Pigmented median raphe cyst of the penis

Nishida, Haruto; Kashima, Kenji; Daa, Tsutomu; Yada, Naomi; Arakane, Motoki; Matsuda, Kaho; Kato, Aiko; Shimizu, Fumiaki; Yokoyama, Shigeo

doi:10.1111/j.1600-0560.2011.01862.x

Cited by 9 publications

(10 citation statements)

References 14 publications

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“…The cyst wall of the median raphe cyst is lined by cuboidal to columnar cells, transitional (urothelial) cells, stratified squamous cells or a mixture of these (4). The presence of mucous and ciliated cells and decapitation secretion have also been previously reported (5).…”

Section: Discussionmentioning

confidence: 99%

“…The presence of mucous and ciliated cells and decapitation secretion have also been previously reported (5). Albeit rare, the presence of melanin pigment and/or melanocytes in median raphe cyst, namely pigmented median raphe cyst, has been documented (4). Previously, Nishida et al summarized the clinicopathological features of pigmented median raphe cyst (4).…”

Section: Discussionmentioning

confidence: 99%

“…Albeit rare, the presence of melanin pigment and/or melanocytes in median raphe cyst, namely pigmented median raphe cyst, has been documented (4). Previously, Nishida et al summarized the clinicopathological features of pigmented median raphe cyst (4). According to the analyses, the incidence of this variant is 2.1% and no clinicopathological differences have been identified between the pigmented and conventional cysts, with the exception of the presence or absence of melanin pigment and/or melanocytes (4).…”

Section: Discussionmentioning

confidence: 99%

“…Previously, a few hypotheses with regard to melanocytic colonization in non-melanocytic lesions have been proposed. For example, it has been suggested that the presence of melanocytes may be presented as heterotopic cell rests resulting from aberrant melanocytic migration during the embryonic period (4). It has also been hypothesized that the epithelial cells may produce factors that simulate the proliferation and differentiation of melanocytes, such as stem cell factor and endothelin-1 (11).…”

Section: Discussionmentioning

confidence: 99%

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Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

et al. 2013

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Median raphe cyst is a rare lesion located on the median raphe. The cyst wall is lined by cuboidal to columnar cells, transitional (urothelial) cells, stratified squamous cells or a mixture of these. The normal urethral mucosa and the median raphe cyst usually lack melanocytes and/or melanin pigment. However, albeit extremely rare, the presence of melanin pigment and/or melanocytes in median raphe cyst, namely pigmented median raphe cyst, has been previously reported. The current case report presents the sixth case of pigmented median raphe cyst and discusses the possible mechanism of melanocytic colonization in this tumor. A 48-year-old male presented with a nodule on the ventral surface of the penis. Histopathological study revealed that the cyst wall was covered by uniform bland cuboidal to urothelial cells. The peculiar observation was the presence of dendritic melanocytes among the epithelial cells. Therefore, a diagnosis of pigmented median raphe cyst was determined. Immunohistochemically, stem cell factor and endothelin-1 were not expressed in the epithelial cells of the cyst wall. It is well-known that melanocytes are rarely found in various non-melanocytic tumors, a phenomenon termed ‘colonization’. The mechanism by which melanocytes appear in median raphe cyst remains unclear. The present report is the first to demonstrate that melanocytic proliferation and differentiation factors, such as stem cell factor and endothelin-1, are not involved in the pigmentation of median raphe cyst. In addition, aberrant melanocytic migration may contribute to the development of this type of lesion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

et al. 2013

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“…MRCs are rare benign lesions of the male genitalia that can develop at any site along the midline from meatus to anus (i.e. parameatus, glans penis, penile shaft, scrotum, perineum, or perianal) 1–19 . The condition was first described by Mermet in 1895, 1 and MRC is currently believed to be caused by a defect in closure of the median raphe during embryonic development 19 .…”

Section: Introductionmentioning

confidence: 99%

Pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history

Kii

Taguchi²,

Nagahama

et al. 2021

IJU Case Reports

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Introduction Median raphe cysts are rare benign lesions of the male genitalia that can develop anywhere along the midline from meatus to anus. They are believed to be caused by a defect in closure of median raphe during embryonic development. These cysts commonly appear in childhood or adolescence, although some are diagnosed after middle age, typically triggered by infection or trauma. Pigmented median raphe cysts, or those containing melanin pigment and/or melanocytes, are extremely rare. Case presentation A 78‐year‐old man visited our hospital with a complaint of a penile mass that he first noticed in his 50s which slowly grew, eventually causing voiding difficulty. He had no history of infection or trauma. The lesion was excised, and the pathological diagnosis was pigmented median raphe cyst. Conclusion We successfully treated a rare case of pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history.

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Cutaneous Cysts

2018

Atlas of Dermatopathology

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Pigmented median raphe cyst of the penis

Cited by 9 publications

References 14 publications

Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

Pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history

Cutaneous Cysts

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