Giant-Cell Reaction of Bone

D'alonzo, Richard T.; Pitcock, James A.; Milford, Lee W.

doi:10.2106/00004623-197254060-00017

Cited by 27 publications

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“…GCT has been reported in the distal extremities albeit rarely [2,4,10,14]. In these instances, the distinction between this neoplasm and GCRG could be difficult both radiologically [5,10,14] and histologically [2,4,5,10,14].…”

Section: Discussionmentioning

confidence: 99%

“…As stated above, the major differential diagnostic alternatives to GCRG of the small tubular bones of the hands and feet are GCT and AnBC [2,4,5,10,14]. GCT has been reported in the distal extremities albeit rarely [2,4,10,14].…”

Section: Discussionmentioning

confidence: 99%

“…Occasional additional reports, comprised of either single cases or small series have followed [4,5,6,7]. The largest studies were those by Wold et al [14], consisting of 30 cases; 27 of which were seen in consultation, and by Ratner and Dorfman [10] consisting of 20 cases diagnosed between 1966 and 1987, attesting to the relative rarity of GCRG in this site.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical and radiological features of GCRG are relatively nonspecific. Other lesions that may simulate it radiographically and histologically include the "brown tumours" of hyperparathyroidism [4,5,6,7,10], sarcomas that contain numerous osteoclast-like giant cells, GCT and AnBC [2, 4, 5, 10, 14]. Lesions of hyperparathyroid osteopathy may c o n - Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Outside this location, GCRG also has been described in the small tubular bones of the hands and feet [1,4,5,6,7,10,14], where it was initially called "giant cell reaction" [1]. Despite the reported extragnathic cases, this lesion continues to be under-recognized by many pathologists.…”

Section: Introductionmentioning

confidence: 99%

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Giant cell reparative granuloma of the distal skeletal bones

Panico

Passeretti

Rosa

et al. 1994

Vichows Archiv A Pathol Anat

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Giant cell reparative granuloma (GCRG) is a reactive bone lesion that most often involves the jaws. However, occasional cases of GCRG in the distal extremities have been reported, to which we add five cases. All the patients were young to middle-aged adults and had sharply bordered, lytic lesions. Histologically, all the lesions had areas of osteoclast-like giant cells and osteoblast mantled osteoid. Two of the cases had foci of osteoclast-like giant cells lining vascular spaces. In extragnathic locations, GCRG may simulate other osteolytic giant cells lesions such as giant cell tumour of bone and aneurysmal bone cyst (AnBC). Immunohistochemically, all cases showed positive staining of the stromal spindle cells for vimentin and actin, and of the osteoclast-like giant cells for CD68, vimentin and leucocyte common antigen. GCRG is a benign lesion and conservative therapy is curative. As GCRG may have histological features which resemble AnBC it may be considered to be the solid variant of AnBC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Giant cell reparative granuloma of the distal skeletal bones

Panico

Passeretti

Rosa

et al. 1994

Vichows Archiv A Pathol Anat

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“Solid” variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones. A study of its morphologic spectrum and distinction from allied giant cell lesions

Oda

Tsuneyoshi

Shinohara

1992

Cancer

101

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Background. Giant cell reparative granuloma is generally considered to be benign tumor‐like bone lesion. Its involvement of axial skeleton and long bones is rare. Methods. Seven cases of extragnathic giant cell reparative granuloma (GCRG), which arose in the axial skeleton and long bones, were analyzed clinicopathologically and compared with allied lesions consisting of 31 cases of aneurysmal bone cyst (ABC) and 83 cases of giant cell tumor of bone (GCT). Results. These occurred in patients ranging in age from 8‐36 years; two were in the vertebrae; two, in the clavicles; one, in rib; one, in the humerus; and one in the tibia. None of the patients with GCRG had recurrence despite incomplete resection. Its skeletal distribution and average associated patient age were similar to those of ABC. Histologically, they were characterized by florid fibroblastic proliferation with osteoclast‐like giant cell‐rich areas, stromal hemorrhage, and newly formed bone or osteoid trabeculae. The histologic features could be found around either the characteristic aneurysmal cysts or sinuses, although they were lacking any large blood‐filled spaces. Conclusions. The overlapping clinical and histologic features between GCRG and ABC and their similar biologic behavior represent related responses to an intraosseous hemorrhage. The authors prefer to use the term “solid variant of aneurysmal bone cyst” to describe this lesion.

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Giant-Cell Tumor (Osteoclastoma)

Schajowicz

1981

Tumors and Tumorlike Lesions of Bone and Joints

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Giant-Cell Reaction of Bone

Cited by 27 publications

References 0 publications

Giant cell reparative granuloma of the distal skeletal bones

Giant cell reparative granuloma of the distal skeletal bones

“Solid” variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones. A study of its morphologic spectrum and distinction from allied giant cell lesions

Giant-Cell Tumor (Osteoclastoma)

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