Ginger- A Potential Source of Therapeutic and Pharmaceutical Compounds

Abstract

Ginger is traditionally known for its therapeutic and pharmaceutical properties. It has been used widely to treat various health problems such as high blood pressure, coughs, colds, swelling, nausea, rheumatic disorders, vomiting, bronchitis, indigestion, gastric ulcers, and behavioral problems. Shogaol and Gingerol are anti-inflammatory, anti-fever, anti-pain, and anti-cough compounds that may help treat a cold. This review provides an up-to-date understanding of the impact of ginger and its active compounds on human health. Various ginger compounds such as gingerol, shogaols, zingiberene, zingerone, paradols and zingerone are receiving attention for their clinical applications and pharmaceutical properties. Studies indicate that ginger is anti-inflammatory, anti-tumor, antimicrobial, antiemetic, hepatoprotective, and neuroprotective. During the inflammatory response, ginger inhibits (NF-κB) and immune system activation in addition to many other cellular processes. Ginger has shown benefits in preclinical and clinical studies for neurology, cardiovascular disease, and cancer. These findings indicate the necessity for further in vivo and clinical studies.

Molecular Docking of Zingerone and Gamma-Mangostin to Inhibit MAO-B and Catechol-O-Methyltransferase (COMT) in the Treatment of Parkinson’s Disease

“…Among the specific components of ginger are gingerol (in raw ginger, possibly responsible for the pungency) and its product zingerone (which gives dried or cooked ginger a sweet taste), Figure 2, named in his honor. Ginger also contains the enzyme zingibain, which regulates many processes in the plant by breaking down (Verma & Bisen, 2022) proteins. Source: Authors.…”

Ginger Extract as Potent Anti-Cancer Agent against Breast Cancer

“…Ginger (Zingiber officinale) has a long history of being used for medicinal and therapeutic purposes. Numerous health issues, including colds, swelling, high blood ulcers, diabetes, indigestion, and behavioral issues etc.. have all been treated with it as it has antiviral and antioxidant activity (Verma and Bisen 2022). These refer to the presence of compounds like gingerol, zingerone, shogaols, zingiberene, paradols, etc.,.…”

“…These refer to the presence of compounds like gingerol, zingerone, shogaols, zingiberene, paradols, etc.,. Gingerols are the key substances in several bioactivities among these phytocompounds (Babasheikhali et al, 2019 andVerma andBisen 2022).…”