Giant cell tumour of tendon sheath: A 10‐year study from a tertiary care centre

Kumar, Rajesh; Bharani, Vani; Gupta, Nalini; Gupta, Kirti; Dey, Pranab; Srinivasan, Radhika; Rajwanshi, Arvind

doi:10.1111/cyt.12533

Cited by 8 publications

(33 citation statements)

References 9 publications

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“…Localized tenosynovial GCTs are commonly known as GCTTS and may arise in the association of tendon of small joints of hand and feet. Diffuse tenosynovial GCTs are commonly known as pigmented villonodular synovitis (PVS) arising outside the tendon, based in the synovium and are therefore generally intra‐articular in location 1,2,6 . In the present case series of 24 cases, we have studied the localized form of a tenosynovial GCT, termed commonly as GCTTS.…”

Section: Discussionmentioning

confidence: 99%

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FNAC study of giant cell tumor of tendon sheath (localized tenosynovial giant cell tumor): Clinico‐radiological correlation and cytopathological features

Aden

Khalid

Zaheer

et al. 2022

Diagnostic Cytopathology

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Background: Localized tenosynovial giant cell tumor (GCT) or giant cell tumor of tendon sheath (GCTTS), is a benign nodular lesion that arises from the synovium of the tendon sheath of the hands and foot. GCTTS is characterized by the presence of multinucleated giant cells and proliferation of synovial-like mononuclear cells. A clinical diagnosis of GCTTS is kept as a differential when a firm, nodular mass shows decreased signal intensity on both T1-and T2-weighted MR imaging. Treatment is usually marginal excision of the mass.Material and Methods: It is a retrospective study, observed in the past 3 years at a tertiary care hospital. Those cases were included in the study in which histopathological confirmation was available or if clinico-radiological features were confirmatory of the diagnosis of GCTTS when correlated with cytological features.Results: There was a total of 24 cases, out of which 16 were females and 8 males.The tumor was located in the upper limb in 21 cases and in 3 cases the tumor was present in the lower limb. In the upper limb, 18 cases were on the right side and three cases were on the left side. In the lower limb, 1 case was present on the left and 2 on the right side. The cytomorphology consisted of mononuclear stromal cells, multinucleated giant cells, and hemosiderin-laden macrophages in variable numbers. Conclusion:It is important to accurately diagnose and categorize giant cell-containing lesions because their prognosis depends on the exact categorization of the tumor.

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Section: Discussionmentioning

confidence: 99%

“…Giant cell tumor of tendon sheath (GCTTS) or localized tenosynovial giant cell tumor (GCT) is a localized form of nodular tenosynovitis. It is a slow‐growing benign tumor presenting as a nodule in soft tissue associated with tendon sheath or inter‐phalangeal joint 1,2 2 .…”

Section: Introductionmentioning

confidence: 99%

FNAC study of giant cell tumor of tendon sheath (localized tenosynovial giant cell tumor): Clinico‐radiological correlation and cytopathological features

Aden

Khalid

Zaheer

et al. 2022

Diagnostic Cytopathology

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“…75 Osteoclast-like giant cells are the most common type of giant cell seen, whereas Touton giant cells may also be seen to a lesser extent. 76 Although macrophages with lipid (xanthoma cells) or hemosiderin pigment (ladybird cells) may be seen (Fig. 3D), background inflammation is typically scant.…”

Section: Ganglioneuromamentioning

confidence: 99%

“…MGCs, which may be found scattered or near mononuclear cells, have a variable number of nuclei and blue to vacuolated cytoplasm (Figure 3C-E). 75 Osteoclast-like giant cells are the most common type of giant cell seen, whereas Touton giant cells may also be seen to a lesser extent 76. Although macrophages with lipid (xanthoma cells) or hemosiderin pigment (ladybird cells) may be seen (Fig.…”

Section: Giant Cell-rich Tumors Of Soft Tissuementioning

confidence: 99%

Approach to Fine Needle Aspiration of Giant Cell-rich Tumors of Soft Tissue

Rottmann

Pantanowitz

2022

Advances in Anatomic Pathology

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Giant cells may be found in a wide variety of reactive and neoplastic soft tissue lesions. Because of their distinct histomorphology, they often stand out in procured samples such as fine needle aspirates. The giant cells themselves may be benign or neoplastic. However, the presence, type, and quantity of giant cells are usually not specific and in some cases can even be misleading when making a diagnosis. The aim of this review is to guide the practicing cytopathologist in narrowing their differential diagnosis when encountering one of these challenging giant cell-rich lesions of the soft tissue.

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“…Soft tissue tumors of the hand in infants or children are generally rare. Differential diagnoses include giant cell tumors [2,10,11], vascular or lymphatic tumors [3], lipomas [15], embryonal rhab domyosarcomas [14] At the age of 5 months an open tumor biopsy was performed in general anesthesia, macroscopically revealing a fatty, somewhat jellylike mass surrounded by a dense capsule. The initial histology was not entirely conclusive, but not indicative for a malignant tumor.…”

Section: Introductionmentioning

confidence: 99%

Case report: Infant with a Fast-growing Soft Tissue Tumor on the Thumb, Revealing a PLAG1-positive Connatal Lipoblastoma

et al. 2020

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At the age of 4 months, an infant was presented to us with a nodular subcutaneous tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound. An MRI in sedation performed at the age of 4.5 months had no diagnostic specificity. By a biopsy at the age of 5 months malignancy could be excluded. Finally at the age of 16 months the tumor which had meanwhile grown to a monstrous size (5 cm of diameter) could be entirely removed by microsurgical technique maintaining the integrity of all intrinsic structures. The diagnosis of myxoid lipoblastoma was confirmed. According to literature, Lipoblastomas often present as connatal rapid growing soft tissue tumors and are benign. Total removal is essential for avoiding a local recurrence.

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Giant cell tumour of tendon sheath: A 10‐year study from a tertiary care centre

Cited by 8 publications

References 9 publications

FNAC study of giant cell tumor of tendon sheath (localized tenosynovial giant cell tumor): Clinico‐radiological correlation and cytopathological features

FNAC study of giant cell tumor of tendon sheath (localized tenosynovial giant cell tumor): Clinico‐radiological correlation and cytopathological features

Approach to Fine Needle Aspiration of Giant Cell-rich Tumors of Soft Tissue

Case report: Infant with a Fast-growing Soft Tissue Tumor on the Thumb, Revealing a PLAG1-positive Connatal Lipoblastoma

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