Giant congenital cellular blue naevus of the scalp with disseminated common blue naevi of the body

Serarslan, Gamze; Yaldız, Mehmet; Verdi, M

doi:10.1111/j.1468-3083.2008.02767.x

Cited by 10 publications

(9 citation statements)

References 12 publications

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“…3 To our knowledge, only 11 cases have been reported in the English-language and Japanese published work. [3][4][5][6][7][8][9][10][11][12][13] We reviewed those cases including our case (Table 1) and found the following characteristic features: all lesions except one 7 were solitary, asymptomatic and measured more than 5 cm diameter. Hair loss or sparse hair was rather common, noted in seven cases.…”

Section: Discussionmentioning

confidence: 99%

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Coexistence of giant blue nevus of the scalp with hair loss and alopecia areata

Takeichi

Kubo

Murao

et al. 2010

The Journal of Dermatology

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A 43-year-old Japanese man presented with a 13-year history of a grayish macule measuring 7 cm in diameter with sparse hairs on the vertex. Histopathological examination demonstrated two types of melanocytes, spindle-shaped and ovoid cells, with abundant melanin aggregated around the upper part of the pilosebaceous apparatus. Fibrous, thick collagen bundles were also seen surrounding the upper part of the small hair follicles. There was no infiltration of melanocytes or lymphocytes in the lower dermis or adipose tissue. Based on these findings, a diagnosis of blue nevus, cellular type, was made. Giant cellular blue nevi on the scalp are rare, and 11 cases reported in the published work have shown characteristic features such as hair loss and cranial invasion of nevus cells. It should be noted that melanocytes of giant blue nevi have a high potential to damage other organs such as underlying bone and hair follicles. The patient also showed a typical lesion of alopecia areata on the left temporal which was successfully treated with topical corticosteroid.

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Section: Discussionmentioning

confidence: 99%

“…Among these, the invasion reached the dura mater and brain through the cranial bone in four cases. [3][4][5][6][7][8][9][10][11][12][13][14] However, there were no neurological symptoms reported in these cases. Therefore, we took CT scans and found that there was no cranial invasion.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of giant blue nevus of the scalp with hair loss and alopecia areata

Takeichi

Kubo

Murao

et al. 2010

The Journal of Dermatology

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“…7). Zur Tiefe können sich die Nävuszellen dabei bis zum Periost, zur Kalotte und sogar zur Dura ausdehnen [23].…”

Section: Melanozytäre Näviunclassified

Fehlbildungen und Nävi des behaarten Kopfes

Behle

Hamm

2014

Hautarzt

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Unusual congenital or early-onset skin lesions on the scalp often pose a diagnostic challenge particularly as the clinical evaluation may be hampered by dense hair growth. Thus, this paper provides a concise review on developmental abnormalities and nevi with exclusive or predominant scalp localization. Aplasia cutis congenita occurs as an isolated finding, in association with genetic syndromes, nevi and anomalies or as a consequence of intrauterine trauma and teratogens. A hairless area with a narrow surrounding rim of hypertrichosis (hair collar sign) may point to occult cranial dysraphism, especially if accompanied by further suggestive signs as port-wine stains, large hemangiomas, dimples, congenital dermoid cysts, and sinuses. Many diverse entities may hide behind cutis verticis gyrata with the primary essential form being rare and representing a diagnosis of exclusion. In contrast to former belief, benign adnexal tumors arise in a nevus sebaceus considerably more often than basal cell carcinomas and other malignant epithelial tumors. Provided that tumor development is not suspected, excision of a nevus sebaceus nevus is indicated primarily for aesthetic-psychosocial reasons. However, surgical treatment is considerably easier in small children. Nevus sebaceus may be a cutaneous marker for several complex syndromes whereas nevus psiloliparus presents almost always in connection with encephalocraniocutaneous lipomatosis. Congenital melanocytic nevi of the scalp tend toward clinical regression, so that surgical intervention in large lesions should be carefully considered. In contrast, the threshold for excision of blue nevi and other conspicuous melanocytic nevi on the scalp should be low, especially since they are difficult to monitor.

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“…Stains were strongly positive for Melan‐A, HMB‐45, and CD‐117, and mostly negative for S‐100 and EMA. Clinical and laboratory data had suggested the diagnosis of GCCBN 1–4 . Repeat punch biopsies of nodular lesions over the bluish plaque had revealed histopathological stability without malignant transformation.…”

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confidence: 99%

“…GCCBN are clinically heterogeneous lesions frequently located on the scalp, 1 which can infiltrate soft tissues, bones, and dura mater. These rare lesions may be quiescent 2 or may undergo malignant transformation 3 and warrant early surgical excision 4 when possible.…”

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confidence: 99%