Water-Based Environmentally Friendly Pesticide Formulations Based on Cyclodextrin/Pesticide Loading System

Abstract

Difenoconazole (DIF) is a representative variety of broad-spectrum triazole fungicides and liposoluble pesticides. However, the water solubility of DIF is so poor that its application is limited in plant protection. In addition, the conventional formulations of DIF always contain abundant organic solvents, which may cause pollution of the environment. In this study, two DIF/cyclodextrins (CDs) inclusion complexes (ICs) were successfully prepared, which were DIF/β-CD IC and DIF/hydroxypropyl-β-CD IC (DIF/HP-β-CD IC). The effect of cyclodextrins on the water solubility and the antifungal effect of liposoluble DIF pesticide were investigated. According to the phase solubility test, the molar ratio and apparent stability constant of ICs were obtained. Fourier transform infrared spectroscopy, thermal gravity analysis, X-ray diffraction and scanning electron microscopy were used systematically to characterize the formation and characteristics of ICs. The results noted that DIF successfully entered the cavities of two CDs. In addition, the antifungal effect test proved the better performance of DIF/HP-β-CD IC, which exceeded that of DIF emulsifiable concentrate. Therefore, our study provides informative direction for the intelligent use of liposoluble pesticides with cyclodextrins to develop water-based environmentally friendly formulations.

Photoresponsive Vesicles of Pendimethalin, γ-Cyclodextrin, and an Azobenzene for Controlled Release of a Pesticide

“…It improves the degree of dispersion of hydrophobic drugs and enhances chemical stability. It is an excellent ligand for the formation of self-assembled inclusion complexes. − The configuration inversion of azobenzene has long been a focal point of research in the field of photoresponsive materials, UV/light-induced azobenzene isomerization reversal process has great potential for applications in nanosystems . Azobenzene can exist in two isomeric forms, trans- and cis- , and these isomers undergo mutual transformation upon exposure to light.…”