Giant cell tumor of the rib

Abstract

A 27-year-old woman with a giant cell tumor of the rib with a cystic-hemorrhagic appearance underwent surgery consisting of en bloc resection and reconstruction of the thoracic wall with Marlex mesh, reinforced with two titanium plates. When possible this type of tumor requires resection, instead of radiotherapy, since the majority of cases of malignant transformation are linked to prior radiation therapy.

Nonepiphyseal Giant Cell Tumor of the Rib: A Case Report

“…The posterior parts of the rib (head and tubercle) are most commonly affected, while involvement of the nonepiphyseal portions is very rare. Relatively, few case reports have been published with involvement of the anterior or middle part of the rib by GCT [4–8]. The studied tumors were generally large, with exophytic soft tissue component, causing a palpable lump or compressing and displacing adjacent organs (lung, liver, and breast).…”

“…Matrix calcification is rare. Nevertheless, peripheral calcifications, internal septa (which can also be calcified), and cystic components have been described [4–7]. Disruption of the cortex and extension in the soft tissues can also be appreciated.…”

“…Signal intensity is usually low or intermediate on T1W sequences and high on T2W sequences [9]. Inhomogeneous appearance is common, with signal voids (due to calcifications, hemosiderin, or vascular channels) and intensities indicative of hemorrhage at various stages [4, 7, 9]. Fluid-fluid levels are less common than in aneurysmal bone cyst [9].…”

Tumor de células gigantes costal ocupando todo o hemitórax

“…The open lung biopsy allowed the confirmation of the diagnosis of neoplasia, the elective treatment being radical tumor resection with free margins. (14) During surgery, it is essential that oncologic margins of distance from the tumor be maintained and that en bloc resection of the tumor and chest wall, including the ribs involved, be performed. The anatomopathological examination of the sample confirmed the free margins.…”

Giant Cell Tumour of the Anterior rib arc Masquerading as a Primary Breast Lump

“…The majority of patients with GCT will present with a lytic geographic lesion that destroys the involved bone [3], approximately 20 % are associated with a soft tissue component. Histologically, GCT shows a diffuse proliferation of multinucleated, osteoclast-like giant cells in a background of oval-to spindle-shaped mononuclear stromal cells [4]; the differential diagnosis includes brown tumours, telangiectatic osteosarcoma, malignant fibrous histiocytoma, chondroblastoma, and aneurysmal bone cysts.…”