Giant Pilomatrix Carcinoma of the Face

Lohiya, Sapna; Rawal, Yeshwant B.; Dillon, Jasjit K.

doi:10.1016/j.joms.2017.08.010

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Due to its slow growth and rarity, it is often clinically misdiagnosed as a sebaceous cyst or other common skin tumor, potentially delaying tumor resection [5]. Limited biopsy may miss key histopathological features because of limited tissue sampling and make the diagnosis considerably challenging [6].…”

Section: Introductionmentioning

confidence: 99%

Case Report and Highlight Clues on the Diagnosis of Pilomatrical Carcinoma

Milagros

Alejandro

Gabriel

et al. 2021

Asp Biomed Clin Case Rep

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Pilomatrical Carcinoma (PC) is a rare malignant adnexal tumor with matrical differentiation. Its benign counterpart (Pilomatrixoma) is diagnosed much more frequently in daily pathological practice. Both entities share genetic alterations but the malignant counterpart acquires mutations that make it develop an aggressive behavior [1]. We describe a 33-year-old man who presented with a 7 x 6 cm nodular ulcerated lesion in the left ear with markedly accelerated growth in the last month. Incisional biopsy was referred to us with suspicion of squamous cell carcinoma versus pyogenic granuloma. Histologic sections showed ulcerated fragments infiltrated by a basaloid cell proliferation interspersed with groups of “ghost cells”. The neoplastic cells were arranged in irregular sheets with infiltrative borders. Groups of Squamous cells with trichilemmal keratinization and foci of necrosis were also identified. The biopsy was diagnosed as an adnexal neoplasm with pilomatrical differentiation, suggesting its complete resection with safety margins due to the presence of aggressive characteristics. The subsequent study of the excisional biopsy showed similar characteristics to those previously described. Notoriously, focal infiltration of the auricular cartilage was identified, leading us to the undoubted diagnosis of pilomatrical carcinoma.

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Section: Introductionmentioning

confidence: 99%

Case Report and Highlight Clues on the Diagnosis of Pilomatrical Carcinoma

Milagros

Alejandro

Gabriel

et al. 2021

Asp Biomed Clin Case Rep

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Pilomatrix Carcinoma: Report of Two Cases of the Head and Review of the Literature

et al. 2023

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Background: Pilomatrix carcinoma (PC) is a rare skin tumor arising from hair follicle matrix cells. It is locally aggressive with a high rate of local recurrence after surgical excision. Few cases in the literature have been described and the management is not well defined. Objectives: The aim of this study was to present two cases of PC located on the head and review the relevant literature about epidemiology, clinical and dermoscopic evaluation, characteristics of local and distant metastases, local recurrence rate and management of this rare skin tumor. Methods: We consulted databases from PubMed, Research Gate and Google Scholar, from January 2012 to November 2022. We reviewed the literature and reported two additional cases. Results: We selected 52 tumors in middle-aged to older patients located mostly on the head. Dermoscopy evaluation was rarely performed in the pre-operative diagnostic setting. The most definitive treatment was wide local excision, but local recurrences were common. In total, we observed 11 cases of recurrences and 9 patients with locoregional or distant metastases. Four patients received adjuvant radiotherapy, two patients needed chemotherapy and local cancer therapy and one patient received radiochemotherapy. Conclusions: Our reports and the review of the literature can provide a better awareness and management of this rare tumor.

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Giant Pilomatrix Carcinoma of the Face

Cited by 2 publications

References 8 publications

Case Report and Highlight Clues on the Diagnosis of Pilomatrical Carcinoma

Case Report and Highlight Clues on the Diagnosis of Pilomatrical Carcinoma

Pilomatrix Carcinoma: Report of Two Cases of the Head and Review of the Literature

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