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2004
DOI: 10.3346/jkms.2004.19.3.477
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Giant Cell Malignant Fibrous Histiocytoma of the Breast: A Case Report

Abstract: A case of primary malignant fibrous histiocytoma of the breast is reported. The patient was a 48-yr-old woman with a huge tumor involving almost the entire left breast. The central portion of her left breast was already rotted by extensive necrosis and inflammation. She was treated by radical mastectomy and axillary lymphadenectomy to level I. Pathologic examination supported by an immunohistochemical staining confirmed the tumor as malignant fibrous histiocytoma of giant cell type. Axillary lymph nodes were f… Show more

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Cited by 12 publications
(4 citation statements)
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“…Al analizar los casos reportados en la literatura (Tabla 1), los cuales poseen diagnóstico inmunohistoquímico confirmatorio [9][10][11][12][13][14][15][16][17][18][19] , los sarcomas pleomórficos de la mama se presentan clínicamente como una masa unilateral de consistencia firme y márgenes bien definidos a la palpación; se distinguen clínicamente de los carcinomas mamarios por su rápido patrón de crecimiento, y porque que a pesar de su gran tamaño, no existe relación entre este y el compromiso de ganglios, lo cual es fundamental al momento de establecer un diagnóstico diferencial 20 .…”
Section: Discussionunclassified
“…Al analizar los casos reportados en la literatura (Tabla 1), los cuales poseen diagnóstico inmunohistoquímico confirmatorio [9][10][11][12][13][14][15][16][17][18][19] , los sarcomas pleomórficos de la mama se presentan clínicamente como una masa unilateral de consistencia firme y márgenes bien definidos a la palpación; se distinguen clínicamente de los carcinomas mamarios por su rápido patrón de crecimiento, y porque que a pesar de su gran tamaño, no existe relación entre este y el compromiso de ganglios, lo cual es fundamental al momento de establecer un diagnóstico diferencial 20 .…”
Section: Discussionunclassified
“…There was also semicircular canal invasion of the tumor on MRI before the first surgery. According to previous reports, there have been some cases of parenchymal invasion of GCTs with malignant pathologic findings [ 19 23 ]. Despite generally being benign, the natural history of GCTs is locally aggressive, and they recur at a high rate (10–20%) [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…Many breast sarcomas, and especially angiosarcoma, arise frequently after radiotherapy [ 3 ]. Malignant fibrous histiocytomas may also develop in the breast after radiation therapy for breast carcinoma [ 13 ], while many reported cases seem to appear de novo [ 2 , 7 12 ].…”
Section: Discussionmentioning
confidence: 99%