Ginger (<i>Zingiber officinale</i> Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Sahardi, Nur Fatin Nabilah Mohd; Makpol, Suzana

doi:10.1155/2019/5054395

Cited by 69 publications

(65 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, powder of ginger can decrease the level of glucose and activate inflammatory activity which can lead to the development of insulin resistance [ 176 ].…”

Section: Bioactive Compounds From Plants Having Type 2 Antidiabetimentioning

confidence: 99%

Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

Tran

Bao

2020

Biology

265

165

View full text Add to dashboard Cite

Natural products, including organisms (plants, animals, or microorganisms) have been shown to possess health benefits for animals and humans. According to the estimation of the World Health Organization, in developing countries, 80% of the population has still depended on traditional medicines or folk medicines which are mostly prepared from the plant for prevention or treatment diseases. Traditional medicine from plant extracts has proved to be more affordable, clinically effective and relatively less adverse effects than modern drugs. Literature shows that the attention on the application of phytochemical constituents of medicinal plants in the pharmaceutical industry has increased significantly. Plant-derived secondary metabolites are small molecules or macromolecules biosynthesized in plants including steroids, alkaloids, phenolic, lignans, carbohydrates and glycosides, etc. that possess a diversity of biological properties beneficial to humans, such as their antiallergic, anticancer, antimicrobial, anti-inflammatory, antidiabetic and antioxidant activities Diabetes mellitus is a chronic disease result of metabolic disorders in pancreas β-cells that have hyperglycemia. Hyperglycemia can be caused by a deficiency of insulin production by pancreatic (Type 1 diabetes mellitus) or insufficiency of insulin production in the face of insulin resistance (Type 2 diabetes mellitus). The current medications of diabetes mellitus focus on controlling and lowering blood glucose levels in the vessel to a normal level. However, most modern drugs have many side effects causing some serious medical problems during a period of treating. Therefore, traditional medicines have been used for a long time and play an important role as alternative medicines. Moreover, during the past few years, some of the new bioactive drugs isolated from plants showed antidiabetic activity with more efficacy than oral hypoglycemic agents used in clinical therapy. Traditional medicine performed a good clinical practice and is showing a bright future in the therapy of diabetes mellitus. World Health Organization has pointed out this prevention of diabetes and its complications is not only a major challenge for the future, but essential if health for all is to be attained. Therefore, this paper briefly reviews active compounds, and pharmacological effects of some popular plants which have been widely used in diabetic treatment. Morphological data from V-herb database of each species was also included for plant identification.

show abstract

“…Furthermore, powder of ginger can decrease the level of glucose and activate inflammatory activity which can lead to the development of insulin resistance [ 176 ].…”

Section: Bioactive Compounds From Plants Having Type 2 Antidiabetimentioning

confidence: 99%

Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

Tran

Bao

2020

Biology

265

165

View full text Add to dashboard Cite

show abstract

“…Our results showed that ZO extract given in combination with the obesogenic diet led to a significant reduction of damage in the peripheral blood and liver ( Figure 6). Ginger consists of two major active components, 6gingerol and 6-shogaol, which are essential for preventing oxidative stress and inflammation (78) . These bioactive compounds are able to reduce oxidative stress levels and the intake of ZO extract can therefore induce antigenotoxic effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of Zingiber officinale extract supplementation on metabolic and genotoxic parameters in diet-induced obesity in mice

et al. 2020

View full text Add to dashboard Cite

“…Ginger ( Zingiber officinale Roscoe, Zingiberaceae) has been used for thousands of years as a spice, and it has been considered to be an important ingredient in traditional Chinese medicine for the treatment of certain diseases, such as diabetes, cardiovascular diseases, rheumatism, and cancer [1,2,3,4,5,6,7,8]. In the last decade, there has also been progress in the study of other biological properties of ginger, such as its antifungal and antimicrobial capacity [9].…”

Section: Introductionmentioning

confidence: 99%

“…Gingerols and shogaols are groups of volatile phenolic compounds, and they are mainly responsible for the pungency of the rhizome [11]. It has been reported that 6-shogaol has better biological activities than 6-gingerol, especially in relation to antitumor activity [8,12].…”

Section: Introductionmentioning

confidence: 99%

Effect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells

et al. 2019

View full text Add to dashboard Cite

Ginger is a plant that is native to southern China. In the last decade and research on the components of ginger has significantly increased; of these components, 6-shogaol exhibits the greatest potential antitumor capacity. However, the molecular mechanism through which 6-shogaol exerts its effects has not yet been elucidated. In this study, the effect of 6-shogaol on tumor cells that were derived from human fibrosarcoma (HT1080) was evaluated. Cell viability was determined by a (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT assay testing different concentrations of 6-shogaol (2.5–150 μM). Subsequently, the effect of 6-shogaol on reactive oxygen species (ROS) production, glucose uptake, and protein expression of the signaling pathway phosphatase and tensin homolog/ protein kinase B /mammalian target of rapamycin (PTEN/Akt/mTOR) was measured. 6-Shogaol reduced the viability of the tumor cells and caused an increase in ROS production, which was attenuated with the addition of N-acetylcysteine, and the recovery of cell viability was observed. The increase in ROS production in response to 6-shogaol was associated with cell death. Similarly, glucose uptake decreased with incremental concentrations of 6-shogaol, and an increase in the expression of mTOR-p and Akt-p proteins was observed; PTEN was active in all the treatments with 6-shogaol. Thus, the results suggest that cells activate uncontrolled signaling pathways, such as phosphoinositide 3-kinase (PI3K)/Akt/mTOR, among other alternative mechanisms of metabolic modulation and of survival in order to counteract the pro-oxidant effect of 6-shogaol and the decrease in glucose uptake. Interestingly, a differential response was observed when non-cancerous cells were treated with 6-shogaol.

show abstract

Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Cited by 69 publications

References 104 publications

Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

Effects of Zingiber officinale extract supplementation on metabolic and genotoxic parameters in diet-induced obesity in mice

Effect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells

Contact Info

Product

Resources

About