Giant renal oncocytoma: a case report and review of the literature

Abstract

IntroductionRenal oncocytomas are benign neoplasms derived from cells of the distal renal tubule, and comprise 5% to 7% of primary renal neoplasms. Oncocytomas are mostly asymptomatic, and the majority of tumors are discovered incidentally. In this case report, we present a case of a patient with a giant oncocytoma arising from her left kidney.Case presentationWe describe a 25-year-old Turkish woman who was admitted to our hospital with abdominal pain and a 3-year palpable abdominal mass, which was found present since her second pregnancy. Examination revealed a 15 × 20-cm mass in her abdominal cavity. Computed tomography revealed a mass with regular outlines, measuring 18 × 11 × 12 cm, associated with the left kidney, and causing marked hydroureteronephrosis. We excised the mass and performed a left nephrectomy on our patient. The immunohistopathology of the mass was consistent with renal oncocytoma. No local or distant metastasis was seen at 6 months postoperatively.ConclusionTo the best of our knowledge, this is the second largest renal oncocytoma described in the English language literature. This is also the first reported giant oncocytoma that presented during pregnancy.

Differentiation of oncocytoma from chromophobe renal cell carcinoma (RCC): can novel molecular biomarkers help solve an old problem?

“…The locality and size of tumours may also be variable. Uncommonly, there have been case reports of large ROs (25×15×12 cm),27 but the average size is normally around 4.9±2.7 cm 28. Published reports worldwide show that ROs can be multifocal in 6–11%,29 30 and bilaterality was reported in about 3–5% 29 31.…”

Giant renal oncocytoma presenting with right flank pain and hematoma

“…Renal oncocytomas consist of pure oncocytes, which are polygonal cells with abundant mitochondria-rich eosinophilic cytoplasm arising from intercalated cells in the kidney. [5,7] [9] 1988 64 M 27 × 20 × 15 4,652 -Banks et al [10] 2001 57 M 21 × 18 × 15 3,090 -Kilic et al [2] 2003 65 M 20 × 15 × 10 2,680 -Sundararajan et al [4] 2008 37 M 20 3,353 Thoracoabdominal Sami Akbulut et al [7] 2010 25 F 25 × 16 × 12 3,380 Midline Safraz Ahmad et al [3] 2011 61 M 25 × 16 × 16 2,500 Right flank incision Albert El Hajj et al [6] 2014 45 M…”

Oncocitoma renal na gravidez – uma forma invulgar de hipertensão secundária

“…O oncocitoma renal representa cinco a sete por cento das neoplasias renais primárias cujo diagnóstico, feito maioritariamente em doentes assintomáticos, decorre da realização de exames complementares de diagnóstico por causas não-urológicas 1 . O oncocitoma renal é referido em termos anátomo-patológicos como uma massa sólida bem delimitada do parênquima renal com uma área de esclerose central; no entanto, é importante ressalvar que este aspecto classicamente descrito está presente apenas num terço dos casos 1---3 .…”