Effects of <i>Zingiber officinale</i> extract supplementation on metabolic and genotoxic parameters in diet-induced obesity in mice

Luciano, Thais F.; Souza, Cláudio Teodoro de; Pinho, Ricardo A.; Marques, Schérolin de Oliveira; Luiz, Gabriel Paulino; Tramontin, Natalia dos Santos; Andrade, Vanessa Moraes de; Müller, Alexandre Pastoris

doi:10.1017/s0007114520005073

Cited by 5 publications

(2 citation statements)

References 81 publications

(92 reference statements)

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“…A dry extract of ZO was acquired from Essential Nutrition® (Florianóplis, Brazil), presenting 5.2% gingerols (6-gingerdiol, 6-gingerol, 8-gingerol, 6-shagaol, 10-gingerol). The extract was dissolved in drinking water and supplemented at a dose of 400 mg/kg•day by oral gavage for 35 consecutive days, this dose is safe for chronic treatment (Nammi et al 2009;Luciano et al 2021). In addition, nonsupplemented groups (DIO + vehicle and CNT + vehicle) were supplemented daily with potable water via oral gavage for 35 days.…”

Section: Zo Supplementationmentioning

confidence: 99%

Reversal of High-Fat Diet-Induced Cognitive Impairment and Oxidative Stress in the Brain through Zingiber officinale Supplementation

Luciano,

Souza,

Oilveira

et al. 2024

Preprint

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Obesity presents a significant health concern, correlating with various adverse health outcomes. Diet-induced obesity (DIO) has been associated with impair on cognitive function. Pharmacological treatments for obesity are limited and may pose serious adverse effects. Ginger possess anti-inflammatory and antioxidant effects in addition to metabolic effects. The study aimed to assess the effects of ginger supplementation on cognitive function, anxiety levels, neurotrophin levels, as well as inflammatory and oxidative status in the cortex following DIO in mice. Swiss male mice, 2 months old, were fed with DIO or standard chow for 4 months and after were subdivided into (n=10/group): i) CNT (CNT + vehicle); ii) CNT supplemented with ZO (CNT + ZO); iii) obese mice (DIO + vehicle) ; iv) obese mice supplemented with ZO (DIO + ZO) (n=10). Zingiber officinale (ZO) 400 mg/kg/day were supplemented for 35 days by oral gavage. DIO + vehicle group shown impaired on recognition memory task. CNT + ZO group showed a higher number of crossings in the open field. There were no difference between group in plus maze task. DIO + vehicle had increased the DCFH and carbonylation levels in cortex. The DIO + vehicle showed a reduction in catalase activity. The cerebral cortex did not show any difference regarding to inflammatory and neurotrophins markers. In conclusion, our findings indicate that supplementation with ZO reverses cognitive impairment in DIO mice and enhances antioxidant status in the cerebral cortex.

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Section: Zo Supplementationmentioning

confidence: 99%

Reversal of High-Fat Diet-Induced Cognitive Impairment and Oxidative Stress in the Brain through Zingiber officinale Supplementation

Luciano,

Souza,

Oilveira

et al. 2024

Preprint

Self Cite

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“…Research on the effects of anthelmintics as an herb has been reported by several researchers before. anthelmintic activity through testing of hydroalcoholic extracts of Zingiber officinale and Curcuma longa at exposure concentrations of 50 mg/ml found mean mortality times of 5.2 minutes and 4.6 minutes [8]. Both extracts exhibit the same synergistic effect as a reliable anthelmintic effect.…”

Section: Introductionmentioning

confidence: 95%

Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm

ISMAIL,

SUNARYO,

KORDJA

et al. 2024

jrp

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Helminths disease is one of the infectious diseases caused by the entry of parasites in the form of worm eggs into the human body through the human digestive tract due to pollution through the soil-transmitted helminth (STH). This study measured the in vitro effect of Areca catechu ethanol extract partitioning as anthelmintic against Ascaris lumbricoides worms using a 125 mg pyrantel pamoate control. The test animals used were living and mobile worms of A. lumbricoides, which were taken from the small intestines of pigs. The study group was divided into 5 groups, namely positive control (pyrantel pamoate ) 125 mg), negative control (0.9% NaCl solution) and ethanol extract group A. catechu 10%, 20%, 30%. The results confirmed that the ethanol extract partition of A. catechu at exposure to a concentration of 30% showed a high level of efficacy in killing worms with an average time of death of A. lumbricoides worms at 6 to 12 hours compared to pyrantel pamoat solution. However, at exposure to concentration, 10% and 20% obtained a slightly longer average mortality time of 8 to 24 hours, respectively. Partitioning of A. catechu ethanol extract at a concentration of 30% showed the highest level of efficacy in killing A. lumbricoides worms based on average faster mortality time than the concentrations of 10% and 20% collected. Ethanol extract A. catechu has pharmacological therapeutic effects have various properties, including can be used for the treatment of diseases caused by parasites and also several other diseases.

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Reversal of high-fat diet-induced cognitive impairment and oxidative stress in the brain through Zingiber officinale supplementation

Luciano,

Teodoro de Souza,

de Oliveira

et al. 2024

Metab Brain Dis

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Effects of Zingiber officinale extract supplementation on metabolic and genotoxic parameters in diet-induced obesity in mice

Cited by 5 publications

References 81 publications

Reversal of High-Fat Diet-Induced Cognitive Impairment and Oxidative Stress in the Brain through Zingiber officinale Supplementation

Reversal of High-Fat Diet-Induced Cognitive Impairment and Oxidative Stress in the Brain through Zingiber officinale Supplementation

Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm

Reversal of high-fat diet-induced cognitive impairment and oxidative stress in the brain through Zingiber officinale supplementation

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