Ginger extract attenuates ethanol-induced pulmonary
histological changes and oxidative stress in rats

Shirpoor, Alireza; Gharalari, Farzaneh Hosseini; Rasmi, Yousef; Heshmati, Elaheh

doi:10.7555/jbr.31.20160151

Cited by 8 publications

(3 citation statements)

References 31 publications

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“…The antioxidant effects of the active compounds of ginger, specifically gingerol and shogaol, on heart structure can also be seen through the inhibition of leukotriene and prostaglandin biosynthesis by suppressing 5-lipooxygenase synthetase [94]. This finding was similar to the finding from a study by Shirpoor et al [95], which showed that the lung abnormalities induced by oxidative stress can be improved by the antioxidant and anti-inflammatory properties of ginger.…”

Section: Ginger As An Antioxidant Involved In Delaying Ageingsupporting

confidence: 79%

Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Sahardi

Makpol

2019

Evidence-Based Complementary and Alternative Medicine

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Currently, the age of the population is increasing as a result of increased life expectancy. Ageing is defined as the progressive loss of physiological integrity, which can be characterized by functional impairment and high vulnerability to various types of diseases, such as diabetes, hypertension, Alzheimer’s disease (AD), Parkinson’s disease (PD), and atherosclerosis. Numerous studies have reported that the presence of oxidative stress and inflammation contributes to the development of these diseases. In general, oxidative stress could induce proinflammatory cytokines and reduce cellular antioxidant capacity. Increased oxidative stress levels beyond the production of antioxidant agents cause oxidative damage to biological molecules, including DNA, protein, and carbohydrates, which affects normal cell signalling, cell growth, differentiation, and apoptosis and leads to disease pathogenesis. Since oxidative stress and inflammation contribute to these diseases, ginger (Zingiber officinale Roscoe) is one of the potential herbs that can be used to reduce the level of oxidative stress and inflammation. Ginger consists of two major active components, 6-gingerol and 6-shogaol, which are essential for preventing oxidative stress and inflammation. Thus, this paper will review the effects of ginger on ageing and degenerative diseases, including AD, PD, type 2 diabetes mellitus (DM), hypertension, and osteoarthritis.

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Section: Ginger As An Antioxidant Involved In Delaying Ageingsupporting

confidence: 79%

Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Sahardi

Makpol

2019

Evidence-Based Complementary and Alternative Medicine

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“…Previous studies indicate that alcohol induced DNA damage and oxidative stress are associated with cancer risk, and promoted tumor metastasis [34][35][36]. According to epidemiological evidence, alcohol might play a causative role in developing oral cancer [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Expressional and Functional Characterization of Intracellular pH Regulators and Effects of Ethanol in Human Oral Epidermoid Carcinoma Cells

Lee

Chao

Huang

et al. 2018

Cell Physiol Biochem

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Background/Aims: To functionally characterize intracellular pH (pH_i) regulating mechanisms, such as Na⁺-H⁺ exchanger (NHE) and Na⁺-HCO₃^- co-transporter (NBC), and further examine effects of ethanol on the pH_i regulating mechanism in human oral epidermoid carcinoma (OEC-M1) cells. Methods: OEC-M1 cells were a gift from Tri-Service General Hospital. Changes of pH_i were detected by microspectrofluroimetry with a pH-sensitive fluorescent dye, BCECF. Isoforms of transporters were examined by Western blot technique. Results: i) the steady-state pH_i value shifted from alkaline (7.35∼7.49) to acidic (7.0∼7.03) following acid/base impacts; ii) in HEPES-buffer system, pH_i recovery following induced-acidification was totally blocked by either removing [Na]_o⁺ or adding HOE 694 (a NHE1 specific inhibitor), which demonstrates existence of NHE1; iii) in HCO₃^-/CO₂-buffer system, the pH_i recovery following induced-acidification was entirely blocked by either removing [Na]_o⁺ or adding HOE 694 plus DIDS (a NBC specific inhibitor), which suggests existence of Na⁺- and HCO₃^–dependent acid-extruder, i.e. NBC; iv) the isoforms of the two acid extruders were NHE1, NBCn1, NBCe1 and NDCBE; v) ethanol (10-1000 mM) showed a biphasic and concentration-dependent effect on resting pH_i (i.e. increase then decrease) by changing the activity of NHE1 and NBC accordingly; vi) treatment with ethanol for 24 hr (> 300 mM) significantly inhibited the expression of NHE1, NBCn1 and NDCBE, while up-regulated NBCe1. Conclusions: Ethanol affects pH_i in a concentration-dependent manner by changing function and expression of NHE1 and NBC isoforms in OEC-M1 cells.

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“…Ameliorative effects of H. sabdariffa on pulmonary fibrosis and chronic inflammatory interstitial lung disease have also been studied using rats exposed to a toxic chemical (Hemmeti et al 2016, Ajibade et al 2021. It has been demonstrated that pre-treatment using Z. officinale extract improves lung function and normalizes lung injuries in alcoholic humans and rats exposed to polychlorinated biphenyls (Alireza et al 2017, Ahd et al 2019. The administration of T. occidentalis extract to animals resulted in the repair of lung tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust

Yahaya,

Salisu,

Musa

et al. 2023

FMI

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Highlights: 1. This study identified feasible and affordable alternatives to ineffective conventional cement production pollution control strategies.2.M. oleifera, H. sabdariffa, T. occidentalis, and Z. officinale are effective as personal interventions to ameliorate the effects of cement pollution. Abstract Conventional pollution control strategies in the cement industry have proven ineffective. As a result, effective and targeted complementary interventions are necessary. This study used roof rats (Rattus rattus) inhabiting the premises of a cement plant in Sagamu, Ogun State, Nigeria, to evaluate the ameliorative effects of moringa (Moringa oleifera), roselle (Hibiscus sabdariffa), fluted pumpkin (Telfairia occidentalis), and ginger (Zingiber officinale) on cement dust exposure. A total of 42 rats were divided into seven groups, with each group consisting of six rats. Group 1 served as the negative control group and was not exposed to any substances, while group 2 served as the positive control group and received standard feed throughout the experiment. Meanwhile, groups 3, 4, 5, 6, and 7 served as the experimental group. Rats in these groups were fed with 400 mg/kg of ethanolic extracts of Z. officinale, M. oleifera, T. occidentalis, H. sabdariffa, and a mixture of the four extracts with a composition of 1:1:1:1, respectively, for 90 days. The plasma DNA concentrations, DNA purity, and lungs of the rats were examined before and after the experiment. Prior to the experiment, the exposed rats had higher plasma DNA concentrations and lower DNA purity, as well as severe fibrosis and congested alveoli in their lungs, compared to the unexposed rats. At the end of the experiment, the experimental groups showed a significant increase in DNA purity (p≤0.05) and a decline in plasma DNA concentrations compared to the positive control group. In addition, the experimental groups showed fewer histopathological abnormalities than the positive control group. The mixture of the extracts yielded the most favorable results, followed by the extracts of Z. officinale, M. oleifera, T. occidentalis, and H. sabdariffa, respectively. These findings suggested that the selected vegetables and spices have the properties to ameliorate the effects of cement dust exposure. Therefore, individuals residing in close proximity to cement plants are encouraged to consume these vegetables and spices.

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Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats

Cited by 8 publications

References 31 publications

Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Expressional and Functional Characterization of Intracellular pH Regulators and Effects of Ethanol in Human Oral Epidermoid Carcinoma Cells

Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust

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