Cytomorphologic Spectrum of Giant Cell Tumor of Tendon Sheath

Batra, Vineeta Vijay; Jain, Shyama; Singh, Deepak Kumar; Kumar, Neeta

doi:10.1159/000325473

Cited by 15 publications

(23 citation statements)

References 10 publications

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“…The main characteristics are a population of spindle or polygonal mononuclear stromal cells mixed with multinucleated “osteoclast” type multinucleated cells, and little to no mitotic activity . Prominent cytologic findings often seen in human GCTTS and not seen in our case include the appearance of nuclear “grooves” and macrophages containing hemosiderin . In our case, the extra‐ and intracellular pink product, along with the botryose, floret, or rosette‐like nuclear arrangement of the multinucleated cells, appeared to be more prominent features compared with most human cytologic reports.…”

Section: Discussionmentioning

confidence: 45%

“…Cytologic descriptions of GCTTS in people are fairly consistent with the cytologic pattern in this case. The main characteristics are a population of spindle or polygonal mononuclear stromal cells mixed with multinucleated “osteoclast” type multinucleated cells, and little to no mitotic activity . Prominent cytologic findings often seen in human GCTTS and not seen in our case include the appearance of nuclear “grooves” and macrophages containing hemosiderin .…”

Section: Discussionmentioning

confidence: 55%

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Cytologic findings from a benign giant cell tumor of the tendon sheath in a dog

Campbell

Koehler

Weiss

et al. 2014

Veterinary Clinical Pathol

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A 6-year-old male neutered Australian Shepherd dog was presented for evaluation of a subcutaneous mass on the plantar aspect of the proximal left metatarsus. Fine-needle aspirate smears contained numerous plump spindle cells and large multinucleated cells amongst a considerable amount of pink extracellular matrix. Histopathologic diagnosis of the tissue obtained during initial biopsy and eventual surgical cytoreduction of the mass was a benign giant cell tumor of the tendon sheath (GCTTS). Immunohistochemically, the synovioblastic neoplastic cells were diffusely strongly positive for vimentin and S-100, were multifocally moderately positive for cytokeratin AE1/3, and were negative for CD18, muscle-specific actin (MSA), and melanoma-associated antigen (mutated) 1 (MUM-1). The dog recovered from surgery and underwent definitive radiation therapy to treat the local residual disease. Eight months later, the mass had not recurred. The diagnosis of GCTTS in this case supports previously published reports describing GCTTS as a relevant disease entity in dogs, and provides the first documentation of cytologic findings with this tumor. Further investigation is needed to correlate pathologic features with clinical behavior and response to therapy in dogs.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 55%

Cytologic findings from a benign giant cell tumor of the tendon sheath in a dog

Campbell

Koehler

Weiss

et al. 2014

Veterinary Clinical Pathol

View full text Add to dashboard Cite

show abstract

“…Earlier, many researchers described the cytomorphological details of TSGCTs and simultaneously correlated them with respective tissue sections. Somehow their cytomorphological diversities remained less recognized . In this presentation, we describe eight cytopathologically misdiagnosed cases of TSGCT, which were actually diagnosed with certainty on histopathology.…”

Section: Introductionmentioning

confidence: 90%

“…Somehow their cytomorphological diversities remained less recognized. [5][6][7] In this presentation, we describe eight cytopathologically misdiagnosed cases of TSGCT, which were actually diagnosed with certainty on histopathology. Hereinto, we discuss the reasons behind such miscued interpretations, and then propose certain steps to avoid the ultimate mismanagement.…”

Section: Introductionmentioning

confidence: 97%

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Pitfalls in the cytological diagnosis of tenosynovial giant cell tumor: An illustration of eight discordant cases

Mondal

Mandal

Khan

et al. 2017

Diagnostic Cytopathology

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Tenosynovial giant cell tumor (TSGCT) is a highly recurrent benign tumor of the extremities. Wide local excision is usually sufficient to achieve its recurrence-free outcome. However, that needs a confident pre-operative cytological diagnosis as TSGCT. Aspirates from this tumor express the characteristic polymorphic cytological pattern, enough to impose a definite diagnosis. However rarely so, inadequate sampling from smaller tumors or due to faulty techniques, and selective sampling from topographic clusters of any individual component may lead to wrong interpretation. An unorthodox location near the larger limb joints further complicates the diagnostic misery on occasions. Such tumors are amenable to incomplete removal and risk for future recurrence. In this report, we describe eight cases of TSGCTs that were cytologically diagnosed otherwise. The cytological features of these discrepant tumors and the factors attributable to such dilemma are elaborated. Finally, a possible remedy has been proposed at conclusion in order to avoid future inconveniences.

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Giant cell tumor of soft tissue: FNA cytopathology of 4 cases, review of the literature, and comparison with giant cell tumor of bone

Wakely

2021

Cancer Cytopathology

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Background The cytopathology of a giant cell tumor of soft tissue (GCT‐ST), a fibrohistiocytic neoplasm distinct from other giant cell–rich soft tissue tumors, is rarely reported. The authors report their experience with a series of 4 GCT‐ST fine‐needle aspiration (FNA) biopsy cases and compare them with a set from giant cell tumors of bone (GCTBs). Methods The authors' cytopathology files were searched for GCT‐ST examples with histopathologic confirmation. FNA biopsy smears were performed and examined with standard techniques. Results Four cases of GCT‐ST presenting as a primary soft tissue mass from 4 patients (3 males and 1 female; age range, 28‐75 years, mean age, 53 years) were retrieved. FNA sites included the anterior tibia, buttock, shoulder, and upper back. Three cases were interpreted as suspicious for sarcoma radiographically. The specific diagnoses were atypical giant cell tumor of tendon sheath, suspicious for GCT‐ST, atypical myxoid lesion with giant cells, and benign with osteoclast‐like giant cells (OLGCs). No case was interpreted as malignant. Aspirates consisted of mononuclear polygonal cells, spindled fibroblast cell clusters, and large OLGCs to the near exclusion of other cell types. OLGCs possessed 10 or more nuclei per cell. A comparison with GCTB aspirates and single case reports from the literature showed comparable cytomorphology. Conclusions GCT‐ST FNA smears mimic those of GCTBs containing a limited population of uniform spindle cell clusters, single dispersed polygonal cells, and cytologically banal OLGCs. GCT‐ST should be considered in the differential diagnosis of aspirates containing numerous osteoclast‐like giant cells.

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Cytomorphologic Spectrum of Giant Cell Tumor of Tendon Sheath

Cited by 15 publications

References 10 publications

Cytologic findings from a benign giant cell tumor of the tendon sheath in a dog

Cytologic findings from a benign giant cell tumor of the tendon sheath in a dog

Pitfalls in the cytological diagnosis of tenosynovial giant cell tumor: An illustration of eight discordant cases

Giant cell tumor of soft tissue: FNA cytopathology of 4 cases, review of the literature, and comparison with giant cell tumor of bone

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