Giant Pilomatricoma

Lozzi, Gian Piero; Soyer, H. Peter; Fruehauf, Julia; Massone, Cesare; Kerl, Helmut; Peris, Ketty

doi:10.1097/dad.0b013e318053db45

Cited by 39 publications

(40 citation statements)

References 18 publications

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“…The examination also showed extensive calcium deposits and multinucleated giant cells foreign-body type. 3 Kaddu et al 17 reported that the early PM fully developed can be distinguished by histopathologic analysis, demonstrating that there is a chronological evolution of the PM lesion from an infundibular matrix cyst to a calcified and ossified dermal nodule.…”

Section: Cells With Shadows Of Lost Nuclei and Clear Intercellular LImentioning

confidence: 99%

“…Pain and tenderness may be associated symptoms. 3,5 The tumor is generally observed on the head, neck and upper extremities. 6 It is a common skin neoplasm in the pediatric population, but it may be found in all age groups with bimodal peaks under the age of 30 and in the sixth/seventh decades of life.…”

Section: Introductionmentioning

confidence: 99%

“…In 1961, Forbis and Helwig demonstrated that the tumor originated from the hair matrix; therefore, the name pilomatrixoma. [1][2][3] PM is the most common hair-follicle tumor and it accounts for one of every 500 specimens submitted by dermatologists. 4 Clinically, the lesion is a benign cutaneous tumor usually characterized by a solitary asymptomatic, firm, and skin-colored faint blue/red nodule in the deep dermis and subcutaneous tissue, with an average size of 0.5 to 3.0 cm.…”

Section: Introductionmentioning

confidence: 99%

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An unusual presentation of giant pilomatrixoma in an adult patient

Souto

Matsushita²,

Matsushita³

et al. 2013

J Dermatol Case Rep

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Background: Pilomatrixoma (OMIM ID #132600) is a benign cutaneous tumor originating from the pilosebaceous follicle and characterized by the presence of subcutaneous nodules of up to 3.0 cm in diameter, usually on the head, neck and upper extremities. It is most common in the first two decades of life and after the age of 60.Main observations: An adult female patient was evaluated, presenting a solid tumoral lesion with erythematous surface and purplish tone, with approximately 7.5 x 5.0 cm in size, in the interscapulovertebral region. It was thought to be an epidermoid cyst, sarcoma, calcified hemangioma, giant dermatofibroma, or nodular basal cell carcinoma. The resection of the lesion was carried out and, at the histological examination, specific details were observed that led to the diagnosis of pilomatrixoma. Conclusion:Pilomatrixoma should be suspected in the differential diagnosis of giant adnexal tumors. (J Dermatol Case Rep. 2013; 7(2): 56-59) An unusual presentation of giant pilomatrixoma in an adult patient IntroductionPilomatrixoma (PM; OMIM ID #132600) was first described in 1880 by Malherbe and Chenatais as a "calcified epithelioma of Malherbe" originated from sebaceous glands. In 1961, Forbis and Helwig demonstrated that the tumor originated from the hair matrix; therefore, the name pilomatrixoma. 1-3 PM is the most common hair-follicle tumor and it accounts for one of every 500 specimens submitted by dermatologists. 4 Clinically, the lesion is a benign cutaneous tumor usually characterized by a solitary asymptomatic, firm, and skin-colored faint blue/red nodule in the deep dermis and subcutaneous tissue, with an average size of 0.5 to 3.0 cm. The lesions larger than 5.0 cm are defined as giant pilomatrixomas. Pain and tenderness may be associated symptoms. 3,5 The tumor is generally observed on the head, neck and upper extremities. 6 It is a common skin neoplasm in the pediatric population, but it may be found in all age groups with bimodal peaks under the age of 30 and in the sixth/seventh decades of life. 5,6 Uncommon clinical-pathological variants of PM have been reported, such as bullous like, anetodermic, exophytic, perforating/ulcerated and lymphagiectatic. Multiple and familial cases have been described in association with myotonic dystrophy, Turner's syndrome, Gardner's syndrome, xeroderma pigmentosum, basal cell nevus syndrome and Sotos syndrome. 6,7 The present paper reports an unusual and uncommon case of pilomatrixoma on the back of an adult female patient. Case ReportA 54-year-old female patient sought the medical specialties outpatient service at School of Medical Sciences at Universidade de Marília (UNIMAR) complaining about a back injury three years ago, with progressive growth and sporadic local pain. The patient had undergone a surgery for the removal of the lesion in another hospital two and a half years before, but there was local recurrence 3 months after surgery. Krausen et al. 9 described the first case of giant PM (GPM), few similar lesions were described 5 a...

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Section: Cells With Shadows Of Lost Nuclei and Clear Intercellular LImentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An unusual presentation of giant pilomatrixoma in an adult patient

Souto

Matsushita²,

Matsushita³

et al. 2013

J Dermatol Case Rep

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“…In the present case, the lesion was irregular and 7×5 cm in diameter with superficial hyperemia, clinically thought to be malignant. The lesions larger than 5 cm are generally defined as giant PMs [7]. To our knowledge, the largest reported PM in the literature was 24 cm in size and located in the upper back [8].…”

Section: Discussionmentioning

confidence: 95%

Giant gluteal pilomatrixoma: An uncommon tumor in a rare localization

Kılıç

Şen

2015

MMJ

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Pilomatrixoma is an uncommon, benign subcutaneous tumor arising from the hair follicle matrix. This tumor occurs more commonly in children than in adults, and most often originates on the head, neck or upper extremities. Gluteal region is an extremely rare site of pilomatrixoma. Multiple presentation is an unusual condition and often associated with some familial syndromes such as myotonic dystrophy, Gardner syndrome and Turner syndrome. Pilomatrixoma mostly presents as a painless, firm, slow-growing subcutaneous mass, and is usually encapsulated by connective tissue and sharply demarcated from the surrounding normal tissue. Both clinical and radiological findings are non-specific, and therefore histopathology is necessary to reach correct diagnosis. These lesions have very low risk of malignant transformation, and surgical excision with adequate margins is the treatment of choice. Herein, a rare case of gluteal pilomatrixoma with multiple presentation in the upper extremities in a young female patient was presented.

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“…Most pilomatricomas are solitary, firm, mobile, blue to red appearing, dermally based masses less than 1 cm in diameter, with giant tumours (diameter > 5 cm) reported infrequently in the literature (Kovacic et al, 2007;Lozzi et al, 2007;Piel et al, 2009). While generally benign lesions, pain and inflammation at the tumour site can heighten clinical suspicion for malignancy, and malignant transformation has been reported (Sasaki et al, 1976;Phyu and Bradley, 2001).…”

Section: Introductionmentioning

confidence: 93%