Getting serious with retinopathy: Approaching an integrated hypothesis for central serous chorioretinopathy

Bujarborua, Dhiren; Borooah, Shyamanga; Dhillon, Baljean

doi:10.1016/j.mehy.2013.04.032

Cited by 14 publications

(10 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another finding of our study, although well-established, is that men are more affected than women by CSCR. A possible explanation pertains to the epidemiology of CSCR per se, which has been found to be more frequent in middle-aged men (2, 64, 65). Nevertheless, in the examined period, financial crisis may have played a role in the increased prevalence of CSCR among men.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Financial Crisis on Central Serous Chorioretinopathy in Greece: Is There Any Correlation?

Rouvas

Chatziralli

Ladas

et al. 2013

European Journal of Ophthalmology

View full text Add to dashboard Cite

Our study suggests a potential impact of financial crisis on CSCR. Our results demonstrated that CSCR incidence, in both new and recurrent cases, has increased during the years of economic crisis in Greece, especially in 2010-2011, implying that CSCR is likely to be associated with stress or other emotional stimuli caused by financial crisis. It is also important to note that the results were similar in public and private units.

show abstract

Section: Discussionmentioning

confidence: 99%

The Impact of Financial Crisis on Central Serous Chorioretinopathy in Greece: Is There Any Correlation?

Rouvas

Chatziralli

Ladas

et al. 2013

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…However, it is still not entirely clear how corticosteroids, despite having anti-inflammatory properties, can worsen, rather than improve, the course of a disease characterized by inflammation. Researchers suggested the possibility of tissue-specific or conditional mutation of steroid hormone receptors in the choroid [34]. It is hypothesized that the pathogenesis of CSC extends beyond a tissue-specific disorder, as its comorbidity with psychological stress, hypertension and coronary diseases may suggest the involvement of systemic vascular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…As mentioned above, an association between anxiety and choroidal thickening was found also in children and adolescents. Nonetheless, within this age group, the relationship between psychiatric and ophthalmological factors does not extend to CSC, as reports of childhood CSC cases are very rare [34]. Anxiety, together with the coping strategies to deal with it, mainly involve serotoninergic and dopaminergic neural circuits starting from the prefrontal cortex, which reaches full maturation at approximately 25 years of age [42].…”

Section: Discussionmentioning

confidence: 99%

Sharing the Same Perspective. Mental Disorders and Central Serous Chorioretinopathy: A Systematic Review of Evidence from 2010 to 2020

et al. 2021

View full text Add to dashboard Cite

Background: The relevance of the association between mental disorders and other conditions might have been underestimated due to its complexity. Central Serous Chorioretinopathy (CSC) is an ophthalmological disorder associated with many psychiatric factors. The aim of this systematic review is to evaluate the association between mental disorders and CSC. Methods: Articles about studies performed on humans on CSC published in peer-reviewed journals from 1 January 2010 to 31 December 2020 were included in the review. Results: We selected 21 research papers. Nine studies measured stress and anxious depressive symptoms, which are associated with CSC onset and recurrences, emerging as a state marker of the disease. Four out of the five studies focused on sleep disorders suggested a reliable association with CSC. Four studies evaluated other various psychiatric factors. The role of psychopharmacological medication has still not been elucidated (three studies). Conclusion: Multiple pieces of evidence highlights that CSC might arise in the context of systemic disease. This notion, together with the increasing evidence supporting a link between psychiatric disorders and choroidal thickness, suggests that CSC and mental disorders may share some etiopathogenetic pathways. Further research is needed to better investigate possible common etiopathogenetic pathways, especially vascular, immunological and endocrinological systems.

show abstract

“…Classical association with stress, steroids, and activation of hypothalamus–pituitary–adrenal axis aside, recent insights suggest that psychobiological influences from the prefrontal cortex govern the terminal events at the levels of choriocapillary endothelium, retinal pigment epithelium/Bruch's membrane interface leading to CSCR via dopamine, and serotonin pathways. [37] Angiographic evidences suggest that CSCR arises when increased hydrostatic pressure in the choroid associated with choroidal hyperpermeability reverses the normal physiologic flow of fluid from the retina to the choroid.…”

Section: Discussionmentioning

confidence: 99%

Quetiapine associated Central Serous Chorioretinopathy: Implicit role of serotonin and dopamine pathways

Jain

2019

Indian J Ophthalmol

View full text Add to dashboard Cite

A 30-year-old insomniac, an off-label user of quetiapine, presented with blurring of central vision, eventually diagnosed as central serous chorioretinopathy. A potential association was suspected based on the drug's actions on the autonomic nervous system. He showed improvement on drug withdrawal; then he unwittingly resumed quetiapine and had a recurrence. Possible underlying mechanisms that include alteration in choroidal perfusion through serotonin and dopamine receptors are discussed. Although retinal vein occlusions and pigment epithelial detachment have been described with quetiapine, to the author's knowledge, this is the first case report of quetiapine-associated central serous chorioretinopathy.

show abstract

Getting serious with retinopathy: Approaching an integrated hypothesis for central serous chorioretinopathy

Cited by 14 publications

References 49 publications

The Impact of Financial Crisis on Central Serous Chorioretinopathy in Greece: Is There Any Correlation?

The Impact of Financial Crisis on Central Serous Chorioretinopathy in Greece: Is There Any Correlation?

Sharing the Same Perspective. Mental Disorders and Central Serous Chorioretinopathy: A Systematic Review of Evidence from 2010 to 2020

Quetiapine associated Central Serous Chorioretinopathy: Implicit role of serotonin and dopamine pathways

Contact Info

Product

Resources

About