Ginger reserves testicular spermatogenesis and steroidogenesis in difenoconazole‐intoxicated rats by conducting oxidative stress, apoptosis and proliferation

Abstract

Endocrine-disrupting chemicals (EDCs) can disrupt the endocrine system by interfering with the production, release, transport and metabolism or elimination of natural hormones (Kahn et al., 2020).Consequently, they may induce testicular dysgenesis syndrome by impairing the proliferation and development of testicular cells, which disrupts spermatogenesis (Chang et al., 2015) and steroidogenesis pathways (Sharma et al., 2020).Many classes of pesticides, especially fungicides, act as EDCs, and this behaviour depends on the level and duration of exposure (Mnif et al., 2011). The antifungal activity of triazoles occurs through

Development of a highly sensitive colloidal gold semiquantitative method for the determination of difenoconazole residues in citrus

“…Difenoconazole (DIFE) is a broad-spectrum, high-efficiency triazole systemic fungicide, which inhibits the growth of fungi by inhibiting the germination of pathogen spores, leading to their death, and has a preventive effect on vegetables, fruit trees, cereals, and other crops, with high adhesion and low degradability ( 1 ). In view of the high risk of DIFE to fish ( 2 ) and mammals ( 3 ) and its high levels in indoor dust ( 4 ) and water bodies ( 5 ), to prevent excessive intake of DIFE by humans, the residue limit of DIFE has been clearly set in GB.2763–2021 National Food Safety Standard - Maximum Residue Limit of Pesticides in Foods ( 6 ) issued by China, which is 0.01 mg/kg per person as the tolerable daily intake. Citrus is the main fruit crop, with an annual production of more than 100 million tons, and the production of oranges and tangerines alone reaches more than 50 million tons ( 7 ), making it one of the most vital cash crops in the world ( 8 ).…”

Water-Based Environmentally Friendly Pesticide Formulations Based on Cyclodextrin/Pesticide Loading System

“…Difenoconazole (DIF) is a representative variety of broad-spectrum triazole fungicides and liposoluble pesticides developed by Giba Geigy in 1988 [9][10][11]. DIF destroys the fungal cell membrane by interfering with ergosterol biosynthesis [12,13]. As a broad-spectrum fungicide, DIF is applicated worldwide in controlling diseases in vegetables, fruits, rice, and wheat [14][15][16][17].…”

Coenzyme Q 10 alleviates testicular endocrine and spermatogenic dysfunction induced by high‐fat diet in male Wistar rats: Role of adipokines, oxidative stress and MAPK / ERK / JNK pathway

“…In fact, increased consumption of HFD has been linked to excessive production of reactive oxygen species (ROS) in testicular cells (Khwanes et al, 2022). Increased leptin production by dysfunctional adipocytes is a direct cause for increased ROS production in adiposity (Darbandi et al, 2018).…”