Abstract:A case of primary malignant fibrous histiocytoma of the breast is reported. The patient was a 48-yr-old woman with a huge tumor involving almost the entire left breast. The central portion of her left breast was already rotted by extensive necrosis and inflammation. She was treated by radical mastectomy and axillary lymphadenectomy to level I. Pathologic examination supported by an immunohistochemical staining confirmed the tumor as malignant fibrous histiocytoma of giant cell type. Axillary lymph nodes were f… Show more
“…Al analizar los casos reportados en la literatura (Tabla 1), los cuales poseen diagnóstico inmunohistoquímico confirmatorio [9][10][11][12][13][14][15][16][17][18][19] , los sarcomas pleomórficos de la mama se presentan clínicamente como una masa unilateral de consistencia firme y márgenes bien definidos a la palpación; se distinguen clínicamente de los carcinomas mamarios por su rápido patrón de crecimiento, y porque que a pesar de su gran tamaño, no existe relación entre este y el compromiso de ganglios, lo cual es fundamental al momento de establecer un diagnóstico diferencial 20 .…”
giant pleomorphic breast sarcoma It is reported the case of a female patient 50 years old who, after failed attempts at diagnosis, arrives at breast surgery service of the E.S.E. Hospital Universitario del Caribe with history of five months consistent in the excessive growth of a mass in right breast; patient received radical mastectomy plus reconstruction with latissimus dorsi muscle flap. Following excision of tumor mass of 6,500 g is performed immunohistochemical diagnosis of a giant pleomorphic sarcoma.
“…Al analizar los casos reportados en la literatura (Tabla 1), los cuales poseen diagnóstico inmunohistoquímico confirmatorio [9][10][11][12][13][14][15][16][17][18][19] , los sarcomas pleomórficos de la mama se presentan clínicamente como una masa unilateral de consistencia firme y márgenes bien definidos a la palpación; se distinguen clínicamente de los carcinomas mamarios por su rápido patrón de crecimiento, y porque que a pesar de su gran tamaño, no existe relación entre este y el compromiso de ganglios, lo cual es fundamental al momento de establecer un diagnóstico diferencial 20 .…”
giant pleomorphic breast sarcoma It is reported the case of a female patient 50 years old who, after failed attempts at diagnosis, arrives at breast surgery service of the E.S.E. Hospital Universitario del Caribe with history of five months consistent in the excessive growth of a mass in right breast; patient received radical mastectomy plus reconstruction with latissimus dorsi muscle flap. Following excision of tumor mass of 6,500 g is performed immunohistochemical diagnosis of a giant pleomorphic sarcoma.
“…There was also semicircular canal invasion of the tumor on MRI before the first surgery. According to previous reports, there have been some cases of parenchymal invasion of GCTs with malignant pathologic findings [ 19 23 ]. Despite generally being benign, the natural history of GCTs is locally aggressive, and they recur at a high rate (10–20%) [ 24 ].…”
Giant cell tumors are benign but locally invasive and frequently recur. Giant cell tumors of the skull are extremely rare. A patient underwent a surgery to remove a tumor, but the tumor recurred. Additionally, the patient developed multiple aneurysms. The patient underwent total tumor resection and trapping for the aneurysms, followed by radiotherapy. We report this rare case and suggest some possibilities for treating tumor growth combined with aneurysm development.
“…Many breast sarcomas, and especially angiosarcoma, arise frequently after radiotherapy [ 3 ]. Malignant fibrous histiocytomas may also develop in the breast after radiation therapy for breast carcinoma [ 13 ], while many reported cases seem to appear de novo [ 2 , 7 – 12 ].…”
This paper concerns a case of Malignant Fibrous Histiocytoma (MFH) of the Breast in a 73-years-old woman. A lump was found in her right breast, measuring 1.7 cm in diameter. Surgical excision followed, and pathology revealed a highly atypical spindle cell tumor. Immunohistochemistry along the histological features, excluded the possibility of carcinoma, malignant phyllodes tumor, or another type of pure sarcoma. There was no history of previous irradiation in the region. MFH is among the rarest types of sarcoma of the breast, and most of the times behaves aggressively. Excision with wide, free-of-tumor margins is the most effective treatment, when feasible.
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