Ghrelin: A multifunctional hormone in non-mammalian vertebrates

Kaiya, Hiroyuki; Miyazato, Minoru; Kangawa, Kenji; Peter, Richard; Unniappan, Suraj

doi:10.1016/j.cbpa.2007.12.004

Cited by 214 publications

(129 citation statements)

References 150 publications

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“…The GHS-R1a of grass carp shared 97% amino acid identity with zebrafish, 96% with jian carp and 93% with goldfish. Amino acid sequences of GHS-R1a of seabream, pufferfish and chicken GHS-R1a have 56, 55 and 72% identity to human GHS-R1a, respectively (Palyha et al, 2000;Kaiya et al, 2008;Zhang et al, 2008). It has been reported that the GHS-R gene has two exons and one intron in chicken (Tanaka et al, 2003), seabream (Chan and Cheng, 2004) and pufferfish (Palyha et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus

Cai

Yuan

et al. 2015

Comparative Biochemistry and Physiology Part A: Molecular &

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Section: Discussionmentioning

confidence: 99%

Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus

Cai

Yuan

et al. 2015

Comparative Biochemistry and Physiology Part A: Molecular &

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“…Besides the role of GHRL in food intake regulation, this hormone has been also involved in the control of glucose and lipid homeostasis and metabolism (Sangiao-Alvarellos et al 2010, Ratner et al 2015 and modulation of hormone release (Carreira et al 2013), among others (Sato et al 2014, Müller et al 2015. GHRL has been also identified in a number of fish species, including rainbow trout (Oncorhynchus mykiss), Japanese eel (Anguilla japonica), sea bass (Dicentrarchus labrax), Atlantic salmon (Salmo salar), zebrafish (Danio rerio), goldfish (Carassius auratus), tilapia (Oreochromis mossambicus) and channel catfish (Ictalurus punctatus) (Kaiya et al 2008, Kang et al 2011. It is highly expressed in the gastrointestinal tract, moderately in the brain and to a lower extent in other tissues (Unniappan et al 2002, Volkoff et al 2005.…”

Section: Introductionmentioning

confidence: 99%

“…Once octanoylated, GHRL binds to GHS-R1a, which is also expressed in a panel of fish tissues such as the brain (particularly hypothalamus), gastrointestinal tissue, pancreatic cells and liver (Chang & Cheng 2004, Kaiya et al 2009, Cruz et al 2010. The role of GHRL in fish is far from elucidated though it has been involved in the control of food intake (Unniappan et al 2002, Kang et al 2011, Jönsson 2013), glucose and lipid metabolism (Kaiya et al 2009, Salmeró n et al 2015 and the modulation of growth hormone and prolactin release (Kaiya et al 2008). GHRL is accepted as an orexigenic factor in fish (Unniappan et al 2002, Shepherd et al 2007, Tinoco et al 2014, though changes in the expression of neuropeptides involved in the metabolic regulation of food intake have been scarcely studied (Polakof et al 2011a, Riley 2013, Tinoco et al 2014, Schroeter et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout

Velasco¹,

Librán-Pérez²,

Otero-Rodiño³

et al. 2015

Journal of Endocrinology

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There is no information available on fish as far as the possible effects of ghrelin on hypothalamic fatty acid metabolism and the response of fatty acid-sensing systems, which are involved in the control of food intake. Therefore, we assessed in rainbow trout the response of food intake, hypothalamic fatty acid-sensing mechanisms and expression of neuropeptides involved in the control of food intake to the central treatment of ghrelin in the presence or absence of a long-chain fatty acid such as oleate. We observed that the orexigenic actions of ghrelin in rainbow trout are associated with changes in fatty acid metabolism in the hypothalamus and an inhibition of fatty acid-sensing mechanisms, which ultimately lead to changes in the expression of anorexigenic and orexigenic peptides resulting in increased orexigenic potential and food intake. Moreover, the response to increased levels of oleate of hypothalamic fatty acid-sensing systems (activation), expression of neuropeptides (enhanced anorexigenic potential) and food intake (decrease) were counteracted by the simultaneous treatment with ghrelin. These changes provide evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus.

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“…However, the expression of ghrelin mRNA was also identified in various organs of non-mammalian vertebrates other than the stomach, and there appears to be a speciesspecific difference in ghrelin expression (Kaiya et al, 2008). In the liver, ghrelin mRNA is expressed in the hammerhead shark, goldfish, catfish and grass carp, but not in eel, rainbow trout, tilapia, bullfrog, turtle, or chicken (Kaiya et al, 2008;Feng et al, 2013). However, Ma et al (2015) demonstrated that ghrelin mRNA was located primarily in the proventriculus, followed by the liver and other tissues in E18 chicken embryos.…”

Section: Introductionmentioning

confidence: 99%

Distribution and Morphology of Ghrelin-Immunopositive Cells in the Liver of the African Ostrich

Wang

Zhang

et al. 2017

Int. J. Morphol.

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JIA-XIANG, W.; PENG, L.; XIAO-TING, Z. & LI-XUN, Y.Distribution and morphology of ghrelin-immunopositive cells in the liver of the african ostrich. Int. J. Morphol., 35(4):1285Morphol., 35(4): -1290Morphol., 35(4): , 2017. SUMMARY:Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor, and has been found in the liver of multiple vertebrates. While ghrelin has been identified in the gastrointestinal tract of African ostrich chicks, little is known regarding its distribution in the liver of the African ostrich. In the present study, the distribution and morphological characteristics of ghrelin-immunopositive (ghrelin-ip) cells in the liver of the African ostrich were investigated using immunohistochemistry. Our results indicate that the liver is divided into two sections: the capsule and the parenchyma, which comprises hepatic lobules and the hepatic portal area. The hepatic lobules include the central vein, hepatocellular cord, and the hepatic sinusoid. The hepatocellular cord is composed of hepatocytes, and Macrophagocytus stellatus (Kupffer cells) as well as endothelial cells reside within the hepatic sinusoid. ghrelin-ip cells were detected among both the Macrophagocytus stellatus and endothelial cells of the hepatic sinusoid in the African ostrich liver. In contrast, no ghrelinip cells were located within the hepatocytes or the hepatic portal area. These results clearly demonstrated the presence of ghrelin-ip cells in the liver of the African ostrich. Therefore, ghrelin may have a physiological function in the liver of the African ostrich.

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Ghrelin: A multifunctional hormone in non-mammalian vertebrates

Cited by 214 publications

References 150 publications

Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus

Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus

Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout

Distribution and Morphology of Ghrelin-Immunopositive Cells in the Liver of the African Ostrich

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