Giant proliferating trichilemmal malignant tumor

Extensive and ulcerated malignant proliferating trichilemmal (pilar) tumour, arising from multiple, large, degenerated trichilemmal (pilar) cysts

“…Lesions of the second and third group may require other interventions such as radiotherapy (in recurrence prophylaxis) or chemotherapy (for metastatic disease) 8 9 15. Nevertheless, the reduced number of cases described in the literature limits the efficacy evaluation of alternative treatments 3 6.…”

“…Nevertheless, the reduced number of cases described in the literature limits the efficacy evaluation of alternative treatments 3 6. Clinical follow-up is required subsequent to surgical intervention in order to monitor local recurrence and lymph node metastasis 6 15Learning points

Malignant proliferating pilar tumours are neoplasms of slow growth usually deriving from pre-existing trichilemmal cysts, and most likely caused by stimuli such as trauma and inflammation.

Histologically, this tumour mimics squamous cell carcinoma, creating a diagnostic challenge for pathologists, who should be watchful during histopathological examination of suspected cases.

The treatment of choice for malignant proliferating pilar tumours is wide-margin surgical excision, withholding chemotherapy and radiation therapy for cases in which metastatic disease and/or recurrence is present.

Clinicians and patients should be aware of the ability trichilemmal cysts have to develop malignancy and the ensuing consequences of neglecting them.

Public health bodies must be aware of the importance of providing social support to economically and socially disadvantaged patients.

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Malignant proliferating trichilemmal tumor: a rare neoplasm in a rarer location. Case report and review of the literature

“…The tumor usually appears on the scalp (>90% of cases), mostly affects women, occurring between the fourth and the eighth decade of life (16). Other rare site reported are the breast ( 17) arm (18), neck (19) jaw ( 20) sinuses ( 21) lip ( 22) eyelid ( 23) groin ( 24) orbit (25) and ear (26). Up to our knowledge this is the first case reported on the scrotum.…”

Malignant proliferating trichilemmal tumor in abdominal wall: Report of a rare case at an uncommon site with literature review

“…Furthermore, despite the general concepts, introduced above, different presentations have been reported for malignant PTT, such as presentation at early age 7 or giant tumor at an extraordinary site, back of the wrist. 8 Therefore, presenting the clinical experience of each case can help enrichment of the literature. In this paper, we present a male elderly with malignant PTT in his abdominal wall, a rare tumor site, which has been successfully treated with surgical excision.…”

“…Owing to the fact that cases with malignant PTT may be misclassified as other PTT types or other tumor types, such as squamous cell carcinoma (SCC), the exact incidence of malignant PTT is unknown, 3 but, generally fewer than 50 cases has been reported so far. Furthermore, despite the general concepts, introduced above, different presentations have been reported for malignant PTT, such as presentation at early age 7 or giant tumor at an extraordinary site, back of the wrist 8 …”