Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ

Inui, Akio; Asakawa, Akihiro; Bowers, Cyril Y.; Mantovani, Giovanni; Laviano, Alessandro; Meguid, Michael M.; Fujimiya, Mineko

doi:10.1096/fj.03-0641rev

Cited by 366 publications

(244 citation statements)

References 274 publications

(339 reference statements)

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“…97,98 It is the only potent orexigenic peptide found in circulation. Ghrelin cognate receptor is the G protein-coupled growth hormone secretagogue receptor.…”

Section: Ghrelinmentioning

confidence: 99%

Taste perception, associated hormonal modulation, and nutrient intake

et al. 2015

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It is well known that taste perception influences food intake. After ingestion, gustatory receptors relay sensory signals to the brain, which segregates, evaluates, and distinguishes the stimuli, leading to the experience known as "flavor." It is well accepted that five taste qualities -sweet, salty, bitter, sour, and umami -can be perceived by animals. In this review, the anatomy and physiology of human taste buds, the hormonal modulation of taste function, the importance of genetic chemosensory variation, and the influence of gustatory functioning on macronutrient selection and eating behavior are discussed. Individual genotypic variation results in specific phenotypes of food preference and nutrient intake. Understanding the role of taste in food selection and ingestive behavior is important for expanding our understanding of the factors involved in body weight maintenance and the risk of chronic diseases including obesity, atherosclerosis, cancer, diabetes, liver disease, and hypertension.

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“…97,98 It is the only potent orexigenic peptide found in circulation. Ghrelin cognate receptor is the G protein-coupled growth hormone secretagogue receptor.…”

Section: Ghrelinmentioning

confidence: 99%

Taste perception, associated hormonal modulation, and nutrient intake

et al. 2015

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“…In addition, we looked for changes in expression of the gastric motility stimulant motilin (Sanger 2008) and the receptors for ghrelin. The latter was included because of an association between ghrelin and changes in appetite and gastric motility (Inui et al 2004) and also because of a previous study in rats, which showed that the ghrelin receptor may be up-regulated following administration of cisplatin (Malik et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of neo-adjuvant chemotherapy for oesophago-gastric cancer on neuro-muscular gastric function

Sung

Arasaradnam

Jarvie³

et al. 2012

Mol Biol Rep

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“…2 Ghrelin stimulates food intake in both rodents and humans, 2,3 and is strongly involved in the regulation of energy homeostasis. 4 This suggests that derangement in the ghrelin system could play a role in obesity. In addition, ghrelin may affect carbohydrate and lipid metabolisms.…”

Section: Introductionmentioning

confidence: 99%

Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort

Kuzuya

Ando²,

Iguchi

et al. 2006

Int J Obes

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Objective: To investigate whether Leu72Met polymorphism of the preproghrelin gene is associated with overweight/obesity in middle-aged and older Japanese. Design: Cross-sectional analysis. Subjects: A total of 2238 community-dwelling middle-aged and older Japanese people (age: 40-79 years) who participated in the first wave of examinations in the National Institute for Longevity Sciences -Longitudinal Study of Aging from April 1998 to March 2000. Measurements: The Leu72Met polymorphism of prepoghrelin gene, anthropometric variables including body weight, body mass index (BMI), waist circumference, waist-to-hip ratio and whole-fat mass and biochemical variables including serum lipid levels, fasting plasma glucose, insulin and homeostasis model assessment for insulin resistance. Results: The frequencies of the Leu72Leu, Leu72Met and Met72Met alleles were 63.4, 32.7 and 4.0%, respectively. No differences in the genotype distributions of the Leu72Met polymorphism were found between genders or age groups, and no significant associations were observed between polymorphism and anthropometric variables in women and older men. However, middle-aged men who were 72Met allele carriers showed a higher body weight change from body weight at 18 years of age, as well as a higher waist circumference and a tendency to a higher waist-hip-ratio than noncarriers. Although there were no significant differences in the genotype distribution according to BMI in women and older men, a significantly higher frequency of the 72Met allele was found in the higher BMI group (BMIX25 kg/m 2 ) of middle-aged men than in the normalweight group. No significant associations were observed between polymorphism and serum lipid, glucose or insulin levels. Conclusions: These results suggest that the 72Met allele of the preproghrelin gene is a contributing factor for midlife weight change in men.

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Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ

Cited by 366 publications

References 274 publications

Taste perception, associated hormonal modulation, and nutrient intake

Taste perception, associated hormonal modulation, and nutrient intake

Effects of neo-adjuvant chemotherapy for oesophago-gastric cancer on neuro-muscular gastric function

Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort

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