Giant Median Raphe Cyst of the Penis with Diffuse Melanosis of Its Epithelial Lining

Abstract

Diffuse melanosis of the epithelial lining of an unusually large median raphe cyst of the penis is reported. Its light microscopic and ultrastructural features are described. The findings are discussed in the context of the published literature of genitourinary melanosis.

Pigmented Median Raphe Cysts of the Penis

“…However, median raphe cysts with melanosis are uncommon. Although the cause of pigmentation is not fully understood, this pigmentation may be due to the presence of lipochrome (4), the Tyndall phenomenon (5) or the presence of melanocytes (6). The distinctive feature in our cases was the presence of pigmentation in the lining of the cysts.…”

“…It was concluded that this pigment was due to the presence of melanocytes and melanophages based on the light and electron microscopic results. Hitti et al (6) reported the presence of melanocytes using electron and light microscopy.…”

Epidermoid cyst of the penis: A case report and review of the literature

“…4,8 To our knowledge, no cases of malignancy in cystic disease of the penis have been reported previously. [1][2][3][4][5][9][10][11][12][13][14][15][16][17][18][19] The indications for the treatment of cysts are secondary cystic infection, pain upon intercourse, cosmetic reasons, or obstruction of the urinary tract. Simple complete excision followed by primary closure has generally been regarded as the best treatment procedure.…”

“…[1][2][3][4][5][6][7][8] We report a pediatric case of epidermoid cyst of the penis, and review the etiology and outcome of penile cysts reported previously. [1][2][3][4][5][9][10][11][12][13][14][15][16][17][18][19] Furthermore, we discuss the nature of the disease and its appropriate management.…”

Pigmented median raphe cyst of the penis

“…3 It appears commonly in children or adolescents with a mean size of less than 20 mm. 4 Rarely, median raphe cyst contains melanin and melanocytes and clinically has a pigmented appearance. Such a cyst is called pigmented median raphe cyst.…”