Background: Pilomatrixoma (OMIM ID #132600) is a benign cutaneous tumor originating from the pilosebaceous follicle and characterized by the presence of subcutaneous nodules of up to 3.0 cm in diameter, usually on the head, neck and upper extremities. It is most common in the first two decades of life and after the age of 60.Main observations: An adult female patient was evaluated, presenting a solid tumoral lesion with erythematous surface and purplish tone, with approximately 7.5 x 5.0 cm in size, in the interscapulovertebral region. It was thought to be an epidermoid cyst, sarcoma, calcified hemangioma, giant dermatofibroma, or nodular basal cell carcinoma. The resection of the lesion was carried out and, at the histological examination, specific details were observed that led to the diagnosis of pilomatrixoma. Conclusion:Pilomatrixoma should be suspected in the differential diagnosis of giant adnexal tumors. (J Dermatol Case Rep. 2013; 7(2): 56-59) An unusual presentation of giant pilomatrixoma in an adult patient IntroductionPilomatrixoma (PM; OMIM ID #132600) was first described in 1880 by Malherbe and Chenatais as a "calcified epithelioma of Malherbe" originated from sebaceous glands. In 1961, Forbis and Helwig demonstrated that the tumor originated from the hair matrix; therefore, the name pilomatrixoma. 1-3 PM is the most common hair-follicle tumor and it accounts for one of every 500 specimens submitted by dermatologists. 4 Clinically, the lesion is a benign cutaneous tumor usually characterized by a solitary asymptomatic, firm, and skin-colored faint blue/red nodule in the deep dermis and subcutaneous tissue, with an average size of 0.5 to 3.0 cm. The lesions larger than 5.0 cm are defined as giant pilomatrixomas. Pain and tenderness may be associated symptoms. 3,5 The tumor is generally observed on the head, neck and upper extremities. 6 It is a common skin neoplasm in the pediatric population, but it may be found in all age groups with bimodal peaks under the age of 30 and in the sixth/seventh decades of life. 5,6 Uncommon clinical-pathological variants of PM have been reported, such as bullous like, anetodermic, exophytic, perforating/ulcerated and lymphagiectatic. Multiple and familial cases have been described in association with myotonic dystrophy, Turner's syndrome, Gardner's syndrome, xeroderma pigmentosum, basal cell nevus syndrome and Sotos syndrome. 6,7 The present paper reports an unusual and uncommon case of pilomatrixoma on the back of an adult female patient. Case ReportA 54-year-old female patient sought the medical specialties outpatient service at School of Medical Sciences at Universidade de Marília (UNIMAR) complaining about a back injury three years ago, with progressive growth and sporadic local pain. The patient had undergone a surgery for the removal of the lesion in another hospital two and a half years before, but there was local recurrence 3 months after surgery. Krausen et al. 9 described the first case of giant PM (GPM), few similar lesions were described 5 a...

The injection of botulinum toxin A (BoNTA) is one of the most used cosmetic procedures for the treatment of dynamic facial wrinkles.The low rate of side effects and the great satisfaction of the patient with the results contribute to the increasing popularity of this procedure. 1 Botulinum toxin A is traditionally used on the upper third of the face to reduce wrinkles and improve eyebrow positioning. Currently, there is a tendency to apply BoNTA all over the face and neck, in order to improve facial contour, marionette lines and chin wrinkles.The anatomical complexity of the lower third of the face requires a more precise application of BoNTA and unexpected effects of migration of this toxin may occur. This paper reports a case of asymmetry

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Squamous cell carcinoma is the most common tumor in the hand, with actinic keratosis being its precursor lesion. It is a common tumor in light-skinned individuals with a history of excessive sun exposure and advanced age. It presents a wide variety of clinical forms, which can generate diagnostic doubt. The combination of clinical and pathological evaluations, together with detailed anamnesis, is the best way to achieve at the final diagnosis. The gold standard treatment for these tumors is surgical excision of the lesion with adequate safety margins; in some cases adjuvant radiotherapy is an excellent option. In this paper, we review the subject addressed and report the case of a patient with giant squamous cell carcinoma in one hand, with eight months of evolution, treated by surgical excision and adjuvant radiotherapy; the treatment was successful and preserved the motor function of the patient's hand.

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