"Giant Cell Tumors" of the Mandible and Facial Bones

Giant Cell Tumor of the Larynx: A Clinicopathologic Series of Eight Cases and a Review of the Literature

“…Giant cell reparative granuloma and brown tumor of hyperparathyroidism are histologically similar to one another but differ from giant cell tumor (11,12,31). A clear-cut distinction is not always possible, but in general, giant cell tumor contains a more uniform distribution of larger giant cells with many more nuclei per cell (31).…”

“…A true GCT of bone should contain a large number of giant cells in a diffuse distribution (26). However, although the presence of giant cells can suggest a GCT, the diagnosis is made by a combination of the giant cells and the mononuclear cells of the stroma (31). These mononuclear cells are predominantly round, oval, or polygonal in shape and can resemble normal histiocytes (26,29).…”

“…A clear-cut distinction is not always possible, but in general, giant cell tumor contains a more uniform distribution of larger giant cells with many more nuclei per cell (31). In giant cell reparative granuloma, the giant cells tend to be aggregated, often around areas of hemorrhage, and giant cells with more than 20 nuclei are uncommon.…”

Huge Osteoclastoma of Hyoid Bone: A Case Report

“…Approximately 2 % of all GCTs arise in head and Neck region, with majority of them occurring in sphenoid, ethmoid and temporal bones [2,3]. They are rarely found in the neck and only 18 cases have been reported in laryngeal framework [4].…”

Orbital Involvement in Craniofacial Brown Tumors

“…[2][3][4][5][6][31][32][33][34][35][36][37][38][39][40][41] In 8 of these cases, the maxillary bone was compromised. 31,[33][34][35][36][37]39,40 Orbital invasion through lesions arising in the ethmoid or sphenoid sinuses 6,36,37,41,42 or frontal bone 2,4,5,32 have also been reported. These data indicate that the clinical findings of patient 13 are quite unusual because the orbit was invaded from the deep portion of the lateral wall, a location that has never been implicated as a source of brown tumors.…”