“Solid” variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones. A study of its morphologic spectrum and distinction from allied giant cell lesions

Oda, Yoshinao; Tsuneyoshi, Masazumi; Shinohara, Norio

doi:10.1002/1097-0142(19921201)70:11<2642::aid-cncr2820701113>3.0.co;2-#

Cited by 101 publications

(66 citation statements)

References 27 publications

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“…32 It has been suggested central giant cell reparative granuloma is a solid variant of aneurysmal bone cyst. 33,34 In this respect, it is noteworthy that the majority of aneurysmal bone cysts examined failed to express p63 suggesting they may be related tumors. However, the presence of p63 expression in some cases of aneurysmal bone cyst is as yet unexplained.…”

Section: Discussionmentioning

confidence: 90%

Giant cell tumor of bone express p63

Dickson

Wunder

et al. 2008

Modern Pathology

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p63 contributes to skeletal development and tumor formation; however, little is known regarding its activity in the context of bone and soft tissue neoplasms. The purpose of this study was to investigate p63 expression in giant cell tumor of bone and to determine whether it can be used to discriminate between other giant cell-rich tumors. Seventeen cases of giant cell tumor of bone were examined to determine the cell type expressing p63 and identify the isoforms present. Total RNA or cell protein was extracted from mononuclear-or giant cellenriched fractions or intact giant cell tumor of bone and examined by RT-PCR or western blot, respectively. Immunohistochemistry was used to evaluate p63 expression in paraffin embedded sections of giant cell tumor of bone and in tumors containing multinucleated giant cells, including: giant cell tumor of tendon sheath, pigmented villonodular synovitis, aneurysmal bone cyst, chondroblastoma, and central giant cell granuloma. The mononuclear cell component in all cases of giant cell tumor of bone was found to express all forms of TAp63 (a, b, and c), whereas only low levels of the TAp63 a and b isoforms were detected in multinucleated cells; DNp63 was not detected in these tumors. Western blot analysis identified p63 protein as being predominately localized to mononuclear cells compared to giant cells. This was confirmed by immunohistochemical staining of paraffin-embedded tumor sections, with expression identified in all cases of giant cell tumor of bone. Only a proportion of cases of aneurysmal bone cyst and chondroblastoma showed p63 immunoreactivity whereas it was not detected in central giant cell granuloma, giant cell tumor of tendon sheath, or pigmented villonodular synovitis. The differential expression of p63 in giant cell tumor of bone and central giant cell granuloma suggest that these two tumors may have a different pathogenesis. Moreover, p63 may be a useful biomarker to differentiate giant cell tumor of bone from central giant cell granuloma and other giant cell-rich tumors, such as giant cell tumor of tendon sheath and pigmented villonodular synovitis.

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Section: Discussionmentioning

confidence: 90%

Giant cell tumor of bone express p63

Dickson

Wunder

et al. 2008

Modern Pathology

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“…Giant cell tumors (GCT) are true expansile neoplasms, which erode the cortex and may extend beyond the bone into the soft tissues located mainly in the metaphyses of young adults [14,19]. In our case, GCT should be included in the differential diagnosis because of the presence of prominent osteoclast-type giant cells, however, the imaging characteristics would be atypical for this lesion.…”

Section: Discussion and Treatmentmentioning

confidence: 99%

“…Bone formation in a GCT rarely is present, as opposed to the case presented. Despite the fact that radiographically the lesion did not match a brown tumor (in hyperparathyroidism), this is mentioned because it is indistinguishable histologically from GCRG [9,14]. Chondroblastoma can be complicated with ABC and as much as 50% of the cases have stippled calcifications.…”

Section: Discussion and Treatmentmentioning

confidence: 99%

Orthopaedic · Radiology · Pathology Conference: Painful Ulnar Lesion in a 16-year-old Boy

Kontakis¹,

Karantanas²,

Papagelopoulos

2009

Clinical Orthopaedics &Amp; Related Research

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A 16-year-old boy presented with swelling and a firm painful mass located in the middle of his right forearm 5 weeks after a fall from his bicycle. Immediately after this fall, he had experienced pain, and a contusion of his right forearm was diagnosed in the local emergency department. Gradually, the forearm swelling increased. The pain was mild and did not interrupt sleep. The patient was referred for a second evaluation 3 weeks later in a local public health center. A radiographic assessment of his right forearm (Fig. 1) was performed and the radiographs were erroneously interpreted as normal by a general practitioner, who advised rest.Five weeks postinjury, the symptoms continued and the swelling increased. Physical examination in our hospital revealed a firm mass in his middle forearm, predominantly in the ulnar side, over an area approximately 7 9 7 cm. There was tenderness to palpation and the overlying skin was apparently normal. He was not febrile, had no palpable lymph nodes, and had full motion in the neighboring joints.

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“…When occurring in the mandible, maxilla, hands, or feet, S-ABC may be referred to as "giant cell reparative granuloma" [4,5,7].…”

mentioning

confidence: 99%

“…S-ABC demonstrates a narrow zone of transition with marginal sclerosis, which may be complete in more than half of cases [1,2,4,7,8]. In long bones, S-ABC is often eccentric and most commonly involves the metaphysis.…”

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confidence: 99%