Giant basal cell carcinoma with regional lymph node and distant lung metastasis

Aldhaban, Saud; Marc, Siham; Eshki, Majed; Girod, Angélique; Boissonet, Hervé; Chapelier, Alain; Carlotti, A.; Sastre-Garau, Xavier; Athanasiou, A.; Zemoura, L.; Bolle, Stéphanie; Wallach, Daniel; Avril, Marie-Françoise

doi:10.1684/ejd.2011.1519

Cited by 13 publications

(29 citation statements)

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“…Lesions 5 and 10 cm have metastatic rates of 25% and 50%, respectively. 6,9 Finally, the depth of invasion 10 and the histologic subtype 1 also correlate to metastatic rates. Morpheaform, metatypical (basosquamous carcinoma), infiltrative, and adenocystic variants of BCC are believed to be more aggressive and locally invasive, 7 although this is still debated.…”

Section: Discussionmentioning

confidence: 99%

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Bilateral Lymphatic Spread of Metastatic Basal Cell Carcinoma

Willcockson

Watley

Durden

et al. 2016

Plastic and Reconstructive Surgery - Global Open

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Summary:Herein, we report a case of a patient with an abnormal skin lesion that remained unchecked by medical professionals for approximately 20 years. Upon physical examination in the emergency department for a fractured hip, an infiltrative mass was incidentally discovered. The neoplasm was noted to have progressed from an eraser-sized mass to a 3.5-cm invasive lesion. Initial surgical intervention was believed to have been successful in removal, as margins were clear with the exception of 1 indeterminate segment. However, subsequent 1-year follow-up revealed recurrence of the disease with bilateral axillary node and deep muscle involvement. This prompted a more extensive surgical approach complemented with radiation therapy. The patient had remained disease-free for a year.

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Section: Discussionmentioning

confidence: 99%

“…Morpheaform, metatypical (basosquamous carcinoma), infiltrative, and adenocystic variants of BCC are believed to be more aggressive and locally invasive, 7 although this is still debated. 2,4,9,10 …”

Section: Discussionmentioning

confidence: 99%

Bilateral Lymphatic Spread of Metastatic Basal Cell Carcinoma

Willcockson

Watley

Durden

et al. 2016

Plastic and Reconstructive Surgery - Global Open

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“…1,2,4,6-8 They are diagnosed on the seventh decade of life, with an average age of 67.7 years in men and 68.6 years in women. 3,4,9 GBCCs as a group share some epidemiologic characteristics as being multiple tumors that occur on areas of the skin that are not exposed to the sunlight (back, shoulders, legs, buttocks) and the absence of known risk factors as arsenic, tar, or radiation exposure. 8 Most patients with GBCC present with a prolonged clinical course associated to a delay in seeking medical attention and mental illness.…”

Section: Review Definitionmentioning

confidence: 99%

“…2,4 They are more frequently observed in men (2:1), 2,4 although some series report that these tumors occur most often in women (4:1). 3,4,9 Smoking is associated to a higher prevalence of BCC greater than 1 cm in their largest diameter; an epidemiological study reported that 50% of the patients with GBCC were smokers. 3,4,9 GBCCs as a group share some epidemiologic characteristics as being multiple tumors that occur on areas of the skin that are not exposed to the sunlight (back, shoulders, legs, buttocks) and the absence of known risk factors as arsenic, tar, or radiation exposure.…”

Section: Review Definitionmentioning

confidence: 99%

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Giant Basal Cell Carcinoma

Jiménez-Hernández¹,

Caballero-Centeno

Barrera-Pérez

et al. 2016

The American Journal of Dermatopathology

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Giant basal cell carcinomas (GBCCs) are a strange and aggressive variety of basal cell carcinomas (BCCs); they are characterized by deep tissue invasion, rapid growth, high risk of metastasis, and a poor prognosis. GBCCs represent 0.4%-1% of all BCCs. The pathogenesis of GBCC is sometimes linked to a spontaneous mutation in the PTCH gene, mapped to the q22.33 locus of chromosome 9. The key factor in the development of GBCC, in at least 30% of the cases, is the delay in seeking medical attention (7.5 ± 3.1 years). This is associated to a poor socioeconomic level, deficient hygiene, mental illness, advanced age, and the fact that BCCs are painless lesions. The authors present a Mexican female with a 2-year ulcer diagnosed as a GBCC in the year 2000, its initial therapeutic approach, and her follow-up during the next 12 years.

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