Giant Cell Tumor of Tendon Sheath

Sapra, Sheetal; Prokopetz, Robert; Murray, Anthony W.

doi:10.1111/j.1365-4362.1989.tb02533.x

Cited by 11 publications

(6 citation statements)

References 12 publications

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“…The peak incidence noted in the third decade with a female preponderance, the frequent involvement of the index finger among the small digit tumors and the right knee joint in the large joint group, and X-ray findings in our study agree with similar observations made in other published series [1][2][3]5,8,11,12].…”

Section: Discussionsupporting

confidence: 92%

“…It was Jaffe and coworkers in 1941 [2] who regarded the synovium of the tendon sheath, bursa, and joint as an anatomical unit that could generate a family of lesions including the GCTTS (nodular tenosynovitis), localized and diffuse forms of pigmented villonodular synovitis, and extra-articular pigmented villonodular synovitis arising from bursae. Since then there have been reports about this lesion which further defined the entity [4][5][6][7][8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

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Giant cell tumor of the tendon sheath: A retrospective study of 28 cases

1998

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Background and Objectives: Giant cell tumor of the tendon sheath (GCTTS) is a lesion of uncertain etiology. To better interpret pathogenesis and aid in the differentiation of GCTTS from other similar pathological processes we reviewed the literature and analyzed the available information. Methods We retrospectively studied clinicopathologic findings in 28 cases of GCTTS on the basis of anatomic location and histologic appearance of the lesion. Results The GCTTS could be divided into those involving the common digits (20 cases) and larger joint group (8 cases) based on anatomic location. Grossly the digit tumors were small, multiple, surrounded by a thin fibrous capsule, and had a variegated appearance, while the large joint tumors were relatively large and covered by one or more layers of synovium. Microscopically both groups consisted of a mixture of round to polygonal histiocytes, foam cells, hemosiderin laden macrophages, and multinucleated giant cells. The giant cells seemed more abundant in the digit tumors, while the pseudoglandular spaces lined by synovial cells were more striking in the large joint group. Conclusions Local excision was the treatment of choice in the majority of the patients. Eight patients had local recurrence. J. Surg. Oncol. 1998;68:100–103. © 1998 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Giant cell tumor of the tendon sheath: A retrospective study of 28 cases

1998

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“…Nuclear grooves, convolutions and occasional intranuclear cytoplasmic inclusions are other findings of the stromal cells and have only recently been recognized in cytology. 2,8 These nuclear features were less frequently seen in the present cases compared to the previous report in which the authors found these features in all cases. 2 Other features such as foam cells, HLM and some inflammatory cells may also present with variable frequency and may mislead the pathologist in reaching a diagnosis of an inflammatory or reactive process.…”

Section: Discussioncontrasting

confidence: 56%

Cytomorphologic Spectrum of Giant Cell Tumor of Tendon Sheath

Batra

Jain²,

Singh³

et al. 2008

Acta Cytologica

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“…It can appear at any age; however, it is more frequent between 30 and 50 years of age [5, 6]. Synovial origin seems to be confirmed by positivity to immunohistological markers of the normal synoviocytes, although these markers are equally expressed by the cells of the monocyte-macrophagic system [7, 8, 9].…”

Section: Discussionmentioning

confidence: 99%

Postsurgical Paracicatricial Cutaneous Satellitosis of Giant Cell Tumour of the Tendon Sheath, Localized Type

Caputo¹,

Fiorella²,

Orlando

2011

Case Rep Dermatol

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Tenosynovial giant cell tumour (localized type) is a tumour of tendon sheaths and interphalangeal joints, affecting the digits and arising from the synovium. It is characterized by a proliferation of mononuclear cells and osteoclast-like polykaryocytes. Its propagation to the skin is an exceptional event, which can take place either in localized form in the fingertips (localized type) or in the rare diffuse form called giant cell tumour of the tendon sheath (diffuse type). We report here a case of giant cell tumour with cutaneous satellites, which appeared close to and around the surgical scar following the excision of the primary lesion, in a 9-year-old boy. In the cutaneous satellites, a few signs of transformation could be observed, consisting of the lack of stroma and pronounced cellularity characterized by sheets of rounded synovial-like cells admixed with multinucleated giant cells and xanthoma cells. No relapse was observed 1 year after a plastic surgery procedure (complete replacement of the involved skin). Diffuse lesions usually represent a diagnostic problem in comparison with their localized counterparts. The malignant transformation of an originally typical tenosynovial giant cell tumour is a rare but well-documented event. Our case seems to represent a typical example because the pronounced cellularity might wrongly lead to a diagnosis of malignancy.

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Giant Cell Tumor of Tendon Sheath

Cited by 11 publications

References 12 publications

Giant cell tumor of the tendon sheath: A retrospective study of 28 cases

Giant cell tumor of the tendon sheath: A retrospective study of 28 cases

Cytomorphologic Spectrum of Giant Cell Tumor of Tendon Sheath

Postsurgical Paracicatricial Cutaneous Satellitosis of Giant Cell Tumour of the Tendon Sheath, Localized Type

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