimicrobial, anti-inflammatory, and anti-ulcer properties due to the diverse bioactive compounds in them. Detailed information about inulin-type fructan in its roots is still absent. The object of this work was to define inulin, sugars, and phenolic content, the antioxidant activity in the water, and 70 % ethanol extract resulting from ultrasound-assisted extraction (UAE) and pressure-liquid extraction (PLE). The results showed that the total fructans reached 12.6±0.2 g/100 g dw. Inulin was found in water extracts (6.82 g/100 g dw) in the prevalence of ultrasound-assisted extracts. Total phenolic content did to not exceed 15.25 mg GAE/g dw. Additionally, the antioxidant activities were in the range from 5.99 to 205.83 μM TE/g dw. In conclusion, water extracts from UAE demonstrated higher levels of bioactive compounds with antioxidantive properties, probably due to cavitation process. However, this study is the first detailed investigation for fructans and polyphenols content, as well as antioxidant activity of Carlina acanthifolia L. roots in extracts obtained by green methods. Therefore, this research enriched the information of bioactive compounds in Carlina acanthifolia L. roots.
“…C. acaulis root methanol extract showed EC 50 of 208 µg/mL, while the essential oil of C. acanthifolia demonstrated EC 50 of 13.6 µg/mL according to DPPH assay. According some authors the anti-inflammatory and gastroprotective properties of this plant could be explained with the antioxidant activity [6,25,29]. Additionally, CH 2 Cl 2 extract of the C. acaulis roots demonstrated in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydracyl assay and in vivo antioxidant activity was shown for C. elegans mode [15].…”
Section: Total Polyphenols and Antioxidant Activitymentioning
Green extraction methods present a perspective approach for the isolation of bioactive molecules. Together with an ecofriendly approach to extraction, there are many undervalued plants - a rich of source of prebiotics and phenolic compounds. Carlina acanthifolia L. roots possessed antimicrobial, anti-inflammatory, and anti-ulcer properties due to the diverse bioactive compounds in them. Detailed information about inulin-type fructan in its roots is still absent. The object of this work was to define inulin, sugars, and phenolic content, the antioxidant activity in the water, and 70 % ethanol extract resulting from ultrasound-assisted extraction (UAE) and pressure-liquid extraction (PLE). The results showed that the total fructans reached 12.6±0.2 g/100 g dw. Inulin was found in water extracts (6.82 g/100 g dw) in the prevalence of ultrasound-assisted extracts. Total phenolic content did to not exceed 15.25 mg GAE/g dw. Additionally, the antioxidant activities were in the range from 5.99 to 205.83 μM TE/g dw. In conclusion, water extracts from UAE demonstrated higher levels of bioactive compounds with antioxidantive properties, probably due to cavitation process. However, this study is the first detailed investigation for fructans and polyphenols content, as well as antioxidant activity of Carlina acanthifolia L. roots in extracts obtained by green methods. Therefore, this research enriched the information of bioactive compounds in Carlina acanthifolia L. roots.
“…Thus the authors concluded that the concealment of oxidative stress and a rise in antioxidant activity could be responsible for the mechanism of the gastroprotective effect of Phy-Blica-D. As reported in the earlier findings, the phytoconstituents possessed free radical scavenging and gastroprotective effects, which could be responsible for the therapeutic benefit of the formulation. 25 ijlpr 2022; doi 10.22376/ijpbs/lpr.2022.12.6.P77-86…”
An imbalance in the aggressive factors and protective factors in the gastrointestinal tract leads to peptic ulcers. Modern medicinal prescriptions for ulcers involve the use of allopathic drugs. However, several disadvantages, such as side effects, discordancy, and altered physiological aspects, have led to the quest for alternative safer medications. The use of herbs to treat ulcers has been practiced for decades in Ayurveda. A combination of such herbs, known as polyherbal formulation, shows several advantages like synergistically augmented beneficial effects, better patient compliance, and reduction in dose of individual drugs without compromising the therapeutic effects. In recent years, this valuable traditional knowledge of the medicinal values of herbs, along with current value-added developments, has ensured the usage of improved Ayurvedic medicine in a milieu of treatments. In the last two decades, many polyherbal formulations have been developed and evaluated for their antiulcer potential. The advancements in analytical methods have even led to the isolation of the phytoconstituents from crude herbal drugs, and their benefits in therapeutics have been studied. The core aim of the current review is to enlighten the comprehensive overview of the composition of some marketed antiulcer polyherbal formulations and the preclinical models to prove their gastroprotective potentials based on scientific findings.
“…The pathophysiology of gastric ulcers is an imbalance between gastric mucosa-protecting and gastric mucosa-destroying due to acid secretions. Infectious diseases, smoking, stress, prolonged use of steroidal as well nonsteroidal antiinflammatory medicines, and excessive alcohol intake are also contributing factors that produce this imbalance [ 8 ]. Herbal medicines are alternative source of medicine that can cure a variety of gastroprotective mechanisms, such as the promotion of mucosal proliferation, suppression of acid, wound healing characteristics, production, and antioxidant capabilities [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Infectious diseases, smoking, stress, prolonged use of steroidal as well nonsteroidal antiinflammatory medicines, and excessive alcohol intake are also contributing factors that produce this imbalance [ 8 ]. Herbal medicines are alternative source of medicine that can cure a variety of gastroprotective mechanisms, such as the promotion of mucosal proliferation, suppression of acid, wound healing characteristics, production, and antioxidant capabilities [ 8 ]. The present study focused on demonstrating the chemical characterization through cold methanolic extraction and the ulcer healing properties of Lactuca sativa (LPL) leaf powder.…”
The objective of this study was to characterize the bioactive ingredients and antiulcer effects of Lactuca sativa leaves. Several bioactive chemicals were found in the cold methanolic extract of Lactuca sativa leaves after gas chromatography-mass spectrometry (GC-MS) research: 9,12-octadecadienoic acid (Z,Z)-, cyclononasiloxane, octadecamethyl-, n-hexadecanoic acid, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl, octadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, 9-octadecenamide, (Z)-, hexadecanoic acid, stigmasterol, benzothiazole, ethyl iso-allocholate, and octacosane. Distinct fingerprint regions in GCMS indicated the existence of bioactive compounds. The leaf powder of Lactuca sativa (LPL) demonstrated substantial antiulcer properties at 400 mg/kg, which was almost equivalent to the standard drug at 20 mg/kg. The cytokine network was efficiently regulated by reducing the production of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. The levels of caspase-3 and caspase-9 were also considerably lowered at p < 0.05 significant level.
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