Ginger ameliorates reproductive toxicity of formaldehyde in male mice: Evidences for Bcl-2 and Bax

Abstract

Ginger significantly ameliorates oxidative stress induced by formaldehyde toxicity in male reproductive system, therefore, this herb could be used as a natural source for inventing new drugs to cure male infertility.

Effects of intratesticular injection of hypertonic mannitol and saline on the quality of donkey sperm, indicators of oxidative stress and testicular tissue pathology

“…In mammals, intratesticular injection of calcium chloride, zinc gluconate, HM, and HS have all been tested for chemical castration [ 3 , 16 , 17 , 29 ]. Animals have been reported to be chemically, surgically and mechanically castrated [ 13 , 59 , 61 ]. Because of the risks and disadvantages of surgical castration, we must now turn to non-invasive chemical methods capable of completely stopping spermatogenesis, androgenesis, and libido.…”

“…A decrease in sperm count in animals has been found to be associated with subfertility or infertility [ 82 ]. Several studies have shown that sperm survival and PMF integrity are negatively affected by the presence of various chemicals that disrupt membrane integrity resulting in higher ab [ 61 , 79 , 83 , 84 ]. The present study revealed a striking disparity in sperm morphology between the control and treatment cohorts.…”

“…The qPCR thermal cycle settings were as follow: A defatting cycle at 95 °C for 10 min, 45 three-step cycles each with 10 s defatting at 95 °C, 30 s compounding at 60 °C and the stretching step at 72 °C for 30 s. Gene expression in the samples was used to calculate relative expression using the following formula: Relative Expression = 2 - (SΔct-CΔct) , where SΔct is derived by subtracting ct of the reference gene from ct of the tested gene and the CΔct values ​​of ct are internal control samples. To generate the normal distribution of the relative expression values, these numbers were fitted by logarithm of 10 and then examined [ 61 ].…”

Ethno-botanical study of sedative medicinal plants in Shahrekord

“…Most of these plants have been used since ancient times with no report of side effects [37,38]. These plant not only have low side effects, but also may reduce the toxicity of other agents [39,41]. Therefore, they may have multiple beneficial effects.…”