Ghrelin Suppresses Secretion of Luteinizing Hormone in Humans

Kluge, Michael; Schüssler, P.; Uhr, Manfred; Yassouridis, Alexander; Steiger, Axel

doi:10.1210/jc.2007-0593

Cited by 129 publications

(98 citation statements)

References 31 publications

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“…Specifically, AG administration was shown to inhibit LH release in rats (Furuta et al 2001, Fernandez-Fernandez et al 2005, and FSH and LH in healthy men (Kluge et al 2007, Lanfranco et al 2008, Kluge et al 2009) and women (Messini et al 2010a, Kluge et al 2012. On the other hand, the role of AG on TSH release is not well defined as some studies indicate a lack of direct effect on TSH release in humans (Takaya et al 2000, Hataya et al 2001, Nagaya et al 2001, while a recent study indicates that AG administration could induce a decrease in TSH release in healthy subjects (Kluge et al 2010).…”

Section: Observations)mentioning

confidence: 99%

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Gahete

Rincón-Fernández

Villa-Osaba

et al. 2013

Journal of Endocrinology

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Ghrelin is a 28-amino acid acylated hormone, highly expressed in the stomach, which binds to its cognate receptor (GHSR1a) to regulate a plethora of relevant biological processes, including food intake, energy balance, hormonal secretions, learning, inflammation, etc. However, ghrelin is, in fact, the most notorious component of a complex, intricate regulatory system comprised of a growing number of alternative peptides (e.g. obestatin, unacylated ghrelin, and In1-ghrelin, etc.), known (GHSRs) and, necessarily unknown receptors, as well as modifying enzymes (e.g. ghrelin-O-acyl-transferase), which interact among them as well as with other regulatory systems in order to tightly modulate key (patho)-physiological processes. This multiplicity of functions and versatility of the ghrelin system arise from a dual, genetic and functional, complexity. Importantly, a growing body of evidence suggests that dysregulation in some of the components of the ghrelin system can lead to or influence the development and/or progression of highly concerning pathologies such as endocrine-related tumors, inflammatory/cardiovascular diseases, and neurodegeneration, wherein these altered components could be used as diagnostic, prognostic, or therapeutic targets. In this context, the aim of this review is to integrate and comprehensively analyze the multiple components and functions of the ghrelin system described to date in order to define and understand its biological and (patho)-physiological significance.

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Section: Observations)mentioning

confidence: 99%

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Gahete

Rincón-Fernández

Villa-Osaba

et al. 2013

Journal of Endocrinology

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“…Since its initial description in 1999 [125], a variety of new functions for ghrelin have been characterized in the literature. Thus, apart from its GHreleasing and orexigenic effects, ghrelin has been reported to influence sleep and behaviour [127,128], and the pituitary-gonadal axis at both peripheral [129] and central levels [130,131].…”

Section: Ghrelinmentioning

confidence: 99%

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Fernández-Santos¹,

García-Marín²,

Utrilla³

et al. 2012

Thyroid Hormone

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“…Furthermore the interval between this and the preceeding peak was significantly longer after ghrelin than after placebo. Significantly more LH pulses occurred after placebo than after ghrelin administration (Kluge et al, 2007a). In all, ghrelin caused both a delay and suppression of the amplitude of LH pulses.…”

Section: -Please Insert Figures 1 and 2 Near To Here -mentioning

confidence: 74%